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Hydroxyzine Hcl

hydrOXYzine HCl 25MG

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What is Hydroxyzine Hcl?

Hydroxyzine HCl is a prescription antihistamine with anxiolytic (anti-anxiety) and sedative properties. It is used to treat generalized anxiety disorder (GAD), anxiety and tension associated with various conditions, itching (pruritus) from allergic reactions, and as a sedative or preoperative medication. Unlike benzodiazepines, hydroxyzine is not habit-forming or controlled. Hydroxyzine works by blocking histamine H1 receptors and has additional activity in the central nervous system that produces its calming and anti-anxiety effects. For anxiety, doses typically range from 25–100 mg three to four times daily. For sleep and short-term anxiety relief, 25–100 mg at bedtime is commonly prescribed. A licensed provider can prescribe hydroxyzine through Rx.com for anxiety, sleep issues, or itching. It is a very affordable generic medication with an Rx.com coupon.

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What is Hydroxyzine Hcl ?

Hydroxyzine HCl is a prescription antihistamine with anxiolytic (anti-anxiety) and sedative properties. It is used to treat generalized anxiety disorder (GAD), anxiety and tension associated with various conditions, itching (pruritus) from allergic reactions, and as a sedative or preoperative medication. Unlike benzodiazepines, hydroxyzine is not habit-forming or controlled. Hydroxyzine works by blocking histamine H1 receptors and has additional activity in the central nervous system that produces its calming and anti-anxiety effects. For anxiety, doses typically range from 25–100 mg three to four times daily. For sleep and short-term anxiety relief, 25–100 mg at bedtime is commonly prescribed. A licensed provider can prescribe hydroxyzine through Rx.com for anxiety, sleep issues, or itching. It is a very affordable generic medication with an Rx.com coupon.
  • Severe drowsiness, clumsiness, or confusion
  • Faintness
  • Fast heartbeat
  • Shortness of breath or trouble breathing
  • Nervousness
  • Changes in vision, such as trouble focusing
  • This medicine may cause drowsiness. If it does, avoid driving a car or using machinery.
  • This medicine may cause a skin rash when you are out in the sun. Use a sunscreen when you are outside, and try not to spend long periods in direct sunlight.
  • Ask your doctor before taking this medicine if you are pregnant or breastfeeding, or if you have glaucoma or trouble urinating.
  • This medicine might contain phenylalanine. This is only a concern if you have a disorder called phenylketonuria (a problem with amino acids). Talk to your doctor before using this medicine.
  • Side effects of this medicine may occur more frequently in young children and older adults.
  • Some antihistamine syrups contain alcohol.
What is hydroxyzine HCl used for?
Hydroxyzine HCl is FDA-approved to relieve anxiety and tension, to ease itching from allergic skin conditions such as chronic hives, atopic dermatitis, and contact dermatoses, and as a sedative before and after surgery to help control nausea and vomiting and reduce the need for narcotic pain medicine. Doctors also commonly prescribe it off-label for short-term sleep problems and for generalized anxiety because it is non-habit-forming.
Is hydroxyzine a controlled substance or addictive?
No. Hydroxyzine is not a controlled substance and is not considered habit-forming, which is one reason it is sometimes used as an alternative to benzodiazepines for anxiety. It can still cause strong drowsiness and other side effects, so it should only be taken as prescribed.
What is the difference between hydroxyzine HCl and hydroxyzine pamoate (Vistaril)?
They are two salt forms of the same active drug. Hydroxyzine hydrochloride (HCl) was sold as the now-discontinued brand Atarax and remains available as a generic. Hydroxyzine pamoate is sold under the brand Vistaril. Both are used for very similar purposes, such as anxiety and itching. Your prescriber may choose one salt form over the other.
How long does hydroxyzine take to work for anxiety?
Hydroxyzine generally takes effect fairly quickly, often within about 30 minutes to an hour, which is why it is sometimes used for short-term or as-needed anxiety. Exact timing varies by person and dose. Follow your prescriber's directions and ask your pharmacist or provider if you have questions about how and when to take it.
Can you take hydroxyzine every day for anxiety or sleep?
Hydroxyzine is FDA-approved for anxiety and is used off-label for sleep, and some people take it regularly under a doctor's direction. Because it can cause significant drowsiness, anticholinergic effects, and rarely heart-rhythm concerns, whether daily use is appropriate depends on your health, other medicines, and age. This is not medical advice; talk with your provider about the right dose and schedule for you.
How much does Hydroxyzine Hcl cost without insurance?
The price of Hydroxyzine Hcl without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Hydroxyzine Hcl?
Common side effects of Hydroxyzine Hcl may include: Severe drowsiness, clumsiness, or confusion, Faintness, Fast heartbeat, Shortness of breath or trouble breathing, Nervousness. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Hydroxyzine Hcl?
Generic versions may be available for Hydroxyzine Hcl. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Hydroxyzine Hcl on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Hydroxyzine Hcl?
The cheapest pharmacy for Hydroxyzine Hcl depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Hydroxyzine Hcl near you.

