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Gonal-F

Gonal-f 450UNIT

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What is Gonal-F?

Gonal-f is an injectable medication used in the treatment of infertility. Follitropin Alfa is the generic version of Gonal-f. The average price for Gonal-f is approximately $1,223 for a 450 intl unit injection. Using Rx.com’s coupon card can earn you significant savings on your Gonal-f prescription at participating pharmacies near you.

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What is Gonal-F ?

Gonal-f is an injectable medication used in the treatment of infertility. Follitropin Alfa is the generic version of Gonal-f. The average price for Gonal-f is approximately $1,223 for a 450 intl unit injection. Using Rx.com’s coupon card can earn you significant savings on your Gonal-f prescription at participating pharmacies near you.
  • Yellowing of your skin or the whites of your eyes.
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest pain, trouble breathing, coughing up blood
  • Diarrhea, nausea, vomiting, stomach pain
  • Numbness or weakness in your arm, leg, or on one side of your body, pain in your lower leg (calf)
  • Severe menstrual-like cramps, bloating, passing gas, vaginal bleeding, weight gain
  • Sudden or severe headache, problems with vision, speech, or walking
  • Painful or difficult breathing.
  • Pain in your lower leg (calf).
  • Rapid weight gain.
  • Pain or swelling in your lower abdomen.
  • Vomiting, stomach pain, or diarrhea.
  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant before starting treatment.
  • Tell your doctor if you are breastfeeding, or if you have liver disease, heart disease, or a history of breathing problems (including asthma), blood clots, stroke, ovary problems, or stomach surgery.
  • This medicine may cause the following problems:Ovary problems (including ovarian hyperstimulation syndrome, twisting or enlargement of the ovaries, ovarian cancer)Lung or breathing problemsBlood clotsIncreased risk of ectopic pregnancy or miscarriage
  • Talk to your doctor about the possibility that this medicine could cause you to get pregnant with twins, triplets, or multiple babies.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. Semen testing and ultrasound examinations will also be needed to check for unwanted effects.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Pain in your lower leg (calf).
  • Pain or swelling in your lower abdomen.
  • Painful or difficult breathing.
  • Rapid weight gain.
  • Vomiting, stomach pain, or diarrhea.
  • Yellowing of your skin or the whites of your eyes.
How much does Gonal-f cost without insurance?
There is no single cash price for Gonal-f. What you pay depends on the strength, which presentation you were prescribed (the multiple-dose vial, the Gonal-f RFF 75 IU single-dose vial, or the Gonal-f RFF Redi-ject prefilled pen), how many days of stimulation your protocol calls for, and which pharmacy fills it. Prices vary from pharmacy to pharmacy, and there is no substitutable generic follitropin alfa in the U.S. to fall back on, so it pays to compare. Enter your ZIP code above to see today's Gonal-f price near you with a free Rx.com cash coupon, and also ask your clinic which fertility or specialty pharmacies they work with so you can compare.
Is there a generic version of Gonal-f?
No. As of now there is no FDA-approved, substitutable generic version of Gonal-f (follitropin alfa) marketed in the United States. Follistim AQ (follitropin beta) is a different recombinant FSH product from a different manufacturer, not a generic of Gonal-f, and pharmacies cannot swap one for the other on their own. Because there is no generic to fall back on, comparing cash prices and asking about the manufacturer's savings and assistance programs are the main ways to reduce what you pay.
What are the most common side effects of Gonal-f?
The most commonly reported side effects are injection-site reactions (redness, pain, or bruising where the shot is given), headache, abdominal or pelvic pain, nausea, and ovarian cysts. In men treated for hypogonadotropic hypogonadism, acne, breast enlargement, and injection-site reactions are reported. The serious risk to know about is ovarian hyperstimulation syndrome (OHSS): contact your clinic promptly if you have severe abdominal or pelvic pain, vomiting, rapid weight gain, or abdominal swelling.
How long do you take Gonal-f during an IVF or IUI cycle?
Gonal-f is given as a daily subcutaneous injection for a limited stretch of the treatment cycle, commonly around one to two weeks, but the exact number of days is individualized. Your clinic adjusts the dose and decides when to stop based on ultrasound follicle measurements and blood estradiol levels, and then usually gives an hCG trigger such as Ovidrel once the follicles are mature. Follow your clinic's written protocol exactly rather than a general timeline, and never adjust your own dose.
What is the difference between Gonal-f and Follistim?
Both are recombinant follicle-stimulating hormone products used to stimulate the ovaries, but they are not the same molecule or the same product. Gonal-f is follitropin alfa, made by EMD Serono; Follistim AQ is follitropin beta, made by a different company. They also use different injection pens and dosing devices, so the way you measure and give the dose differs. Neither is a generic of the other, and they are not interchangeable at the pharmacy. Clinics generally choose based on protocol preference, pen handling, and availability.
What are the different forms of Gonal-f, and does my pharmacy have to give me the exact one my clinic prescribed?
There are three U.S. presentations, each with its own labeling: the Gonal-f multiple-dose vial (a powder supplied in 450 IU and 1,050 IU vials that is mixed with the supplied diluent before use), the Gonal-f RFF 75 IU single-dose vial (a powder that is mixed and then used right away), and the Gonal-f RFF Redi-ject prefilled pen (a ready-to-use liquid pen). They are dosed and handled differently and are not swapped for one another at the counter, so when you price-shop, confirm the pharmacy stocks the exact presentation on your prescription.
Does Gonal-f need to be refrigerated?
Not necessarily, and refrigeration is not required once you have started using it. Storage rules differ by presentation, so follow the package insert your pharmacy gives you. Per the FDA labeling: the multiple-dose vials of powder may be stored either refrigerated or at room temperature (2 to 25 degrees C / 36 to 77 degrees F), protected from light, and after the vial is mixed, the solution may also be kept either refrigerated or at room temperature and any unused solution is discarded after 28 days. The Gonal-f RFF 75 IU single-dose vial may likewise be stored refrigerated or at room temperature and protected from light, but once it is mixed it is used immediately and any leftover is discarded. The Gonal-f RFF Redi-ject prefilled pen may be kept at room temperature (20 to 25 degrees C / 68 to 77 degrees F) for up to three months after it is dispensed, or until the expiration date, whichever comes first; after the first injection it may be stored either refrigerated (2 to 8 degrees C) or at room temperature for up to 28 days. Never freeze it, and ask your fertility pharmacist about storage, mixing, and how to travel with it.
How much does Gonal-F cost without insurance?
The price of Gonal-F without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 26% off retail prices with a free Rx.com coupon.
What are the common side effects of Gonal-F?
Common side effects of Gonal-F may include: Yellowing of your skin or the whites of your eyes., Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Chest pain, trouble breathing, coughing up blood, Diarrhea, nausea, vomiting, stomach pain, Numbness or weakness in your arm, leg, or on one side of your body, pain in your lower leg (calf). This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Gonal-F?
Generic versions may be available for Gonal-F. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Gonal-F on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Gonal-F?
The cheapest pharmacy for Gonal-F depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Gonal-F near you.

