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Sodium Bicarbonate

Sodium Bicarbonate 650MG

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What is Sodium Bicarbonate?

Sodium bicarbonate, commonly known as baking soda, is a white crystalline compound with the formula NaHCO₃. It is used medicinally to treat acid indigestion and heartburn by neutralizing stomach acid. In pharmaceutical formulations, it also functions as an alkalinizing agent, helping to maintain the pH balance in the body.

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What is Sodium Bicarbonate ?

Sodium bicarbonate, commonly known as baking soda, is a white crystalline compound with the formula NaHCO₃. It is used medicinally to treat acid indigestion and heartburn by neutralizing stomach acid. In pharmaceutical formulations, it also functions as an alkalinizing agent, helping to maintain the pH balance in the body.
  • Rapid weight gain.
  • Stomach discomfort that gets worse or new stomach symptoms.
  • Headache that continues.
  • Shortness of breath, cold sweats, and bluish-colored skin.
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Severe stomach pain.
  • Swelling in your hands, ankles, or feet.
  • Make sure your doctor knows if you are pregnant or breastfeeding.
  • This medicine contains salt. Talk to your doctor before using this medicine if you are on a low-sodium (low-salt) diet.
  • Tell your doctor if your symptoms last for longer than two weeks.
  • Severe stomach pain.
  • Shortness of breath, cold sweats, and bluish-colored skin.
  • Stomach discomfort that gets worse or new stomach symptoms.
  • Swelling in your hands, ankles, or feet.
What is sodium bicarbonate used for?
Over the counter, sodium bicarbonate tablets and powder are labeled under the FDA's antacid monograph for relief of acid indigestion, heartburn, sour stomach, and the upset stomach that comes with those symptoms. Under a doctor's direction, oral sodium bicarbonate is also commonly used as a systemic alkalinizer to correct chronic metabolic acidosis in chronic kidney disease and renal tubular acidosis, and to make the urine less acidic, such as for preventing uric acid or cystine stones. A separate prescription injection is used in hospitals for metabolic acidosis, bicarbonate loss from severe diarrhea, certain poisonings, high potassium, and urinary alkalinization.
Is sodium bicarbonate the same as baking soda?
Chemically, yes. Sodium bicarbonate is the same compound as household baking soda. The difference is the product: drug-labeled sodium bicarbonate comes in measured tablets (commonly 325 mg, which is 5 grains, and 650 mg, which is 10 grains) or in powder with dosing directions, so you know exactly how much you are taking. A grocery box of baking soda is not a dosed medicine and should not be used for medical dosing unless your doctor specifically tells you how much to take.
Do you need a prescription for sodium bicarbonate tablets?
No. Oral sodium bicarbonate tablets and powder are available over the counter without a prescription. Sodium bicarbonate injection, on the other hand, is prescription and hospital-use only. Even though the tablets are OTC, prices vary between pharmacies, so it is worth comparing. And if you are taking it long-term on a doctor's instructions, ask whether having it written as a prescription lets the pharmacy run a discount coupon on it.
How much sodium bicarbonate is safe to take in a day?
For over-the-counter antacid use, follow the label. Adults under 60 should not take more than 24 tablets of the 650 mg (10 grain) strength in 24 hours, and adults 60 and older should not take more than 12 in 24 hours. Do not use it for more than two weeks for self-treatment without seeing a doctor, and do not give it to children under 12 unless a doctor directs it. If a doctor has you on sodium bicarbonate for kidney disease or urine alkalinization, follow their dose, not the OTC label.
What are the side effects of taking sodium bicarbonate for kidney disease?
The main concern is the sodium load, which can cause fluid retention, swelling in the feet or legs, and worsening of high blood pressure or heart failure. Taking too much bicarbonate can also cause metabolic alkalosis, low potassium, and low calcium, and taking it with a lot of milk or calcium can lead to milk-alkali syndrome. Milder effects include increased thirst, stomach cramps, and belching or gas. Anyone using it for kidney disease should be under a doctor's supervision with periodic lab monitoring, and should get emergency help for severe headache, slow breathing, weakness, irritability, blood in the urine, black or tarry stools, or vomit that looks like coffee grounds.
What medications should not be taken with sodium bicarbonate?
Sodium bicarbonate raises the pH in the stomach and the urine, so it can change how much of other drugs your body absorbs or gets rid of. Medicines affected include ketoconazole, itraconazole, iron supplements, tetracycline antibiotics, quinolone antibiotics, salicylates, lithium, and amphetamines. As a general rule, separate other medicines from sodium bicarbonate by at least 2 hours, and have your pharmacist review your full medication list before you start taking it regularly.
How much does Sodium Bicarbonate cost without insurance?
The price of Sodium Bicarbonate without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Sodium Bicarbonate?
Common side effects of Sodium Bicarbonate may include: Rapid weight gain., Stomach discomfort that gets worse or new stomach symptoms., Headache that continues., Shortness of breath, cold sweats, and bluish-colored skin., Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Sodium Bicarbonate?
Generic versions may be available for Sodium Bicarbonate. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Sodium Bicarbonate on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Sodium Bicarbonate?
The cheapest pharmacy for Sodium Bicarbonate depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Sodium Bicarbonate near you.

