Premphase
Premphase 28 Tablets
What is Premphase?
Premphase is a prescription medication combining estrogen and progestin, primarily used for hormone replacement therapy in postmenopausal women. It helps alleviate menopausal symptoms such as hot flashes and vaginal dryness, offering a balanced approach to hormonal health. For convenient access, you can check prescription online options, find savings coupons, and explore mail-order refills at Rx.com.Side Effects
- Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking
- Swelling in your face, hands, ankles, or feet
- Seizures
Warnings
- Tell your doctor if you have endometriosis or a history of cancer. Tell your doctor if you have asthma, diabetes, epilepsy, gallbladder, heart, or kidney disease, high or low calcium, lupus, migraine headaches, porphyria, or thyroid problems. Tell your doctor if you have high blood pressure, high cholesterol, a family history of high cholesterol, or a history of liver problems caused by pregnancy or estrogen.
- This medicine may increase your risk for the following: DementiaHeart attack, blood clots, or stroke, especially if you smoke, have diabetes or high cholesterol, or are overweightBreast or ovarian cancerUterine cancer if you take this medicine without a progestin medicine
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Stop taking this medicine and check with your doctor immediately if you have a severe headache or sudden loss of vision or vision changes. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).
- Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
Prescription savings · · · ·
What is Premphase ?
Premphase is a prescription medication combining estrogen and progestin, primarily used for hormone replacement therapy in postmenopausal women. It helps alleviate menopausal symptoms such as hot flashes and vaginal dryness, offering a balanced approach to hormonal health. For convenient access, you can check prescription online options, find savings coupons, and explore mail-order refills at Rx.com.- Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking
- Swelling in your face, hands, ankles, or feet
- Seizures
- Pain in your calf
- Unusual vaginal bleeding
- Yellow skin or eyes
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Chest pain, trouble breathing, or coughing up blood
- Breast changes, lumps, or discharge (in women or men)
- Tell your doctor if you have endometriosis or a history of cancer. Tell your doctor if you have asthma, diabetes, epilepsy, gallbladder, heart, or kidney disease, high or low calcium, lupus, migraine headaches, porphyria, or thyroid problems. Tell your doctor if you have high blood pressure, high cholesterol, a family history of high cholesterol, or a history of liver problems caused by pregnancy or estrogen.
- This medicine may increase your risk for the following: DementiaHeart attack, blood clots, or stroke, especially if you smoke, have diabetes or high cholesterol, or are overweightBreast or ovarian cancerUterine cancer if you take this medicine without a progestin medicine
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Stop taking this medicine and check with your doctor immediately if you have a severe headache or sudden loss of vision or vision changes. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).
- Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments. Pelvic exam, breast exam, and mammogram (breast x-ray) may be needed to check for side effects.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Yellow skin or eyes
Premphase Coupons & Prices
Premphase 28 Tablets
Premphase prices by dosage
Lowest cash price with a free Rx.com coupon vs. the average retail price.
| Dosage | Quantity | Retail price | Rx.com price |
|---|---|---|---|
| 28 tablets · Disp Pack | 28 | $294.99 | $240.01 |
Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.
Premphase is a brand-name hormone therapy that combines conjugated estrogens with medroxyprogesterone acetate in a 28-day tablet regimen for postmenopausal women with a uterus. If you're searching for a Premphase coupon, enter your ZIP above to see today's price at pharmacies near you — there's no FDA-approved generic version of this specific two-tablet kit, so the brand price is what you'll be comparing.
What Is Premphase and How Does It Work?
Premphase is a fixed-schedule hormone therapy kit made up of two different tablets. On days 1 through 14 of each cycle, you take a maroon tablet containing 0.625 mg of conjugated estrogens alone; on days 15 through 28, you switch to a light-blue tablet that adds 5 mg of medroxyprogesterone acetate (a progestin) to the same estrogen dose. Pairing estrogen with a progestin is standard practice for women who still have a uterus, since it protects the uterine lining from the overgrowth that estrogen alone can cause.
Premphase is FDA-approved to treat moderate-to-severe hot flashes and vulvar/vaginal atrophy associated with menopause, and to help prevent postmenopausal osteoporosis in women for whom other osteoporosis medicines aren't appropriate.
Manufacturer Savings Card vs. an Rx.com Cash Coupon
Pfizer, the manufacturer, has offered savings-card programs for its Premphase/Prempro hormone therapy line in the past; check Pfizer's official site for current terms, since manufacturer cards generally only work with commercial insurance and exclude Medicare and Medicaid patients. If you're uninsured, on Medicare, or your card gets declined at the register, an Rx.com cash coupon can still be used at the pharmacy — enter your ZIP above to compare today's price across pharmacies near you.
Is There a Generic for Premphase?
No. Premphase is a two-tablet kit with a specific day-by-day dosing schedule, and there is currently no FDA-approved, marketed generic that duplicates this exact kit. (A generic of conjugated estrogens alone, Premarin, does exist for other indications, but that is a different product with a different regimen.) Because there's no substitutable generic here, comparing cash prices across pharmacies is the main way to manage cost — prices for the brand can vary meaningfully from one pharmacy to the next.
Safety Information
Premphase carries an FDA boxed warning covering cardiovascular disorders, breast cancer, endometrial cancer, and probable dementia, based on findings from the Women's Health Initiative studies. In February 2026 the FDA approved removal of similar boxed-warning language from six other menopausal hormone therapy products (including Bijuva, Prometrium, Divigel, Cenestin, Enjuvia, and Estring); Premphase was not among those six, so its boxed warning currently remains in place. Hormone therapy isn't right for everyone — talk with your provider about your personal history and whether Premphase is appropriate for you.
This Premphase information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Premphase on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.