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Healthy aging

NAD+ nasal spray, no needles

NAD+ is a coenzyme your cells use to make energy and repair DNA, and levels fall with age. Get a needle-free NAD+ nasal spray through a confidential online visit with a U.S.-licensed provider.

  • Needle-free, takes seconds a day
  • 100% online, confidential visit
  • Reviewed by U.S.-licensed providers
  • Compounded by licensed U.S. pharmacies, shipped free
  • No insurance or membership needed

Your treatment

NAD+ Nasal Spray

Compounded nasal spray. 1 to 2 sprays per nostril, as your provider directs.

Get Started
  • Prescription required, provider reviewed
  • Save on 3, 6 and 12 month plans
  • Plans don't auto-renew
  • Free shipping if prescribed

Want a larger dose? See NAD+ injections

Upfront pricing Free delivery No membership fees U.S.-licensed providers No insurance needed

What is NAD+?

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell in your body. Your mitochondria need it to turn food into ATP, the energy cells run on, and it fuels enzymes such as sirtuins and PARPs that help repair DNA and respond to stress.

NAD+ levels decline as we age, and researchers are studying whether restoring them supports energy, metabolism and healthy aging. A nasal spray delivers NAD+ through the lining of the nose, skipping the digestive system, with no needles involved.

The science is promising but early. Most human studies are small and short, very few have looked at nasal NAD+, and it is not approved to treat any condition. A provider reviews your health history and goals to decide whether it makes sense for you.

People use NAD+ for goals like:

  • Day-to-day energy and stamina
  • Mental clarity and focus
  • Recovery from exercise and sleep quality
  • Supporting a broader healthy-aging routine
How it works

What NAD+ does in your cells

NAD+ takes part in hundreds of chemical reactions. These are the three that get the most research attention.

01

Cellular energy

Mitochondria

NAD+ carries electrons in the mitochondria so cells can produce ATP. Lower NAD+ is linked in research to less efficient energy production.

02

DNA repair

PARP enzymes

PARP enzymes use NAD+ to repair everyday DNA damage. When NAD+ runs low, this repair work competes with other uses for it.

03

Stress response

Sirtuins

Sirtuins (such as SIRT1 and SIRT3) depend on NAD+ and help regulate metabolism, inflammation and how cells respond to stress.

How to use it

Use it exactly as prescribed

A typical schedule is 1 to 2 sprays in each nostril, once or twice a day. Your provider sets the dose and your prescription label has the instructions. Many people use it in the morning, and some start lower and build up to limit irritation or flushing.

NAD+ is not a substitute for the basics. Sleep, exercise and diet still do most of the work in any healthy-aging plan.

Good to know

  • Gently blow your nose before spraying
  • Keep your head upright and breathe in softly as you spray
  • Mild burning or a runny nose is common and usually passes
  • Store the bottle as directed on the label
  • Never use more than prescribed

Get started in 3 steps

100% online, with free shipping if a prescription is approved.

1

Answer a health questionnaire

A short, confidential online intake about your health history and goals.

2

A provider reviews it

A U.S.-licensed provider decides whether NAD+ nasal spray is appropriate for you, and at what dose.

3

Get your medication

A licensed U.S. pharmacy compounds your prescription and ships it to your door.

NAD+ nasal spray FAQs

What is NAD+ nasal spray?
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell that helps turn food into energy and is used by enzymes involved in DNA repair. NAD+ nasal spray is a compounded prescription that delivers NAD+ through the lining of the nose, so there are no needles.
What is it used for?
People most often use NAD+ nasal spray for energy, focus and healthy-aging goals. Research on NAD+ is promising but still early, very little of it has looked at the nasal route specifically, and NAD+ has not been proven to treat or prevent any disease. A provider will talk through what you can realistically expect.
Is NAD+ nasal spray FDA-approved?
No. NAD+ nasal spray is a compounded medication prepared by a licensed U.S. pharmacy for an individual prescription. Compounded medications are not FDA-approved, which means the FDA has not reviewed them for safety, effectiveness or quality.
How do I use it?
A typical schedule is 1 to 2 sprays in each nostril, once or twice a day, but follow the dose on your prescription label. Gently blow your nose first, keep your head upright, spray while breathing in softly, and avoid blowing your nose right after. Many people use it in the morning, since some find it energizing.
Nasal spray or injection: which is better?
The nasal spray is needle-free and quick to use, which makes it easier to stick with. The injection delivers a larger, more predictable dose into the body. There are no good head-to-head studies, so the choice usually comes down to your comfort with needles and your goals. A provider can help you decide, and Rx.com offers both. See NAD+ injections.
What side effects can it cause?
The most common are nasal irritation or mild burning, a runny nose or sneezing, temporary flushing or warmth, and a mild headache or lightheadedness. Nausea and tiredness are less common. These are usually mild and often ease as you get used to it or with a lower dose.
How soon will I notice anything?
It varies. Some people say they feel more alert within the first few days, and others notice little change. Because the research is limited, there is no guaranteed timeline or result. Tell your provider how you feel so they can adjust your plan.
Who should not use NAD+ nasal spray?
NAD+ is not recommended during pregnancy or breastfeeding because it has not been studied there. Tell your provider if you have cancer or a history of cancer, frequent nosebleeds or other nasal problems, heart, liver or kidney disease, or take other medications, so they can decide whether it is appropriate for you.
Do I need a prescription?
Yes. You complete an online health questionnaire, a U.S.-licensed provider reviews it, and if treatment is appropriate a licensed U.S. pharmacy fills your prescription and ships it to you.
Does insurance cover it?
No insurance is needed. NAD+ nasal spray is cash pay with upfront pricing: from $99 a month on a prepaid 3, 6 or 12 month plan, or $179 for a single month. Plans do not auto-renew. Most insurance plans do not cover compounded NAD+. You may be able to use an HSA or FSA card; check with your plan administrator.

See if NAD+ is right for you

Complete a short online visit and a licensed provider will decide whether NAD+ nasal spray fits your health history and goals.

Get Started

Important safety information

NAD+ nasal spray is a compounded medication. Compounded medications are not FDA-approved, and the FDA has not reviewed them for safety, effectiveness or quality. NAD+ is not approved to diagnose, treat, cure or prevent any disease, and statements on this page have not been evaluated by the FDA.

Common side effects include nasal irritation or burning, runny nose or sneezing, flushing, headache and lightheadedness; nausea and fatigue are less common. Stop using it and contact your provider if you get nosebleeds or lasting nasal pain. Do not use NAD+ if you are pregnant or breastfeeding. Tell the provider about all your health conditions, including any history of cancer, and every medication and supplement you take. Get medical care right away for signs of an allergic reaction such as hives, swelling of the face or throat, or trouble breathing.

Articles & Guides

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Prescription required: Medications are only prescribed when clinically appropriate after a provider evaluation. This page is for information and is not a substitute for professional medical advice.

Medical services: All medical services, including clinical evaluations, treatment planning and prescribing decisions, are provided exclusively by licensed independent medical providers. Rx.com provides the technology platform and administrative coordination services, does not employ healthcare providers, and does not practice medicine.

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