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Evamist Spray Btl — prescription drug image

Evamist

Evamist 8.1ML of 1.53MG/SPRAY

Prescriptions & Refills
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What is Evamist?

Evamist is a topical medication that contains estradiol, a form of estrogen. It is used to help relieve symptoms of menopause, such as hot flashes and vaginal dryness.

Prescription savings · · · ·

What is Evamist ?

Evamist is a topical medication that contains estradiol, a form of estrogen. It is used to help relieve symptoms of menopause, such as hot flashes and vaginal dryness.

Source: MedlinePlus, U.S. National Library of Medicine

  • Sudden and severe stomach pain, with or without nausea, vomiting, fever, and lightheadedness
  • Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking
  • Loss of vision, double vision, or other vision changes
  • Chest pain, trouble breathing, or coughing up blood
  • Breast lumps
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Swelling in your hands, ankles, or feet
  • Unusual vaginal bleeding or heavy bleeding
  • Unusual vaginal bleeding or heavy bleeding
  • Do not allow children or pets to touch the skin where you applied the medicine. If this happens, wash the child or pet's skin with soap and water.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments. You should have regular exams and mammograms as directed by your doctor.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results. You may need to stop using this medicine before you have surgery or if you need to stay in bed for a long time.
  • Pregnancy after menopause is not likely, but if you think you could be pregnant, tell your doctor. This medicine could harm an unborn baby.
  • Tell your doctor if you are breastfeeding, or if you have kidney disease, asthma, diabetes, edema (body swelling), endometriosis, epilepsy, migraine headaches, porphyria, lupus, thyroid problems, heart disease, high blood pressure, high cholesterol or triglycerides, inherited angioedema, or a history of cancer. Tell your doctor if you had liver problems caused by pregnancy or estrogen.
  • This medicine may cause the following problems:Higher risk of heart attack, stroke, or blood clotsHigher risk of endometrial cancer, breast cancer, or uterine cancerGallbladder diseaseHigher risk of dementia
What is Evamist used for?
Evamist is FDA-approved to treat moderate-to-severe hot flashes and night sweats (vasomotor symptoms) caused by menopause. It is applied as a metered spray to the inner forearm. It is not approved for preventing heart disease or dementia.
Is there a generic version of Evamist?
No. As of now there is no FDA-approved generic equivalent of Evamist's transdermal spray. If cost is a concern, ask your provider about other FDA-approved estrogen products, and compare pharmacy prices for Evamist itself using a coupon.
How do you apply Evamist spray correctly?
Evamist is sprayed onto a clean area of the inner forearm according to your prescriber's directions, then allowed to dry fully before covering the area or letting it be touched. Because the spray is flammable until dry, avoid open flame near the application site. Always follow the specific instructions your provider and pharmacist give you, including how to avoid transferring the medication to children or other people through skin contact.
What are the side effects and risks of Evamist?
Evamist carries an FDA boxed warning for endometrial cancer risk (when used without a progestogen in women with a uterus), increased risk of stroke and blood clots, probable increased dementia risk in women 65 and older, increased invasive breast cancer risk with combined estrogen-progestin therapy, and reports of unintentional secondary exposure to children who touch the application site. It should not be used by people with undiagnosed vaginal bleeding, current or past breast cancer, a history of blood clots, or liver impairment. Talk with your provider about your personal risk factors.
How much does Evamist cost with insurance or a coupon?
Cost varies by pharmacy, insurance plan, and whether you use a manufacturer savings card or a cash coupon. The manufacturer's savings program is generally limited to people with commercial insurance and terms can change, while a cash coupon can be used regardless of insurance status, including by uninsured and Medicare patients. Enter your ZIP above to see today's price near you.
How much does Evamist cost without insurance?
The price of Evamist without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Evamist?
Common side effects of Evamist may include: Sudden and severe stomach pain, with or without nausea, vomiting, fever, and lightheadedness, Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking, Loss of vision, double vision, or other vision changes, Chest pain, trouble breathing, or coughing up blood, Breast lumps. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Evamist?
Generic versions may be available for Evamist. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Evamist on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Evamist?
The cheapest pharmacy for Evamist depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Evamist near you.

