Orphenadrine Citrate Er
Orphenadrine Citrate ER 100MG
What is Orphenadrine Citrate Er?
Orphenadrine citrate ER is a medication primarily used to relieve muscle pain and discomfort. It works as a muscle relaxant and is often prescribed alongside rest and physical therapy. Users can connect with licensed providers for prescriptions on Rx.com, offering options like mail-order and savings cards to manage costs effectively.Side Effects
- Weakness, tremors, or shaking.
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Confusion, anxiety, unusual thoughts, or hallucinations (seeing things that are not there).
Warnings
- Make sure your doctor knows if you are pregnant or breast feeding, or if you have heart problems.
- This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Lightheadedness or fainting.
Prescription savings · · · ·
What is Orphenadrine Citrate Er ?
Orphenadrine citrate ER is a medication primarily used to relieve muscle pain and discomfort. It works as a muscle relaxant and is often prescribed alongside rest and physical therapy. Users can connect with licensed providers for prescriptions on Rx.com, offering options like mail-order and savings cards to manage costs effectively.- Weakness, tremors, or shaking.
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Confusion, anxiety, unusual thoughts, or hallucinations (seeing things that are not there).
- Fast, pounding, or uneven heartbeat.
- Lightheadedness or fainting.
- Trouble urinating, or a decrease in how much or how often you urinate.
- Make sure your doctor knows if you are pregnant or breast feeding, or if you have heart problems.
- This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Lightheadedness or fainting.
Orphenadrine Citrate Er Coupons & Prices
Orphenadrine Citrate ER 100MG
4 ED medications in one dose
Sildenafil, tadalafil, PT-141 & L-Citrulline · Works in ~15 min · Lasts up to 36 hours
Use an orphenadrine citrate ER coupon from Rx.com to compare cash prices on extended-release orphenadrine citrate 100 mg tablets at more than 60,000 pharmacies near you. Orphenadrine citrate is a centrally acting skeletal muscle relaxant used short-term, alongside rest and physical therapy, for the discomfort of acute painful musculoskeletal conditions such as muscle spasm, strains, sprains, and low back pain. The brand Norflex is no longer marketed in the United States, but an FDA-approved generic extended-release tablet is available, and what you pay in cash can vary widely from one pharmacy to the next. Enter your ZIP code above to see today's price at pharmacies around you.
What is orphenadrine citrate ER and how does it work?
Orphenadrine citrate is a centrally acting skeletal muscle relaxant. It is chemically an analog of diphenhydramine and carries anticholinergic and antihistaminic properties. The FDA label states that its exact mode of action has not been clearly identified, but the effect may be related to its analgesic (pain-relieving) properties. It does not work directly on the muscle itself the way a topical rub does.
It is FDA-approved as an adjunct to rest, physical therapy, and other measures for relief of discomfort associated with acute, painful musculoskeletal conditions. The standard dose of the extended-release tablet is one 100 mg tablet twice a day, morning and evening. Extended-release tablets must be swallowed whole and should not be crushed or chewed, because that would release the whole dose at once. The label states that the safety of continuous long-term therapy has not been established, and safety in children has not been established. Your prescriber decides how long you should take it.
What orphenadrine citrate ER costs without insurance, and how to pay less
Orphenadrine citrate ER is a generic medicine, and there is no manufacturer savings card for it. That does not mean every pharmacy charges the same. Cash prices for the same generic tablet, the same strength, and the same quantity can differ a great deal between a chain drugstore, a grocery-store pharmacy, and an independent down the street. That gap is the reason comparing is worth the two minutes it takes.
Rx.com compares cash prices across more than 60,000 U.S. pharmacies and gives you a free coupon you can show at the counter. The coupon is a cash-discount tool, not insurance. If you do have prescription coverage, ask the pharmacist to run both your insurance and the coupon and use whichever comes out lower for you that day, since a plan copay is sometimes higher than the cash price on an inexpensive generic. Enter your ZIP code above to see today's price near you, and check the quantity your prescriber wrote, because a 30-day and a 90-day fill can price out very differently per tablet.
Orphenadrine compared with other muscle relaxants
Orphenadrine is one of several muscle relaxants prescribers use for short-term musculoskeletal pain. There is no single best one for everyone, and the choice usually comes down to your other conditions, your other medicines, and how sedating each one is for you. Other options your prescriber may discuss include:
- cyclobenzaprine, a commonly prescribed alternative
- methocarbamol and metaxalone
- chlorzoxazone
- tizanidine and baclofen, which are also used for spasticity
- carisoprodol and diazepam, which are controlled substances
Orphenadrine is also sold in combination products that pair it with aspirin and caffeine. The brand marketed in the United States is Orphengesic Forte; the older Norgesic and Norgesic Forte brands are no longer marketed here. Combination products are different prescriptions with their own labels and their own prices, so if your prescriber wrote for a combination product, price that exact product rather than the single-ingredient ER tablet. Never switch between muscle relaxants on your own. Ask your prescriber or pharmacist which fits your situation.
Safety information you should know
Orphenadrine citrate ER has no boxed warning, but it has real limits. It should not be used if you have glaucoma, pyloric or duodenal obstruction, stenosing peptic ulcer, prostate enlargement or bladder-neck obstruction, cardiospasm (megaesophagus), or myasthenia gravis. The label describes its adverse reactions as mostly due to its mild anticholinergic action and usually associated with higher dosages. Those anticholinergic effects are common, especially at higher doses: dry mouth, blurred vision, difficulty urinating, constipation, fast heartbeat or palpitations, and in some people confusion. It can also cause temporary light-headedness, dizziness, fainting, and drowsiness, so do not drive or operate machinery until you know how it affects you. Alcohol and other medicines that slow you down, including opioids, sleep aids, and sedating antihistamines, intensify those effects.
Orphenadrine appears on the American Geriatrics Society Beers Criteria as potentially inappropriate for adults 65 and older, because of its anticholinergic burden, limited proven benefit, and fall risk. The label reports very rare cases of aplastic anemia in people taking orphenadrine, while noting that no causal relationship has been established. Because the safety of continuous long-term therapy has not been established, the label recommends periodic monitoring of blood, urine, and liver function values if the drug is prescribed for prolonged use. Use caution with a fast heart rate, cardiac decompensation, coronary insufficiency, or arrhythmias, and with liver or kidney problems. Overdose can be fatal. Keep it away from children, and get emergency help if too much is taken. This page is general information, not medical advice. Give your prescriber and pharmacist your full medicine list and talk with them about whether this drug is right for you.
This Orphenadrine Citrate Er information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Orphenadrine Citrate Er on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
Related Drugs
Browse more medications: starting with O · full A-Z directory · by condition · common drugs
Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.