Gonal-F Coupons & Prices

Gonal-f 450UNIT

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Gonal-F Solution Reconstituted — prescription drug image
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Gonal-F 450unit (1)
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Compounded GLP-1 medications are not FDA-approved and are prepared by state-licensed compounding pharmacies. They are not affiliated with, endorsed by, or equivalent to any brand-name medication or manufacturer. Prescription required; eligibility is determined by a licensed provider. Prices are estimates and may vary.

Gonal-f (follitropin alfa) is a brand-name injectable fertility medicine from EMD Serono, and because there is no substitutable generic version of it in the United States, the price you pay can vary a lot from pharmacy to pharmacy. A Gonal-f coupon from Rx.com is a free cash-price discount you can use at participating pharmacies whether or not you have insurance, which matters because many health plans cover fertility drugs poorly or not at all. Gonal-f comes in more than one presentation, and they are not interchangeable: the multiple-dose vial of powder that is mixed before use, the Gonal-f RFF 75 IU single-dose vial, and the Gonal-f RFF Redi-ject prefilled pen. Enter your ZIP code above to see today's Gonal-f price near you for the exact presentation your clinic prescribed, and print or text yourself the coupon before you fill.

What Gonal-f is and how it works

Gonal-f is a recombinant human follicle-stimulating hormone (FSH), also sold as Gonal-f RFF and the Gonal-f RFF Redi-ject prefilled pen. FSH is the hormone that tells the ovaries to grow follicles (the fluid-filled sacs that contain eggs). Because it is made in the lab rather than collected from urine, Gonal-f is a "recombinant" gonadotropin. It is given as a subcutaneous (under-the-skin) injection, usually once a day, for a limited number of days in a monitored treatment cycle.

The FDA-approved uses on the label are:

  • Ovulation induction in women who do not ovulate regularly, when the cause of infertility is functional and is not primary ovarian failure.
  • Development of multiple follicles in ovulatory women as part of an Assisted Reproductive Technology (ART) cycle such as IVF.
  • Induction of sperm production in men with primary or secondary hypogonadotropic hypogonadism, when the cause of infertility is not primary testicular failure. In men it is used together with hCG, after pretreatment with hCG. Note that this male indication appears on the label for the Gonal-f multiple-dose vial; the Gonal-f RFF presentations (the 75 IU single-dose vial and the RFF Redi-ject pen) are approved for the two uses in women.

Gonal-f is essentially never used alone. It is part of a protocol that is watched closely with ultrasound and blood estradiol levels, and it is typically paired with other medicines such as an hCG trigger shot and a GnRH antagonist. The label states plainly that it should be used only by clinicians experienced in infertility treatment.

