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Jentadueto Xr Tablet Extended Release 24 Hour — prescription drug image

Jentadueto Xr

Jentadueto XR 2.5-1000MG

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What is Jentadueto Xr?

Jentadueto XR is a prescription medication used to manage blood sugar levels in adults with type 2 diabetes. It combines two active ingredients, linagliptin and metformin extended-release, which work together to improve glycemic control by increasing insulin secretion and decreasing sugar production in the liver. This medication is intended for use alongside diet and exercise to enhance blood sugar management.

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What is Jentadueto Xr ?

Jentadueto XR is a prescription medication used to manage blood sugar levels in adults with type 2 diabetes. It combines two active ingredients, linagliptin and metformin extended-release, which work together to improve glycemic control by increasing insulin secretion and decreasing sugar production in the liver. This medication is intended for use alongside diet and exercise to enhance blood sugar management.
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Fast or trouble breathing, severe weakness, tiredness, or confusion
  • Severe joint pain
  • Sudden and severe stomach pain, nausea, vomiting, fever
  • Trouble breathing, cold sweat, bluish-colored skin
  • Lightheadedness, dizziness, fainting
  • Increased hunger, headache, shaking, trembling, sweating
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, adrenal or pituitary gland disease, vitamin B12 deficiency, or a history of alcohol abuse, heart failure, or pancreas problems.
  • This medicine may cause the following problems:Lactic acidosis (too much acid in the blood, which can be life-threatening)PancreatitisHeart failureLow blood sugar, when used with other diabetes medicines
  • This medicine may cause some patients to become dehydrated. Drink plenty of water every day, during exercise, or in hot weather.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may interact with the dye used for an x-ray or a CT scan.
What is Jentadueto XR used for?
Jentadueto XR is used along with diet and exercise to improve blood sugar control in adults with type 2 diabetes. It combines linagliptin and extended-release metformin in one once-daily tablet.
Is there a generic version of Jentadueto XR?
No, there is currently no FDA-approved generic for Jentadueto XR. It's available only as the brand-name combination tablet.
What is the boxed warning for Jentadueto XR?
Jentadueto XR carries a boxed warning about metformin-associated lactic acidosis, a rare but serious condition. Risk factors include kidney problems, older age, heavy alcohol use, and certain other health conditions.
Can Jentadueto XR cause low blood sugar?
On its own, Jentadueto XR has a relatively low risk of causing hypoglycemia, but the risk increases when it's combined with insulin or medications like sulfonylureas that also lower blood sugar.
How is Jentadueto XR different from regular Jentadueto?
Jentadueto XR is an extended-release, once-daily tablet, while the original Jentadueto is taken twice daily as an immediate-release tablet. They are not automatically interchangeable; follow your prescriber's specific instructions.
How much does Jentadueto Xr cost without insurance?
The price of Jentadueto Xr without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 33% off retail prices with a free Rx.com coupon.
What are the common side effects of Jentadueto Xr?
Common side effects of Jentadueto Xr may include: Rapid weight gain, swelling in your hands, ankles, or feet, Fast or trouble breathing, severe weakness, tiredness, or confusion, Severe joint pain, Sudden and severe stomach pain, nausea, vomiting, fever, Trouble breathing, cold sweat, bluish-colored skin. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Jentadueto Xr?
Generic versions may be available for Jentadueto Xr. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Jentadueto Xr on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Jentadueto Xr?
The cheapest pharmacy for Jentadueto Xr depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Jentadueto Xr near you.

Jentadueto Xr Coupons & Prices

Jentadueto XR 2.5-1000MG

Prescriptions & Refills
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Jentadueto Xr Tablet Extended Release 24 Hour — prescription drug image
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Jentadueto Xr 5-1000mg er 24hr (xr) (7)
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Compounded GLP-1 medications are not FDA-approved and are prepared by state-licensed compounding pharmacies. They are not affiliated with, endorsed by, or equivalent to any brand-name medication or manufacturer. Prescription required; eligibility is determined by a licensed provider. Prices are estimates and may vary.

Searching for a Jentadueto XR coupon? Jentadueto XR is a once-daily, extended-release tablet that combines linagliptin and metformin to help adults with type 2 diabetes manage blood sugar alongside diet and exercise. Enter your ZIP above to see today's price at pharmacies near you.

What Is Jentadueto XR and How Does It Work?

Jentadueto XR combines two diabetes medicines in one extended-release tablet: linagliptin, a DPP-4 inhibitor that helps the body release more of its own insulin after meals, and metformin, which lowers how much sugar the liver releases and helps the body use insulin more effectively. It's approved as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus, taken once daily.

Jentadueto XR is available in two strengths: 2.5 mg linagliptin/1,000 mg metformin ER and 5 mg linagliptin/1,000 mg metformin ER, made by Boehringer Ingelheim.

Manufacturer Savings Card vs. an Rx.com Cash Coupon

Boehringer Ingelheim, the manufacturer of Jentadueto XR, may offer a savings card program through its official site, but manufacturer cards like this are typically limited to patients with commercial insurance and generally exclude Medicare and Medicaid, with terms that vary and can change. If you're uninsured, on Medicare, or your card is declined, an Rx.com cash coupon can be used at participating pharmacies instead. Boehringer Ingelheim also operates a patient assistance program for people who qualify and can't otherwise afford their medication; ask your prescriber's office about eligibility.

Is There a Generic Alternative?

There is no FDA-approved generic version of Jentadueto XR at this time; it remains available only as the brand-name product. Generic metformin extended-release is widely available on its own, and generic linagliptin is not yet marketed either, so patients and prescribers sometimes discuss whether taking generic metformin ER together with a separate DPP-4 inhibitor could be a lower-cost path, though that's a decision for your doctor, not a direct substitute for this combination tablet.

Safety Information

  • Jentadueto XR carries a boxed warning for metformin-associated lactic acidosis, a rare but serious buildup of lactic acid in the blood that can be life-threatening. Risk is higher with kidney problems, certain other medications, age 65 or older, recent contrast dye imaging, surgery, heavy alcohol use, or liver problems.
  • It's contraindicated in severe kidney impairment and in diabetic ketoacidosis or other metabolic acidosis.
  • Other risks include pancreatitis, low blood sugar when combined with insulin or certain other diabetes medicines, vitamin B12 deficiency with long-term use, and severe joint pain reported with linagliptin.

Seek emergency care for symptoms like unusual tiredness, muscle pain, trouble breathing, or stomach pain, which can signal lactic acidosis. This isn't a full list of warnings; talk with your doctor about your personal risk factors.

Sources & accuracy

This Jentadueto Xr information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Jentadueto Xr on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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