Leucovorin Calcium Coupons & Prices

Use a free Rx.com leucovorin calcium coupon to compare cash prices at more than 60,000 pharmacies before you fill. Leucovorin calcium is a prescription folic acid analog (a reduced folate). The tablets you pick up at a pharmacy are FDA-approved to reduce the toxicity of methotrexate in adults with impaired methotrexate elimination and to treat overdose of folic acid antagonists (DHFR inhibitors) in adults, and, since March 10, 2026, to treat cerebral folate transport deficiency in adults and children with a confirmed FOLR1 gene variant. The separate injectable form, given in a clinic, carries different approved uses, including rescue after high-dose methotrexate in osteosarcoma, megaloblastic anemia from folate deficiency, and use with fluorouracil in advanced colorectal cancer. The brand Wellcovorin is no longer marketed, so prescriptions are filled as the generic. Cash prices vary from pharmacy to pharmacy, so it pays to compare. Enter your ZIP above to see today's price near you.

What is leucovorin calcium and how does it work?

Leucovorin calcium is a folic acid analog, a reduced form of folate that cells can use right away without needing the enzyme that methotrexate and similar drugs block. Because of that, it does two very different jobs. It can act as an antidote and "rescue" agent, protecting healthy cells from the effects of folic acid antagonists (dihydrofolate reductase inhibitors) such as methotrexate, trimethoprim, and pyrimethamine. It can also act as a chemotherapy modulator: when given with fluorouracil (5-FU), it makes the fluorouracil work harder against the tumor, which is why it is a core component of the FOLFOX and FOLFIRI regimens used in advanced or metastatic colorectal cancer.

Approved uses depend on which form is being used, and the two labels are not the same. Leucovorin calcium tablets (the form this coupon is for) are FDA-approved to reduce the toxicity of methotrexate in adult patients with impaired methotrexate elimination and to reduce the toxicity of folic acid antagonists / DHFR inhibitors following overdose in adults, and to treat cerebral folate transport deficiency in adults and children with a confirmed folate receptor 1 (FOLR1) gene variant, an indication FDA granted on March 10, 2026 as the first approved therapy for that condition. Leucovorin calcium injection, which is given in a clinic or hospital, is separately approved for rescue after high-dose methotrexate therapy in osteosarcoma, to counteract impaired methotrexate elimination and inadvertent overdose of folic acid antagonists, for megaloblastic anemia due to folic acid deficiency when oral therapy is not feasible, and in combination with 5-fluorouracil to prolong survival in the palliative treatment of advanced colorectal cancer. The tablet label does not carry the osteosarcoma-rescue, megaloblastic anemia, or colorectal cancer indications. Leucovorin is prescription only, and it is not a controlled substance.

What leucovorin calcium costs without insurance, and how a coupon helps

Leucovorin calcium tablets are available as an FDA-approved generic. What you pay without insurance is not one national number: cash prices for the identical strength and quantity of the same generic can differ widely between a grocery-store pharmacy, a big chain, and an independent down the street, because each pharmacy sets its own cash price. Higher strengths and larger quantities can cost noticeably more than you might expect, so paying the first price you are quoted is how people overpay.

A free Rx.com coupon is a cash-discount price, not insurance. You show it at the pharmacy and pay the discounted cash price instead of the pharmacy's usual retail price. It can sometimes beat an insurance copay, but you cannot use both on the same fill, so it is worth checking your copay against the cash price. There is no manufacturer savings card for leucovorin calcium, since the brand is no longer marketed. Enter your ZIP above to see today's price at pharmacies near you and pick the lowest one before you fill. Note that the injectable form is normally given in a clinic or hospital and billed through that facility rather than picked up at a retail pharmacy.

Leucovorin, methotrexate, and related medicines

Leucovorin is not an alternative to methotrexate; it is usually given because of methotrexate. In high-dose chemotherapy, leucovorin is the planned rescue that limits methotrexate's toxicity to healthy tissue. If you are also pricing the methotrexate side of the regimen, you can compare cash prices for methotrexate, methotrexate sodium, and methotrexate (anti-rheumatic) the same way.

On brand versus generic: the original brand, Wellcovorin, is not marketed in the United States, and FDA withdrew GSK's Wellcovorin tablet application effective April 10, 2026 at the company's own request because the product was not being marketed. That was a business withdrawal, not a safety action, and FDA said it does not affect the availability of generic leucovorin or the cerebral folate transport deficiency labeling. In practice, generic leucovorin calcium tablets are what you fill, and they carry the FOLR1 cerebral folate transport deficiency indication.

There is no true over-the-counter substitute for leucovorin. Ordinary folic acid supplements are not interchangeable with it, and switching on your own could undermine a rescue schedule. The practical comparison here is not between different drugs but between pharmacies: the same generic leucovorin calcium tablet, at the same strength, can carry very different cash prices, so compare across the 60,000+ pharmacies in our network and bring the coupon that wins.

Safety, side effects, and interactions

Leucovorin calcium has no boxed warning on its current FDA labels, but it does carry serious warnings and it must be used exactly as prescribed. It is not indicated for pernicious anemia or other megaloblastic anemias caused by vitamin B12 deficiency, because it can improve the blood counts while nerve damage keeps getting worse. The tablets are also not recommended in people with methenyltetrahydrofolate synthetase (MTHFS) deficiency. The injectable form must never be given intrathecally (into the spinal fluid). Delayed or inadequate leucovorin rescue after high-dose methotrexate can be fatal, and rescue doses may need to be increased in people with delayed methotrexate elimination, kidney impairment, ascites, or other third-space fluid collections, so timing and dose changes are decisions for your care team, not something to adjust at home.

Leucovorin increases the toxicity of fluorouracil, including severe gastrointestinal toxicity, diarrhea, mouth sores, and low blood counts; deaths from severe enterocolitis, diarrhea, and dehydration have been reported in older adults receiving weekly leucovorin plus fluorouracil. Leucovorin can reduce the effectiveness of trimethoprim-sulfamethoxazole: adding it to trimethoprim-sulfamethoxazole for Pneumocystis jirovecii pneumonia in people with HIV was linked to more treatment failure and higher illness and death, so concomitant use is to be avoided. High doses may reduce the effectiveness of intrathecal methotrexate. Large amounts of folate can also counteract the antiseizure effect of phenobarbital, phenytoin, and primidone and increase seizure frequency, so seizure monitoring may need to be stepped up. Hypersensitivity reactions, including anaphylaxis and hives, have been reported; other common effects in combination regimens include nausea, vomiting, mucositis, and diarrhea. This page is information, not medical advice. Tell your provider and pharmacist about every medicine you take, and report new symptoms promptly.