Naloxone Hcl
Naloxone HCl 2 Liquid
What is Naloxone Hcl?
Naloxone HCl, often marketed under the brand name Narcan among others, is a medication primarily used to counteract life-threatening depression of the central nervous system and respiratory system caused by opioid overdoses. It works by competitively blocking opioid receptors, rapidly reversing the effects of opioid drugs. Administered via injection or nasal spray, Naloxone HCl is a critical tool in emergency responses to opioid overdoses, capable of restoring normal breathing to a person whose breathing has slowed or stopped as a result of overdosing with heroin or prescription opioid pain medications.Side Effects
- Lightheadedness, dizziness, fainting
- Crying more than usual (in babies)
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Warnings
- Ongoing trouble breathing
- This medicine could cause withdrawal symptoms from the opioid medicine.
- The effects of the opioid medicine may last longer than the effects of the naloxone. This means the breathing problems and sleepiness could come back. Always call for emergency help after the first dose of naloxone.
- Tell your doctor if you are pregnant or breastfeeding, or if you have heart or blood vessel disease.
- This medicine should be given right away after a suspected or known overdose of an opioid (narcotic) medicine. This will help prevent serious breathing problems and severe sleepiness that can lead to death.
Prescription savings · · · ·
What is Naloxone Hcl ?
Naloxone HCl, often marketed under the brand name Narcan among others, is a medication primarily used to counteract life-threatening depression of the central nervous system and respiratory system caused by opioid overdoses. It works by competitively blocking opioid receptors, rapidly reversing the effects of opioid drugs. Administered via injection or nasal spray, Naloxone HCl is a critical tool in emergency responses to opioid overdoses, capable of restoring normal breathing to a person whose breathing has slowed or stopped as a result of overdosing with heroin or prescription opioid pain medications.- Lightheadedness, dizziness, fainting
- Crying more than usual (in babies)
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Fever, runny nose, sneezing, sweating, yawning, discomfort in the nose
- Fast, pounding, or uneven heartbeat
- Ongoing trouble breathing
- Unusual tiredness or weakness
- Diarrhea, nausea, vomiting, stomach cramps or pain
- Seizure, shaking, or feeling restless, nervous, or irritable
- Ongoing trouble breathing
- This medicine could cause withdrawal symptoms from the opioid medicine.
- The effects of the opioid medicine may last longer than the effects of the naloxone. This means the breathing problems and sleepiness could come back. Always call for emergency help after the first dose of naloxone.
- Tell your doctor if you are pregnant or breastfeeding, or if you have heart or blood vessel disease.
- This medicine should be given right away after a suspected or known overdose of an opioid (narcotic) medicine. This will help prevent serious breathing problems and severe sleepiness that can lead to death.
- Seizure, shaking, or feeling restless, nervous, or irritable
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Naloxone Hcl Coupons & Prices
Naloxone HCl 2 Liquid
Weight-loss medication, prescribed online
Licensed U.S. providers · No insurance needed · Shipped to your door
Naloxone Hcl prices by dosage
Lowest cash price with a free Rx.com coupon vs. the average retail price.
| Dosage | Quantity | Retail price | Rx.com price |
|---|---|---|---|
| 2 liquid · Box | 2 | $95.99 | $29.51 |
Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.
Searching for a naloxone hcl coupon? Naloxone hydrochloride, sold under brand names like Narcan and available as a lower-cost generic, is the medicine used to reverse an opioid overdose in an emergency, and pharmacy prices for it vary widely from one location to the next. Rx.com compares pricing across more than 60,000 U.S. pharmacies, so before you fill a prescription or pick up an over-the-counter naloxone nasal spray, enter your ZIP above to see today's price near you.
What is naloxone and how does it work
Naloxone hydrochloride is an opioid antagonist: it works by attaching to the same receptors in the brain that opioids attach to, blocking or reversing their effects. It is FDA-approved for the emergency treatment of known or suspected opioid overdose, in adults and children, when breathing or the central nervous system is being depressed. Naloxone is not a controlled substance and has no abuse potential; if opioids are not present in a person's system, it has essentially no effect.
Naloxone comes in a few forms: nasal sprays (available in a few different strengths) and injectable versions, including auto-injectors and generic injection solutions. More than one naloxone nasal spray is now approved for sale over the counter, without a prescription, including Narcan 4mg nasal spray, a generic 4mg naloxone nasal spray, and RiVive 3mg nasal spray; other naloxone strengths and the injectable forms are generally prescription products or are distributed through community naloxone programs.
Naloxone HCl cost and how to save
Because a generic version of naloxone is available and some naloxone nasal sprays can be bought over the counter, cost can differ quite a bit depending on which pharmacy you use, whether you buy a brand-name or generic product, and which strength or form you need. Prices are not the same everywhere, so it pays to compare before you buy.
Rx.com checks pricing across 60,000-plus pharmacies nationwide so you can see how the same naloxone product is priced at pharmacies near you and pick the lowest option. Enter your ZIP code above to see today's price for naloxone hcl at pharmacies in your area.
Narcan vs. generic naloxone and other options
Narcan is the best-known brand name for naloxone nasal spray, but a generic naloxone nasal spray is also available and contains the same active ingredient at the same strength. Other naloxone brand names on the market include Kloxxado, RiVive, and Zimhi (an injectable). Because these products differ in strength, delivery method (nasal spray vs. injection), and prescription status, check the label or ask your pharmacist which one matches what was recommended for you.
If you or someone you know is being treated for opioid use disorder, you may also want to compare pricing on related medications such as buprenorphine, Suboxone, and methadone, or look up Narcan directly.
Naloxone safety information
Naloxone only reverses the effects of opioids and does not treat overdoses from other substances. In a person who is physically dependent on opioids, naloxone can trigger acute withdrawal symptoms such as agitation, pain, a fast heartbeat, or vomiting. Its effects can wear off sooner than the opioid causing the overdose, so breathing problems can return after naloxone is given.
Always call emergency medical services right away in a suspected overdose, and keep monitoring the person; additional doses may be needed every 2 to 3 minutes until help arrives. This information is general and not a substitute for medical advice — talk to a healthcare provider or pharmacist about naloxone use for your situation.
This Naloxone Hcl information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Naloxone Hcl on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.