Hydroxyzine Hcl Coupons & Prices

hydrOXYzine HCl 25MG

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Hydroxyzine Hcl Tablet — prescription drug image
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Hydroxyzine Hcl 25mg (30)
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Looking for a hydroxyzine HCl coupon? Hydroxyzine hydrochloride is an FDA-approved, non-controlled generic antihistamine used to relieve anxiety and tension, ease itching from allergic skin conditions, and provide sedation. Because it is already a low-cost generic, you don't need a printed coupon or a membership to pay less. The cash price still varies widely from one pharmacy to the next, so comparing matters. Rx.com compares prices across more than 60,000 U.S. pharmacies so you can find today's lower price near you. Enter your ZIP above to see today's price on hydroxyzine HCl.

What is hydroxyzine HCl and how does it work?

Hydroxyzine hydrochloride is a first-generation antihistamine (a piperazine derivative). Along with blocking histamine, it has calming and sedative effects on the central nervous system, which is why it is used for more than allergies. It is FDA-approved for the symptomatic relief of anxiety and tension in psychoneurotic states and as an add-on in medical conditions where anxiety is present; for itching (pruritus) caused by allergic conditions such as chronic hives (urticaria), atopic dermatitis, and contact dermatoses; and as a sedative before and after surgery to help control nausea and vomiting and reduce the amount of narcotic pain medicine needed.

Doctors also commonly prescribe hydroxyzine off-label for short-term sleep trouble and for generalized anxiety, in part because it is non-habit-forming, unlike some other anxiety medicines. This page is for general information and is not medical advice; your prescriber decides whether hydroxyzine is right for you.

Hydroxyzine HCl cost without insurance and how to save

Hydroxyzine HCl is available as a generic, so it is generally inexpensive compared with brand-name medicines. There is no manufacturer savings card for this generic, and none is needed. The most reliable way to lower your out-of-pocket cost is to compare the cash price at pharmacies near you, because the same generic pill can cost noticeably more at one pharmacy than another.

Even if you have insurance, the cash price with an Rx.com discount can sometimes be lower than a copay, so it is worth checking both. We never post fixed dollar amounts here because prices change and are shown live. Enter your ZIP above to see today's price on hydroxyzine HCl across more than 60,000 pharmacies, then bring the lower price to the counter.

Hydroxyzine HCl vs. hydroxyzine pamoate and other alternatives

Hydroxyzine comes in two salt forms. Hydroxyzine hydrochloride (HCl) is the form covered on this page. Hydroxyzine pamoate, sold under the brand Vistaril, is a different salt of the same active drug and is used for very similar purposes; the older brand Atarax (hydroxyzine HCl) has been discontinued, though the generic remains widely available. Your prescriber may specify one salt form or the other.

Depending on what you are treating, other medicines are sometimes considered. For allergy itching, non-sedating antihistamines such as cetirizine or the older sedating antihistamine diphenhydramine may be options. For ongoing anxiety, buspirone is another non-habit-forming choice. Note that people allergic to cetirizine or levocetirizine should not take hydroxyzine. Always compare prices on the exact medicine you are prescribed, and let your provider choose the right one for you.

Safety, side effects, and precautions

Hydroxyzine has no boxed warning and is not a controlled substance, but there are important cautions. The label warns about QT prolongation and a rare heart-rhythm problem called Torsades de Pointes; it should be avoided in people with a prolonged QT interval, known heart-rhythm disorders, or who take other medicines that affect heart rhythm. Hydroxyzine is contraindicated in early pregnancy and in anyone allergic to hydroxyzine, cetirizine/levocetirizine, or aminophylline/ethylenediamine derivatives.

The most common effect is marked drowsiness, so do not drive or operate machinery until you know how it affects you, and avoid alcohol and other sedating medicines, since the effects add up. Hydroxyzine can also cause anticholinergic effects such as dry mouth, blurred vision, and trouble urinating; use extra caution in older adults and in people with glaucoma, an enlarged prostate, or bowel obstruction. Rare skin and allergic reactions can occur. This is a summary, not a full list. Tell your provider about all your conditions and medicines, and read the pharmacy leaflet that comes with your prescription.

Sources & accuracy

This Hydroxyzine Hcl information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Hydroxyzine Hcl on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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