NAD+ nasal spray, no needles
Starting at $99/mo on the 3-month plan
NAD+ is a coenzyme every cell uses to make energy and repair DNA, and your levels fall with age. Get a needle-free NAD+ nasal spray through a confidential online visit with a U.S.-licensed provider, at a fraction of the cost of IV drips.
- Needle-free, takes seconds a day
- U.S.-licensed providers
- Compounded by U.S. pharmacies
- Free shipping if prescribed
Your treatment
NAD+ Nasal Spray
Compounded nasal spray. 1 to 2 sprays per nostril, as your provider directs.
- Prescription required, provider reviewed
- Plans don't auto-renew
- No insurance or membership needed
Want a larger dose? See NAD+ injections
NAD+ without needles or an IV chair
A nasal spray delivers NAD+ through the lining of the nose in seconds, on a schedule your provider sets.
Energy and focus goals
People use NAD+ to support day-to-day energy, mental clarity and recovery as part of a healthy-aging routine.
Seconds, not hours
A couple of sprays take seconds at home, instead of a 2 to 4 hour drip in a clinic. No needles, ever.
A fraction of IV cost
IV NAD+ often costs hundreds of dollars per session. Here a full month starts at $99 on the 3-month plan.
What is NAD+?
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell in your body. Your mitochondria need it to turn food into ATP, the energy cells run on, and it fuels enzymes such as sirtuins and PARPs that help repair DNA and respond to stress.
NAD+ levels decline as we age, and researchers are studying whether restoring them supports energy, metabolism and healthy aging. A nasal spray delivers NAD+ through the lining of the nose, skipping the digestive system, with no needles involved.
The science is promising but early. Most human studies are small and short, very few have looked at nasal NAD+, and it is not approved to treat any condition. A provider reviews your health history and goals to decide whether it makes sense for you.
- Needle-free nasal spray
- Compounded by a licensed U.S. pharmacy
- Dose and schedule set by your provider
Nasal spray vs. injections vs. IV drips vs. supplements
These are the main ways people try to raise NAD+. Here is how they differ on cost, needles, time and oversight.
| Rx.com NAD+ nasal spray | NAD+ injection | IV drip at a clinic | NMN / NR supplements | |
|---|---|---|---|---|
| Cost | From $99/mo (3-month plan) | Same pricing at Rx.com | Often hundreds of dollars per session | Usually the cheapest option |
| Needles | None | Small under-the-skin needle | IV line | None |
| Time | Seconds at home | A few minutes at home | 2 to 4 hours in a chair | Seconds a day |
| What you take | NAD+ itself | NAD+ itself | NAD+ itself | Precursors the body converts to NAD+ |
| Prescription | Yes, provider reviewed | Yes, provider reviewed | Varies by clinic | No |
There is no good head-to-head evidence that one route works better than another; injections deliver a larger, more predictable dose, while the spray is easier to stick with. Supplements are a reasonable, lower-cost place to start; ask your provider what fits your goals.
What NAD+ does in your cells
NAD+ takes part in hundreds of chemical reactions. These are the three that get the most research attention.
Cellular energy
Mitochondria
NAD+ carries electrons in the mitochondria so cells can produce ATP. Lower NAD+ is linked in research to less efficient energy production.
DNA repair
PARP enzymes
PARP enzymes use NAD+ to repair everyday DNA damage. When NAD+ runs low, this repair work competes with other uses for it.
Stress response
Sirtuins
Sirtuins (such as SIRT1 and SIRT3) depend on NAD+ and help regulate metabolism, inflammation and how cells respond to stress.
Published studies on NAD+ and its precursors
Here is what researchers have actually looked at, in plain English.
NAD+ levels in human tissue were lower in older adults than in younger adults.
Massudi et al., PLoS One, 2012Researchers tracked how NAD+ and related compounds in blood and urine changed during a 6-hour NAD+ infusion in healthy men.
Grant et al., Frontiers in Aging Neuroscience, 2019Daily nicotinamide riboside, an NAD+ precursor, was well tolerated and raised NAD+ levels in healthy middle-aged and older adults.
Martens et al., Nature Communications, 2018Nicotinamide mononucleotide, another NAD+ precursor, improved muscle insulin sensitivity in women with prediabetes.
Yoshino et al., Science, 2021Most of this research used oral precursors or IV NAD+, not nasal spray, and none of it shows NAD+ treats or prevents a disease. Results vary from person to person.
Use it exactly as prescribed
A typical schedule is 1 to 2 sprays in each nostril, once or twice a day. Your provider sets the dose and your prescription label has the instructions. Many people use it in the morning, and some start lower and build up to limit irritation or flushing.
NAD+ is not a substitute for the basics. Sleep, exercise and diet still do most of the work in any healthy-aging plan.
Good to know
- Gently blow your nose before spraying
- Keep your head upright and breathe in softly as you spray
- Mild burning or a runny nose is common and usually passes
- Store the bottle as directed on the label
- Never use more than prescribed
From couch to doorstep in 3 steps
100% online, with free shipping if a prescription is approved.
Answer a health questionnaire
A short, confidential online intake about your health history and goals.
A provider reviews it
A U.S.-licensed provider decides whether NAD+ nasal spray is appropriate for you, and at what dose.
Get your medication
A licensed U.S. pharmacy compounds your prescription and ships it to your door.
NAD+ nasal spray FAQs
What is NAD+ nasal spray?
What is it used for?
Is NAD+ nasal spray FDA-approved?
How do I use it?
Nasal spray or injection: which is better?
What side effects can it cause?
How soon will I notice anything?
Who should not use NAD+ nasal spray?
Do I need a prescription?
Does insurance cover it?
See if NAD+ nasal spray is right for you
Complete a short online visit and a licensed provider will decide whether NAD+ fits your health history and goals. Plans start at $99/mo and never auto-renew.
Get Started
Important safety information
NAD+ nasal spray is a compounded medication. Compounded medications are not FDA-approved, and the FDA has not reviewed them for safety, effectiveness or quality. NAD+ is not approved to diagnose, treat, cure or prevent any disease, and statements on this page have not been evaluated by the FDA.
Common side effects include nasal irritation or burning, runny nose or sneezing, flushing, headache and lightheadedness; nausea and fatigue are less common. Stop using it and contact your provider if you get nosebleeds or lasting nasal pain. Do not use NAD+ if you are pregnant or breastfeeding. Tell the provider about all your health conditions, including any history of cancer, and every medication and supplement you take. Get medical care right away for signs of an allergic reaction such as hives, swelling of the face or throat, or trouble breathing.
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Prescription required: Medications are only prescribed when clinically appropriate after a provider evaluation. This page is for information and is not a substitute for professional medical advice.
Research: Studies cited above are summarized for general information; they examined NAD+ biology, IV NAD+ or oral NAD+ precursors and do not show that Rx.com's NAD+ nasal spray produces any specific result.
Medical services: All medical services, including clinical evaluations, treatment planning and prescribing decisions, are provided exclusively by licensed independent medical providers. Rx.com provides the technology platform and administrative coordination services, does not employ healthcare providers, and does not practice medicine.
