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Sumatriptan Succinate

SUMAtriptan Succinate 100MG

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What is Sumatriptan Succinate?

Imitrex treats migraines and cluster headaches. Sumatriptan succinate is the generic version of Imitrex. The Imitrex cost of 9 tablets, 100mg is about $667. However, you can significantly reduce your Imitrex cost by using our free Rx.com coupon card when picking up your medication at your local pharmacy.

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What is Sumatriptan Succinate ?

Imitrex treats migraines and cluster headaches. Sumatriptan succinate is the generic version of Imitrex. The Imitrex cost of 9 tablets, 100mg is about $667. However, you can significantly reduce your Imitrex cost by using our free Rx.com coupon card when picking up your medication at your local pharmacy.
  • Fast, pounding, or uneven heartbeat, dizziness
  • Vision loss or vision changes that are not part of a usual migraine
  • Severe stomach pain, bloody diarrhea, nausea, or vomiting
  • Seizure
  • Chest pain, especially if it spreads to your arms, jaw, back, or neck, trouble breathing, unusual sweating, faintness
  • Tightness or discomfort in your chest, neck, or jaw
  • Anxiety, restlessness, fever, sweating, muscle spasms, twitching, diarrhea, seeing or hearing things that are not there
  • Numbness, tingling, cramps, unexplained pain in your hands, arms, legs, or feet, color changes in your fingers or toes
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Sudden severe headache (other than the one being treated)
  • Tell your doctor if you are pregnant, or if you have kidney disease, liver disease, diabetes, high blood pressure, high cholesterol, or a history of seizures. Tell your doctor if you have a family history of heart disease, a history of blood circulation problems (such as peripheral vascular disease), or if you smoke.
  • Do not breastfeed for at least 12 hours after you take this medicine.
  • This medicine should be used only for classic or common migraine headaches. It will not work for any other kind of headache or pain.
  • This medicine may cause the following problems:Higher risk for abnormal heart rhythm, heart attack, or strokeTightness or discomfort in your chest, neck, or jawSpasms in the blood vessels, including Raynaud syndromeSerotonin syndrome (more likely if used with medicine to treat depression)High blood pressure
  • Your headaches may become worse if you use this medicine for 10 or more days per month. Keep a journal and write down how often your headaches occur and how often you take this medicine.
  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
  • Call your doctor if your symptoms do not improve or if they get worse.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Tightness or discomfort in your chest, neck, or jaw
  • Vision loss or vision changes that are not part of a usual migraine
What is sumatriptan succinate used for?
Sumatriptan succinate is FDA-approved for the acute treatment of migraine attacks (with or without aura) in adults. It relieves a migraine that has already started, along with symptoms like nausea and sensitivity to light and sound. The injectable form is also approved for acute cluster headache. It is not used to prevent migraines.
How long does it take for sumatriptan to work on a migraine?
It varies by form. The subcutaneous injection usually works fastest, often within about 10 to 15 minutes, while tablets and the nasal spray typically start working within roughly 30 minutes to 2 hours. Taking it early in the attack tends to work best. Ask your prescriber what to expect for the form you were given.
Can you take a second dose of sumatriptan if the first doesn't work?
If a first dose does not relieve your migraine at all, a second dose usually will not help either, so check your product's instructions and your prescriber's guidance before repeating. If the migraine improved and then came back, a second dose may be an option after the minimum time stated on your label, without going over the maximum daily amount. Do not exceed the dosing limits your prescriber sets, and do not use it too many days per week to avoid rebound headaches.
What are the most common side effects of sumatriptan?
Common side effects include tingling, warmth or flushing, dizziness, drowsiness, and a feeling of tightness or pressure in the chest, throat, jaw, or neck. The injectable form can also cause reactions at the injection site. Contact your provider right away if you have chest pain, a severe or unusual headache, or signs of an allergic reaction.
Who should not take sumatriptan?
Sumatriptan should be avoided by people with heart disease such as ischemic coronary artery disease or coronary vasospasm, a history of heart attack, certain heart-rhythm disorders, uncontrolled high blood pressure, hemiplegic or basilar migraine, or severe liver problems. Do not use it within 24 hours of an ergotamine or another triptan, or within 2 weeks of an MAO-A inhibitor. Always confirm with your doctor or pharmacist that it is safe with your health history and other medicines.
How much does Sumatriptan Succinate cost without insurance?
The price of Sumatriptan Succinate without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Sumatriptan Succinate?
Common side effects of Sumatriptan Succinate may include: Fast, pounding, or uneven heartbeat, dizziness, Vision loss or vision changes that are not part of a usual migraine, Severe stomach pain, bloody diarrhea, nausea, or vomiting, Seizure, Chest pain, especially if it spreads to your arms, jaw, back, or neck, trouble breathing, unusual sweating, faintness. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Sumatriptan Succinate?
Generic versions may be available for Sumatriptan Succinate. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Sumatriptan Succinate on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Sumatriptan Succinate?
The cheapest pharmacy for Sumatriptan Succinate depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Sumatriptan Succinate near you.