Sodium Bicarbonate Coupons & Prices

Sodium Bicarbonate 650MG

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Sodium Bicarbonate Tablet — prescription drug image
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Sodium Bicarbonate 650mg (60)
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Looking for a sodium bicarbonate coupon? Sodium bicarbonate is an alkali salt sold over the counter as plain, unbranded tablets (325 mg / 5 grain and 650 mg / 10 grain) and as powder, and it is also used under a doctor's direction to correct low bicarbonate levels or to make the urine less acidic. Because it is almost always an unbranded generic, there is no manufacturer copay card for it, but pharmacy cash prices still vary from store to store, and some pharmacies fill sodium bicarbonate tablets behind the counter or on a prescription where a discount coupon applies. Enter your ZIP code above to see today's price at pharmacies near you and print or text yourself a free Rx.com coupon before you go.

What is sodium bicarbonate and how does it work?

Sodium bicarbonate is the same compound as ordinary baking soda. It is a base, meaning it neutralizes acid. Swallowed as a tablet or dissolved powder, it reacts with stomach acid and raises the pH in the stomach, which is why it is covered by the FDA's over-the-counter antacid monograph for relief of acid indigestion, heartburn, sour stomach, and the upset stomach that goes with those symptoms. Some of the bicarbonate is absorbed into the blood, so unlike antacids that stay in the gut, sodium bicarbonate also raises the pH of the blood and the urine. That is why it is classed as both an antacid and a systemic and urinary alkalinizing agent.

That whole-body effect is the reason doctors sometimes direct patients to take oral sodium bicarbonate for reasons that go beyond the OTC label, including correcting chronic metabolic acidosis in chronic kidney disease and renal tubular acidosis, and alkalinizing the urine to help prevent uric acid or cystine stones. Those uses are clinical-practice uses directed by a clinician rather than FDA-monograph OTC uses, and the dose and monitoring are different from heartburn dosing, so do not start them on your own. A separate prescription sodium bicarbonate injection exists for hospital use in metabolic acidosis, large bicarbonate losses from severe diarrhea, certain poisonings such as tricyclic antidepressant overdose and salicylate poisoning, high potassium, and urinary alkalinization. This page is general information, not medical advice.

How to save on sodium bicarbonate with an Rx.com coupon

Sodium bicarbonate is sold mainly as an unbranded generic, so there is no brand-name manufacturer savings card to chase. What does change is the pharmacy. Cash prices for the same 325 mg or 650 mg bottle can differ noticeably between a chain drugstore, a grocery pharmacy, and a warehouse pharmacy in the same town. Enter your ZIP above to compare what pharmacies near you are charging today.

A few practical notes for an over-the-counter product like this one:

  • Some OTC items ring up cheaper when your prescriber writes them as a prescription and the pharmacy runs a discount coupon on it, so it is worth asking, especially if you are taking sodium bicarbonate long-term for a kidney or urine-alkalinizing reason.
  • The Rx.com coupon is free, has no membership fee, and does not use your insurance. Show it at the counter and the pharmacist applies the discounted price.
  • If your plan does cover it, compare your copay to the coupon price and use whichever is lower. You cannot combine the two on one fill.
  • Bicarbonate bought as a plain grocery-aisle baking soda box is not a substitute for a labeled, dosed drug product, and it should not be used for medical dosing unless your doctor specifically tells you how.

Sodium bicarbonate vs. other options

For plain heartburn and acid indigestion, sodium bicarbonate is a fast, short-acting antacid, but it comes with a large sodium load and a systemic effect that other choices do not have. Calcium carbonate is another over-the-counter antacid that works locally in the stomach without the sodium. For symptoms that keep coming back, acid reducers work differently and last longer: famotidine is an H2 blocker, while omeprazole and pantoprazole are proton pump inhibitors that cut acid production for a longer stretch. (Zegerid is a marketed combination of omeprazole with sodium bicarbonate, where the bicarbonate is there to protect the omeprazole from stomach acid.)

When sodium bicarbonate is used to alkalinize the urine, for example to help prevent uric acid stones, potassium citrate is the alternative a doctor may prefer, since it raises urine pH without adding sodium. Which one is right depends on your kidney function, your blood potassium, and your blood pressure, so that is a conversation for your clinician, not a swap to make on your own.

Safety, side effects, and drug interactions

Sodium bicarbonate has no boxed warning, but it is not a harmless product. Every dose delivers a meaningful amount of sodium. Use it with caution, or avoid it, if you are on a sodium-restricted diet or have heart failure, high blood pressure, swelling (edema), cirrhosis, or kidney disease. Taking too much, or taking it for too long, can push the body's chemistry too far the other way and cause metabolic alkalosis, low potassium, low calcium, and fluid retention. Combining it heavily with milk or calcium supplements can cause milk-alkali syndrome. The more common, milder effects are increased thirst, stomach cramps, and belching or gas.

Follow the label limits: for adults under 60, no more than 24 tablets of the 650 mg strength in 24 hours; for age 60 and older, no more than 12. Do not self-treat for more than two weeks without seeing a doctor, and do not give it to children under 12 unless a doctor directs it. Because it raises stomach and urine pH, sodium bicarbonate can change how much of other medicines your body absorbs or clears, including ketoconazole, itraconazole, iron, tetracyclines, quinolone antibiotics, salicylates, lithium, and amphetamines, so separate other medicines from it by at least 2 hours and ask your pharmacist to check your full list. Get emergency help for severe headache, vomit that looks like coffee grounds, black or tarry stools, blood in the urine, slow breathing, weakness, irritability, or swelling of the feet or legs. This is general information and not a substitute for advice from your own provider.

Sources & accuracy

This Sodium Bicarbonate information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Sodium Bicarbonate on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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