Gonal-F
Gonal-f 450UNIT
What is Gonal-F?
Gonal-f is an injectable medication used in the treatment of infertility. Follitropin Alfa is the generic version of Gonal-f. The average price for Gonal-f is approximately $1,223 for a 450 intl unit injection. Using Rx.com’s coupon card can earn you significant savings on your Gonal-f prescription at participating pharmacies near you.Side Effects
- Yellowing of your skin or the whites of your eyes.
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Chest pain, trouble breathing, coughing up blood
Warnings
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant before starting treatment.
- Tell your doctor if you are breastfeeding, or if you have liver disease, heart disease, or a history of breathing problems (including asthma), blood clots, stroke, ovary problems, or stomach surgery.
- This medicine may cause the following problems:Ovary problems (including ovarian hyperstimulation syndrome, twisting or enlargement of the ovaries, ovarian cancer)Lung or breathing problemsBlood clotsIncreased risk of ectopic pregnancy or miscarriage
- Talk to your doctor about the possibility that this medicine could cause you to get pregnant with twins, triplets, or multiple babies.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. Semen testing and ultrasound examinations will also be needed to check for unwanted effects.
Prescription savings · · · ·
What is Gonal-F ?
Gonal-f is an injectable medication used in the treatment of infertility. Follitropin Alfa is the generic version of Gonal-f. The average price for Gonal-f is approximately $1,223 for a 450 intl unit injection. Using Rx.com’s coupon card can earn you significant savings on your Gonal-f prescription at participating pharmacies near you.- Yellowing of your skin or the whites of your eyes.
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Chest pain, trouble breathing, coughing up blood
- Diarrhea, nausea, vomiting, stomach pain
- Numbness or weakness in your arm, leg, or on one side of your body, pain in your lower leg (calf)
- Severe menstrual-like cramps, bloating, passing gas, vaginal bleeding, weight gain
- Sudden or severe headache, problems with vision, speech, or walking
- Painful or difficult breathing.
- Pain in your lower leg (calf).
- Rapid weight gain.
- Pain or swelling in your lower abdomen.
- Vomiting, stomach pain, or diarrhea.
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant before starting treatment.
- Tell your doctor if you are breastfeeding, or if you have liver disease, heart disease, or a history of breathing problems (including asthma), blood clots, stroke, ovary problems, or stomach surgery.
- This medicine may cause the following problems:Ovary problems (including ovarian hyperstimulation syndrome, twisting or enlargement of the ovaries, ovarian cancer)Lung or breathing problemsBlood clotsIncreased risk of ectopic pregnancy or miscarriage
- Talk to your doctor about the possibility that this medicine could cause you to get pregnant with twins, triplets, or multiple babies.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. Semen testing and ultrasound examinations will also be needed to check for unwanted effects.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Pain in your lower leg (calf).
- Pain or swelling in your lower abdomen.
- Painful or difficult breathing.
- Rapid weight gain.
- Vomiting, stomach pain, or diarrhea.
- Yellowing of your skin or the whites of your eyes.
Gonal-F Coupons & Prices
Gonal-f 450UNIT
Weight-loss medication, prescribed online
Licensed U.S. providers · No insurance needed · Shipped to your door
Gonal-f (follitropin alfa) is a brand-name injectable fertility medicine from EMD Serono, and because there is no substitutable generic version of it in the United States, the price you pay can vary a lot from pharmacy to pharmacy. A Gonal-f coupon from Rx.com is a free cash-price discount you can use at participating pharmacies whether or not you have insurance, which matters because many health plans cover fertility drugs poorly or not at all. Gonal-f comes in more than one presentation, and they are not interchangeable: the multiple-dose vial of powder that is mixed before use, the Gonal-f RFF 75 IU single-dose vial, and the Gonal-f RFF Redi-ject prefilled pen. Enter your ZIP code above to see today's Gonal-f price near you for the exact presentation your clinic prescribed, and print or text yourself the coupon before you fill.
What Gonal-f is and how it works
Gonal-f is a recombinant human follicle-stimulating hormone (FSH), also sold as Gonal-f RFF and the Gonal-f RFF Redi-ject prefilled pen. FSH is the hormone that tells the ovaries to grow follicles (the fluid-filled sacs that contain eggs). Because it is made in the lab rather than collected from urine, Gonal-f is a "recombinant" gonadotropin. It is given as a subcutaneous (under-the-skin) injection, usually once a day, for a limited number of days in a monitored treatment cycle.
The FDA-approved uses on the label are:
- Ovulation induction in women who do not ovulate regularly, when the cause of infertility is functional and is not primary ovarian failure.
- Development of multiple follicles in ovulatory women as part of an Assisted Reproductive Technology (ART) cycle such as IVF.
- Induction of sperm production in men with primary or secondary hypogonadotropic hypogonadism, when the cause of infertility is not primary testicular failure. In men it is used together with hCG, after pretreatment with hCG. Note that this male indication appears on the label for the Gonal-f multiple-dose vial; the Gonal-f RFF presentations (the 75 IU single-dose vial and the RFF Redi-ject pen) are approved for the two uses in women.
