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Penicillin V Potassium Tablet — prescription drug image

Penicillin V Potassium

Penicillin V Potassium 500MG

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What is Penicillin V Potassium?

Penicillin V Potassium is a generic drug used in the treatment of different types of bacterial infections including pneumonia and scarlet fever. The average Penicillin V Potassium price is about $27 for a supply of 28, 500 mg oral tablets. You can use our Rx.com savings offer to get a Penicillin V Potassium discount of up to 80% at participating pharmacies near you.

Prescription savings · · · ·

What is Penicillin V Potassium ?

Penicillin V Potassium is a generic drug used in the treatment of different types of bacterial infections including pneumonia and scarlet fever. The average Penicillin V Potassium price is about $27 for a supply of 28, 500 mg oral tablets. You can use our Rx.com savings offer to get a Penicillin V Potassium discount of up to 80% at participating pharmacies near you.
  • Severe diarrhea, fever, stomach cramps
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Tell your doctor if you are pregnant or breastfeeding, or if you have asthma, allergies, kidney disease, liver disease, or digestion problems. Tell your doctor if you had an allergic reaction to a cephalosporin antibiotic.
  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
  • Call your doctor if your symptoms do not improve or if they get worse.
What is penicillin V potassium used to treat?
Penicillin V potassium is FDA-approved for mild-to-moderate infections caused by penicillin-susceptible bacteria. These include strep throat (streptococcal pharyngitis) and other upper respiratory infections, scarlet fever, mild erysipelas, mild-to-moderate skin and soft-tissue infections, and Vincent's infection of the mouth and throat. It is also used to help prevent the return of rheumatic fever and, in certain heart patients, to help prevent bacterial endocarditis before dental or upper-respiratory procedures. It is not used for severe infections such as pneumonia, bacteremia, or meningitis.
Is penicillin VK the same as amoxicillin?
No. Both are penicillin-family (beta-lactam) antibiotics, but they are different drugs. Penicillin V potassium (penicillin VK) is a natural penicillin, while amoxicillin is a broader-spectrum aminopenicillin that covers a wider range of bacteria and is often dosed differently. Your prescriber picks between them based on the type of infection. They are not interchangeable on your own.
Should you take penicillin V potassium with food or on an empty stomach?
Penicillin V potassium is best absorbed on an empty stomach, so it is generally taken about an hour before or two hours after a meal, unless your prescriber or pharmacist tells you otherwise. Take it exactly as directed and finish the entire course, even if you feel better, to help keep the infection from coming back and to reduce the risk of antibiotic resistance.
What are the most common side effects of penicillin V potassium?
The most common side effects are usually mild and involve the stomach, such as nausea, vomiting, and diarrhea, along with hypersensitivity reactions like rash or hives. More serious but less common issues include severe allergic (anaphylactic) reactions and Clostridioides difficile-associated diarrhea, which can appear even weeks after treatment. Contact your provider right away if you have a severe rash, swelling, trouble breathing, or persistent or bloody diarrhea. This is not a complete list; ask your pharmacist for full details.
How long does it take for penicillin V potassium to work for strep throat?
Many people with strep throat start to feel better within a day or two of starting penicillin V potassium, but you should still take the full course exactly as prescribed. Stopping early, even once symptoms improve, can let the infection return and can contribute to antibiotic resistance. If you are not improving after a few days or feel worse, contact your prescriber.
How much does Penicillin V Potassium cost without insurance?
The price of Penicillin V Potassium without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Penicillin V Potassium?
Common side effects of Penicillin V Potassium may include: Severe diarrhea, fever, stomach cramps, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Blistering, peeling, red skin rash. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Penicillin V Potassium?
Generic versions may be available for Penicillin V Potassium. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Penicillin V Potassium on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Penicillin V Potassium?
The cheapest pharmacy for Penicillin V Potassium depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Penicillin V Potassium near you.

Penicillin V Potassium Coupons & Prices

Penicillin V Potassium 500MG

Prescriptions & Refills
Licensed US providers · Online visit in minutes
Penicillin V Potassium Tablet — prescription drug image
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Penicillin V Potassium 500mg (24)
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Looking for a penicillin V potassium coupon? Penicillin V potassium (once sold under brand names like Veetids and Pen-Vee K, all discontinued in the US and now available as a generic only) is a low-cost natural penicillin antibiotic used to treat mild-to-moderate bacterial infections such as strep throat. Because it is generic, the cash price is already modest, but what you pay can vary widely from one pharmacy to the next. Enter your ZIP above to see today's price and compare across more than 60,000 pharmacies so you can pick up your prescription for less.

What is penicillin V potassium and how does it work?

Penicillin V potassium is a natural penicillin antibiotic in the beta-lactam family. It works by attacking the cell walls of penicillin-susceptible (penicillin G-sensitive) bacteria, stopping them from growing so your body can clear the infection. It is FDA-approved for mild-to-moderate infections, including upper respiratory tract infections such as streptococcal pharyngitis ("strep throat"), scarlet fever, mild erysipelas, mild-to-moderate skin and soft-tissue infections, and Vincent's infection (fusospirochetosis) of the mouth and throat. It is also used to help prevent the recurrence of rheumatic fever and, per American Heart Association guidance, to help prevent bacterial endocarditis in certain heart patients undergoing dental or upper-respiratory procedures.

It is not intended for severe infections such as pneumonia, bacteremia, meningitis, or arthritis in the acute stage, which require different treatment. Your prescriber will decide whether penicillin V potassium is right for your specific infection.

How much does penicillin V potassium cost without insurance?

The brand-name versions of penicillin V potassium have all been discontinued in the US, so today it is available only as a generic. Generics like this are already among the most affordable antibiotics, but that does not mean every pharmacy charges the same. Cash prices can differ significantly between pharmacies in the same town, which is exactly why comparing matters, especially if you do not have insurance or your plan does not cover it well.

Rx.com compares live cash prices across more than 60,000 pharmacies so you can see where it costs the least near you. Enter your ZIP above to see today's price, then show the coupon at the pharmacy counter. There is no membership fee to use it.

Related antibiotics and alternatives

Penicillin V potassium is one of several antibiotics a prescriber may choose depending on the type of infection and any allergies you have. Other commonly prescribed options include amoxicillin, amoxicillin-clavulanate, cephalexin, azithromycin, and clindamycin. For people with a penicillin allergy, a non-penicillin option such as azithromycin or clindamycin is often used instead.

Only your prescriber can decide which antibiotic fits your infection, so never switch on your own. If you are prescribed a different drug, you can compare its price on Rx.com the same way.

Safety and side effects

Penicillin V potassium has no boxed warning, but it should not be used by anyone with a history of penicillin or other beta-lactam allergy. Serious and occasionally fatal allergic (anaphylactic) reactions can occur, and they are more likely in people with a history of penicillin sensitivity or multiple allergies; there is also a possibility of cross-reactivity with cephalosporin antibiotics. Tell your provider about any drug allergies before starting. Antibiotics like this can also cause Clostridioides difficile-associated diarrhea, which ranges from mild diarrhea to serious colitis and can begin even weeks after you finish the medicine.

For best absorption, take penicillin V potassium on an empty stomach, and finish the full course even if you feel better, to help prevent resistance. The most common side effects are usually mild and include nausea, vomiting, diarrhea, and rash or hives. This is general information and not medical advice; talk with your doctor or pharmacist about your specific situation and report any severe rash, swelling, trouble breathing, or persistent diarrhea right away.

Sources & accuracy

This Penicillin V Potassium information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Penicillin V Potassium on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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