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Linezolid Tablet — prescription drug image

Linezolid

Linezolid 600MG

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What is Linezolid?

Zyvox treats bacterial infections, including skin infections and pneumonia. The generic version of Zyvox is called linezolid. The average Zyvox price for a supply of 20, 600 mg oral tablets can be expensive at about $3,133. An easy way to reduce the Zyvox price is to use our free Rx.com discount card at a participating pharmacy near you.

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What is Linezolid ?

Zyvox treats bacterial infections, including skin infections and pneumonia. The generic version of Zyvox is called linezolid. The average Zyvox price for a supply of 20, 600 mg oral tablets can be expensive at about $3,133. An easy way to reduce the Zyvox price is to use our free Rx.com discount card at a participating pharmacy near you.
  • Diarrhea that contains blood
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet
  • Vision changes, trouble seeing
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Anxiety, restlessness, fast or uneven heartbeat, sweating, muscle spasms, stiffness, or twitching, diarrhea, seeing or hearing things that are not there
  • Unusual bleeding or bruising
  • Sleepiness or unusual drowsiness
  • Fever, chills, cough, sore throat, body aches
  • Fast breathing, trouble breathing, nausea and vomiting, lightheadedness, severe weakness, tiredness, or confusion
  • Seizures
  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, bone marrow problems, carcinoid syndrome, diabetes, pheochromocytoma (a tumor of the adrenal gland), thyroid problems, high blood pressure, other types of infection, or a history of seizures.
  • This medicine may cause the following problems:Lactic acidosis (too much lactic acid in the blood)Serotonin syndrome, when taken with certain medicinesNerve problems, especially in the eyes, hands, arms, legs, or feetHyponatremia (low sodium levels in the blood) or syndrome of inappropriate antidiuretic hormone secretion (SIADH)
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
  • The oral liquid contains phenylalanine (aspartame). Tell your doctor if you have phenylketonuria.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Talk with your doctor before using this medicine if you plan to have children. Some men who use this medicine have become infertile (unable to have children).
  • If your symptoms do not improve within 28 days or if they become worse, check with your doctor.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
What is linezolid used to treat?
Linezolid is FDA-approved to treat certain Gram-positive bacterial infections, including hospital-acquired (nosocomial) pneumonia, community-acquired pneumonia, and complicated and uncomplicated skin and skin-structure infections. It is active against resistant organisms such as MRSA and vancomycin-resistant Enterococcus faecium (VRE). Your prescriber decides whether it is right for your specific infection.
Is linezolid the same as Zyvox?
Yes. Linezolid is the generic version of the brand-name drug Zyvox. Both contain the same active ingredient and are held to the same FDA standards. The generic is typically much less expensive than the brand.
What foods and medications should you avoid while taking linezolid?
Linezolid acts as a monoamine oxidase inhibitor. It can interact with serotonergic drugs such as SSRIs, SNRIs, tricyclic antidepressants, triptans, and meperidine, and with adrenergic or dopaminergic medicines, raising the risk of serotonin syndrome or a hypertensive crisis. Patients are usually advised to avoid large amounts of tyramine-rich foods and drinks. Share your full medication list with your provider and pharmacist before starting.
How long can you safely take linezolid?
Your provider sets the length of treatment. Prolonged use, generally longer than 28 days, has been linked to peripheral and optic nerve damage that may be irreversible, and blood counts are often monitored weekly, especially past two weeks. Do not extend or stop your course on your own; follow your provider's instructions.
Does linezolid treat MRSA?
Yes. Linezolid is active against methicillin-resistant Staphylococcus aureus (MRSA), including in certain skin and skin-structure infections. Whether it is the best choice for a given MRSA infection is a decision for your prescriber.
How much does Linezolid cost without insurance?
The price of Linezolid without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Linezolid?
Common side effects of Linezolid may include: Diarrhea that contains blood, Numbness, tingling, or burning pain in your hands, arms, legs, or feet, Vision changes, trouble seeing, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Anxiety, restlessness, fast or uneven heartbeat, sweating, muscle spasms, stiffness, or twitching, diarrhea, seeing or hearing things that are not there. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Linezolid?
Generic versions may be available for Linezolid. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Linezolid on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Linezolid?
The cheapest pharmacy for Linezolid depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Linezolid near you.