Sumatriptan Succinate Coupons & Prices

SUMAtriptan Succinate 100MG

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Sumatriptan Succinate Tablet — prescription drug image
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Looking for a sumatriptan succinate coupon? Sumatriptan succinate is the low-cost generic version of Imitrex, a triptan used for the acute treatment of migraine attacks in adults. Because it is available as a generic, cash prices are already low, but the exact price can vary widely from one pharmacy to the next. Rx.com compares prices across more than 60,000 pharmacies so you can find today's best price near you. Enter your ZIP above to see the current price and print or show your free coupon at the pharmacy counter.

What is sumatriptan succinate and how does it work?

Sumatriptan succinate is a triptan, a class of medicines known as selective serotonin (5-HT1B/1D) receptor agonists. It is FDA-approved for the acute treatment of migraine (with or without aura) in adults. The injectable form is also approved for acute cluster headache. It works during an attack by narrowing blood vessels in the brain and blocking pain signals, which helps relieve the headache along with related symptoms such as nausea and sensitivity to light and sound.

Sumatriptan treats a migraine that has already started. It is not a preventive medicine and will not stop future migraines from happening. It comes in several forms, including tablets, a nasal spray, and a subcutaneous injection. Sumatriptan is also sold combined with naproxen as sumatriptan/naproxen (brand Treximet).

Sumatriptan succinate cost and savings without insurance

Sumatriptan succinate is a generic, so it is generally one of the more affordable migraine options, but prices are not the same everywhere. The cash price for the same strength and quantity can differ significantly between nearby pharmacies, which is exactly why comparing matters. Rx.com checks live prices across more than 60,000 pharmacies to help you find the lowest price in your area.

Our discount coupon is free to use and does not require insurance. If you are paying cash, or if your plan does not cover this medication well, a coupon price may be lower than your copay, so it is worth comparing both. Enter your ZIP above to see today's price for the form and strength your prescriber ordered, then show the coupon at checkout.

Comparing sumatriptan to other triptans and the brand version

Sumatriptan is the generic equivalent of the brand Imitrex. The generic and brand contain the same active ingredient; the generic simply costs less. You may also see sumatriptan listed under other brand names such as Tosymra, Zembrace SymTouch, Onzetra Xsail, and Alsuma. If you were prescribed the generic, see sumatriptan.

Sumatriptan is one of several triptans. Others that your prescriber may consider include rizatriptan (Maxalt), zolmitriptan, eletriptan, and naratriptan. These medicines work in similar ways but differ in how fast they act and how long they last, so people sometimes respond better to one than another. Which triptan is right for you is a decision to make with your provider.

Safety, side effects, and who should not take it

Single-ingredient sumatriptan does not carry a boxed warning. (The Treximet combination does carry naproxen's NSAID boxed warnings for cardiovascular and stomach-bleeding risks.) The most common side effects include tingling, warmth or flushing, dizziness, drowsiness, and a feeling of tightness or pressure in the chest, throat, jaw, or neck. The subcutaneous injection can also cause reactions at the injection site.

Sumatriptan is not for everyone. It should not be used by people with ischemic coronary artery disease, coronary vasospasm (including Prinzmetal angina), a history of heart attack, certain heart-rhythm problems from accessory conduction pathways (such as Wolff-Parkinson-White, for the injection), uncontrolled high blood pressure, hemiplegic or basilar migraine, or severe liver problems. Do not take it within 24 hours of an ergotamine or other 5-HT1 agonist, and not within 2 weeks of an MAO-A inhibitor. There is also a risk of serotonin syndrome (especially with SSRIs or SNRIs) and of medication-overuse (rebound) headache if it is used too often. This is general information and not medical advice, so review your full history and current medicines with your doctor or pharmacist before starting sumatriptan.

Sources & accuracy

This Sumatriptan Succinate information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Sumatriptan Succinate on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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