Gonal-f coupon: manufacturer savings card vs. Rx.com cash coupon

Two very different kinds of savings show up when you search for a Gonal-f coupon, and it helps to know which one you actually qualify for.

  • The manufacturer savings card. EMD Serono, the company that makes Gonal-f, runs official fertility medication savings programs, described on its own patient website (emdseronofertility.com). Manufacturer savings cards like these are generally limited to people with commercial (private) insurance and are typically not allowed for people with Medicare, Medicaid, TRICARE, or other government coverage. Eligibility rules, enrollment steps, and benefit terms vary and change, so check the manufacturer's official site or ask your fertility clinic's financial counselor rather than trusting a third-party page. EMD Serono has also historically offered patient assistance and compassionate-care style programs for people who qualify financially, so ask the clinic about those too.
  • The Rx.com cash coupon. Our coupon is not insurance and does not depend on having insurance. It sets a discounted cash price at participating pharmacies. That makes it useful in exactly the situations where a manufacturer card falls short: you are uninsured, you are on Medicare or another government plan, your insurance excludes fertility drugs entirely, or the savings card was declined at the counter.

You cannot combine a manufacturer card, insurance, and a discount coupon on the same fill, so the practical move is to price it both ways. Because there is no FDA-approved, substitutable generic follitropin alfa marketed in the U.S., there is no generic substitute to fall back on, which makes shopping the price worthwhile. Prices vary by pharmacy and by presentation, so it is worth comparing. Fertility medicines are often dispensed through specialty pharmacies, so before you commit, enter your ZIP above to see today's Gonal-f price and confirm the pharmacy stocks the exact presentation your clinic prescribed: the multiple-dose vial, the Gonal-f RFF 75 IU single-dose vial, or the Gonal-f RFF Redi-ject pen. Ask your clinic whether they have a preferred fertility pharmacy as well, and compare that against the coupon price.

Gonal-f vs. Follistim and other fertility medications

Gonal-f is one of several injectable gonadotropins, and in a typical cycle it is used alongside other drugs rather than instead of them. Common medicines you may see on the same protocol:

  • Follistim AQ (follitropin beta) is the closest comparison. It is also a recombinant FSH, but a slightly different version of the hormone, made by a different company, and delivered with a different injection pen and dosing device. Clinics often pick one over the other based on protocol preference, pen handling, or pharmacy availability rather than a large difference in what the drug does.
  • Menopur (menotropins) supplies both FSH and LH activity and is sometimes added to an FSH like Gonal-f.
  • Ovidrel (choriogonadotropin alfa) is an hCG "trigger" that finishes egg maturation once the follicles are ready.
  • Cetrotide (cetrorelix) and ganirelix are GnRH antagonists used to prevent the body from releasing an egg too early during stimulation.
  • Clomiphene citrate (Clomid) is an oral medicine that is FDA-approved for ovulation induction and is often tried earlier in the treatment ladder for some people who do not ovulate; it is a pill, not an injection.

Which of these is right for you depends on your diagnosis, your ovarian reserve, and the protocol your clinic uses. This page is for price comparison, not for choosing a protocol; that decision belongs to your fertility specialist.

Gonal-f side effects and safety

Gonal-f does not carry an FDA boxed warning. The most important risk on its label is Ovarian Hyperstimulation Syndrome (OHSS), which can become severe and even life-threatening. Call your clinic right away if you develop severe pelvic or abdominal pain, nausea or vomiting, rapid weight gain, or abdominal swelling. Your care team monitors for this with ultrasound and estradiol levels, and will withhold the hCG trigger if your ovaries are abnormally enlarged at the end of stimulation. Other risks the label lists include blood clots and related events (stroke, pulmonary embolism, arterial blockage), serious lung problems, ovarian torsion (a twisted ovary), ovarian enlargement and cysts, ectopic pregnancy, pregnancy loss, and congenital malformations. Multiple births are common with gonadotropins: according to the label, multiple births occurred in 20% of live births in women treated for ovulation induction and 35.1% of live births in women undergoing ART.

More common, milder side effects include injection-site reactions, headache, abdominal or pelvic pain, nausea, and ovarian cysts. In men, acne, breast enlargement (gynecomastia), and injection-site reactions are reported. Per the label, Gonal-f is contraindicated in women and men who have had a hypersensitivity reaction to recombinant FSH products or their ingredients, who have high FSH levels indicating primary gonadal failure, who have uncontrolled non-gonadal endocrine problems (such as thyroid or adrenal disorders), who have sex-hormone-dependent tumors of the reproductive tract and accessory organs, or who have tumors of the pituitary gland or hypothalamus. In women it is also contraindicated with abnormal uterine bleeding of undetermined origin and with an ovarian cyst or ovarian enlargement of undetermined origin. This page is a price and information resource, not medical advice: talk with your fertility specialist or pharmacist about whether Gonal-f is appropriate for you and how to use it safely.

Sources & accuracy

This Gonal-F information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Gonal-F on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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