Gonal-f is essentially never used alone. It is part of a protocol that is watched closely with ultrasound and blood estradiol levels, and it is typically paired with other medicines such as an hCG trigger shot and a GnRH antagonist. The label states plainly that it should be used only by clinicians experienced in infertility treatment.
Gonal-f coupon: manufacturer savings card vs. Rx.com cash coupon
Two very different kinds of savings show up when you search for a Gonal-f coupon, and it helps to know which one you actually qualify for.
- The manufacturer savings card. EMD Serono, the company that makes Gonal-f, runs official fertility medication savings programs, described on its own patient website (emdseronofertility.com). Manufacturer savings cards like these are generally limited to people with commercial (private) insurance and are typically not allowed for people with Medicare, Medicaid, TRICARE, or other government coverage. Eligibility rules, enrollment steps, and benefit terms vary and change, so check the manufacturer's official site or ask your fertility clinic's financial counselor rather than trusting a third-party page. EMD Serono has also historically offered patient assistance and compassionate-care style programs for people who qualify financially, so ask the clinic about those too.
- The Rx.com cash coupon. Our coupon is not insurance and does not depend on having insurance. It sets a discounted cash price at participating pharmacies. That makes it useful in exactly the situations where a manufacturer card falls short: you are uninsured, you are on Medicare or another government plan, your insurance excludes fertility drugs entirely, or the savings card was declined at the counter.
You cannot combine a manufacturer card, insurance, and a discount coupon on the same fill, so the practical move is to price it both ways. Because there is no FDA-approved, substitutable generic follitropin alfa marketed in the U.S., there is no generic substitute to fall back on, which makes shopping the price worthwhile. Prices vary by pharmacy and by presentation, so it is worth comparing. Fertility medicines are often dispensed through specialty pharmacies, so before you commit, enter your ZIP above to see today's Gonal-f price and confirm the pharmacy stocks the exact presentation your clinic prescribed: the multiple-dose vial, the Gonal-f RFF 75 IU single-dose vial, or the Gonal-f RFF Redi-ject pen. Ask your clinic whether they have a preferred fertility pharmacy as well, and compare that against the coupon price.
Gonal-f vs. Follistim and other fertility medications
Gonal-f is one of several injectable gonadotropins, and in a typical cycle it is used alongside other drugs rather than instead of them. Common medicines you may see on the same protocol:
- Follistim AQ (follitropin beta) is the closest comparison. It is also a recombinant FSH, but a slightly different version of the hormone, made by a different company, and delivered with a different injection pen and dosing device. Clinics often pick one over the other based on protocol preference, pen handling, or pharmacy availability rather than a large difference in what the drug does.
- Menopur (menotropins) supplies both FSH and LH activity and is sometimes added to an FSH like Gonal-f.
- Ovidrel (choriogonadotropin alfa) is an hCG "trigger" that finishes egg maturation once the follicles are ready.
- Cetrotide (cetrorelix) and ganirelix are GnRH antagonists used to prevent the body from releasing an egg too early during stimulation.
- Clomiphene citrate (Clomid) is an oral medicine that is FDA-approved for ovulation induction and is often tried earlier in the treatment ladder for some people who do not ovulate; it is a pill, not an injection.
Which of these is right for you depends on your diagnosis, your ovarian reserve, and the protocol your clinic uses. This page is for price comparison, not for choosing a protocol; that decision belongs to your fertility specialist.
Gonal-f side effects and safety
Gonal-f does not carry an FDA boxed warning. The most important risk on its label is Ovarian Hyperstimulation Syndrome (OHSS), which can become severe and even life-threatening. Call your clinic right away if you develop severe pelvic or abdominal pain, nausea or vomiting, rapid weight gain, or abdominal swelling. Your care team monitors for this with ultrasound and estradiol levels, and will withhold the hCG trigger if your ovaries are abnormally enlarged at the end of stimulation. Other risks the label lists include blood clots and related events (stroke, pulmonary embolism, arterial blockage), serious lung problems, ovarian torsion (a twisted ovary), ovarian enlargement and cysts, ectopic pregnancy, pregnancy loss, and congenital malformations. Multiple births are common with gonadotropins: according to the label, multiple births occurred in 20% of live births in women treated for ovulation induction and 35.1% of live births in women undergoing ART.
More common, milder side effects include injection-site reactions, headache, abdominal or pelvic pain, nausea, and ovarian cysts. In men, acne, breast enlargement (gynecomastia), and injection-site reactions are reported. Per the label, Gonal-f is contraindicated in women and men who have had a hypersensitivity reaction to recombinant FSH products or their ingredients, who have high FSH levels indicating primary gonadal failure, who have uncontrolled non-gonadal endocrine problems (such as thyroid or adrenal disorders), who have sex-hormone-dependent tumors of the reproductive tract and accessory organs, or who have tumors of the pituitary gland or hypothalamus. In women it is also contraindicated with abnormal uterine bleeding of undetermined origin and with an ovarian cyst or ovarian enlargement of undetermined origin. This page is a price and information resource, not medical advice: talk with your fertility specialist or pharmacist about whether Gonal-f is appropriate for you and how to use it safely.
This Gonal-F information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Gonal-F on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.