Evamist Coupons & Prices

Evamist 8.1ML of 1.53MG/SPRAY

Prescriptions & Refills
Licensed US providers · Online visit in minutes
Evamist Spray Btl — prescription drug image
Prescription
Evamist 8.1ml of 1.53mg/spray (1)
your area ·
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Weight-loss medication, prescribed online

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$146/mo vs. brand-name GLP-1 medications $1,300+/mo Save up to 88%
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Compounded GLP-1 medications are not FDA-approved and are prepared by state-licensed compounding pharmacies. They are not affiliated with, endorsed by, or equivalent to any brand-name medication or manufacturer. Prescription required; eligibility is determined by a licensed provider. Prices are estimates and may vary.

Evamist is a brand-name transdermal estradiol spray with no available generic, so most people searching for an Evamist coupon are comparing the manufacturer's savings program against a cash discount that also works without commercial insurance; enter your ZIP above to see today's price at pharmacies near you before you decide which route saves more.

What Is Evamist and How Does It Work?

Evamist (estradiol transdermal spray) is FDA-approved to treat moderate-to-severe hot flashes and night sweats caused by menopause. Instead of a patch or pill, it delivers a metered dose of estrogen as a quick-drying spray applied to the inner forearm, where the hormone absorbs through the skin. Evamist is not approved or indicated for preventing cardiovascular disease or dementia.

Because the product is a flammable, alcohol-based spray, it's important to let the application site dry fully before going near an open flame, and to follow the label's instructions on covering the spray site to avoid transferring the medication to others through skin contact.

Manufacturer Savings Card vs. the Rx.com Cash Coupon

Evamist has an official manufacturer savings program; details are listed on the manufacturer's own site (evamist.com), and terms and eligibility can change, so it's worth checking there directly. Like most brand manufacturer cards, it's generally limited to patients with commercial insurance and typically excludes people on Medicare, Medicaid, or without insurance.

The Rx.com cash coupon works differently: it isn't tied to your insurance status, so it can help if you're uninsured, on Medicare, or if your manufacturer card is declined or unavailable at your pharmacy. Because Evamist has no generic version, pharmacy pricing can vary, so it's worth comparing your options before you fill.

Generic Availability and Alternatives

There is currently no FDA-approved generic version of Evamist's spray formulation, so brand pricing (with a coupon or the manufacturer's savings program) is the main lever for savings on this exact product. If cost is a concern, it's reasonable to ask your provider whether a different estrogen delivery form might suit you, since other FDA-approved estradiol and estrogen products treat similar menopausal symptoms.

Options some patients discuss with their provider include estradiol tablets, the Premarin family of estrogen products, and other transdermal estrogen patches such as Climara, Vivelle-Dot, and Estrace. These are different products with their own dosing, risks, and FDA labeling — this is not a recommendation to switch, only a starting point for a conversation with your prescriber.

Evamist Safety Information

Evamist carries an FDA boxed warning covering several risks: endometrial cancer risk when estrogen is used without a progestogen in women who still have a uterus; increased risk of stroke and blood clots (DVT) with estrogen alone, and increased risk of blood clots, stroke, and heart attack when estrogen is combined with a progestin; probable increased dementia risk in women 65 and older; increased risk of invasive breast cancer with combined estrogen-progestin use; and reports of unintentional secondary exposure — including breast budding, breast masses, and gynecomastia — in children who came into accidental skin contact with a treated adult's application site.

Evamist should not be used by anyone with undiagnosed abnormal vaginal bleeding, current or past breast cancer, a current or past history of blood clots or arterial blood clot disease, or known liver impairment. Your provider should also monitor for gallbladder disease, vision changes, and elevated triglycerides. This is general information, not medical advice — talk with your provider about whether Evamist is appropriate for you.

Sources & accuracy

This Evamist information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Evamist on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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