Linezolid Coupons & Prices

Linezolid 600MG

Prescriptions & Refills
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Linezolid Tablet — prescription drug image
Prescription
Linezolid 600mg (6)
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Looking for a linezolid coupon? Linezolid is the generic form of Zyvox, an oxazolidinone antibiotic used to treat serious Gram-positive bacterial infections, including some that resist other antibiotics. Because it is available as a generic, linezolid is usually far less expensive than the brand, but the cash price can still vary a lot from one pharmacy to the next. Rx.com compares linezolid prices across more than 60,000 pharmacies so you can find a low price near you. Enter your ZIP above to see today's price and print or show a coupon at the pharmacy counter.

What is linezolid and how does it work?

Linezolid is an antibiotic in the oxazolidinone class. It is FDA-approved to treat certain Gram-positive bacterial infections, including hospital-acquired (nosocomial) pneumonia, community-acquired pneumonia, and complicated and uncomplicated skin and skin-structure infections. It is notably active against resistant organisms, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE). Linezolid works by stopping bacteria from making the proteins they need to grow and multiply.

Linezolid is the generic equivalent of the brand-name drug Zyvox. Generic and brand versions contain the same active ingredient and are held to the same FDA standards. Your prescriber decides which infections linezolid is right for; it is not a fit for every infection, and this page is general information, not medical advice.

Linezolid cost and savings without insurance

Because linezolid is available as a generic, it usually costs much less than the brand Zyvox. Even so, the cash price for the same prescription can differ widely between pharmacies, which is exactly why comparing prices matters. A Rx.com coupon can help whether or not you have insurance, and it may come out lower than an insurance copay for a generic like this one.

Rx.com compares linezolid prices across more than 60,000 pharmacies to help you find a low price nearby. There is no manufacturer savings card for generic linezolid. To see current pricing, enter your ZIP above; prices are shown live and can change, so check the price for your specific pharmacy, quantity, and formulation before you fill.

Alternatives and related antibiotics

Linezolid is one of several antibiotics used against resistant Gram-positive infections. The right choice depends on the specific infection, the organism, and your medical history, so this is a decision for your prescriber. Related medications people compare include:

  • Zyvox — the brand-name version of linezolid
  • vancomycin — often used for MRSA and other serious Gram-positive infections
  • daptomycin — another option for certain resistant Gram-positive infections
  • clindamycin — used for some skin and soft-tissue infections
  • doxycycline — a broad-spectrum antibiotic used for a range of infections

You can compare prices for any of these on Rx.com. Do not switch antibiotics on your own; only your provider should decide which one treats your infection.

Linezolid safety and important warnings

Linezolid does not carry a formal FDA boxed warning, but it does have several serious warnings your provider will weigh. It can lower blood cell counts (thrombocytopenia, anemia, leukopenia, or pancytopenia), so a CBC is often monitored weekly, especially with use beyond two weeks. Prolonged use (generally longer than 28 days) has been linked to peripheral and optic nerve damage that may be irreversible. Linezolid also acts as a monoamine oxidase inhibitor, so it can interact with serotonergic drugs (such as SSRIs, SNRIs, tricyclic antidepressants, triptans, and meperidine) and with adrenergic or dopaminergic agents, raising the risk of serotonin syndrome or a hypertensive crisis. Patients are usually advised to limit tyramine-rich foods and drinks.

Other reported effects include lactic acidosis, rare seizures, low blood sugar in people with diabetes taking insulin or oral diabetes medicines, and Clostridioides difficile-associated diarrhea. Linezolid generally is not recommended when close blood-pressure or serotonergic monitoring is not feasible. Give your provider and pharmacist a full list of your medicines and conditions, and call your provider about any concerning symptoms. This is general information, not medical advice.

Sources & accuracy

This Linezolid information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Linezolid on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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