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Zoledronic Acid Bottle — prescription drug image

Zoledronic Acid

Zoledronic Acid 100ML of 4MG/100ML

Prescriptions & Refills
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What is Zoledronic Acid?

Reclast is a bisphosphonate medication that is prescribed to patients diagnosed with osteoporosis or Paget's disease to treat their condition. Zoledronic acid is the generic version of Reclast. The average Reclast price is about $1,140 for a supply of 100 milliliters, 5 mg/100 mL intravenous solution. However, you can use our free Rx.com coupon card to save significantly on Reclast prices at a participating pharmacy near you.

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What is Zoledronic Acid ?

Reclast is a bisphosphonate medication that is prescribed to patients diagnosed with osteoporosis or Paget's disease to treat their condition. Zoledronic acid is the generic version of Reclast. The average Reclast price is about $1,140 for a supply of 100 milliliters, 5 mg/100 mL intravenous solution. However, you can use our free Rx.com coupon card to save significantly on Reclast prices at a participating pharmacy near you.
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest pain, trouble breathing, fast or uneven heartbeat
  • Decrease in how much or how often you urinate, blood in the urine, lower back or side pain, burning or painful urination
  • Muscle spasm or twitching, or numbness or tingling in your fingers, feet, or around your mouth
  • Severe muscle, bone, or joint pain
  • Unusual pain in your thigh, groin, or hip
  • Pain, swelling, or numbness in the mouth or jaw, loose teeth or other teeth problems
  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Tell your doctor if you are breastfeeding, or if you have kidney disease, anemia, aspirin-sensitive asthma, bleeding problems, cancer, congestive heart failure, low blood calcium levels, stomach absorption problems, mineral imbalance, dental problems or gum disease. Also tell your doctor if you had surgery on your bowel or parathyroid or thyroid gland.
  • This medicine may cause the following problems:Jaw or teeth problemsSevere bone, joint, or muscle painIncreased risk of thigh bone fractureLow calcium levels in your blood
  • You must have regular dental exams while you are being treated with this medicine. Tell your dentist or oral surgeon that you are using this medicine.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Severe muscle, bone, or joint pain
  • Unusual pain in your thigh, groin, or hip
What is zoledronic acid used for?
Zoledronic acid is a bisphosphonate used to treat and prevent osteoporosis in postmenopausal women, to increase bone mass in men with osteoporosis, to treat and prevent steroid-induced osteoporosis, and to treat Paget's disease of bone (all as Reclast). As Zometa, it is used in cancer care for high blood calcium caused by cancer and for bone problems from solid-tumor metastases and multiple myeloma. It works by slowing the cells that break down bone.
How often is a zoledronic acid (Reclast) infusion given?
For osteoporosis treatment, Reclast (5 mg) is typically given as a single IV infusion once a year. For preventing postmenopausal osteoporosis, it may be given once every two years. Your provider decides the exact schedule based on your condition, and the infusion is always given by a healthcare professional.
What are the most common side effects of a zoledronic acid infusion?
The most common side effect is an acute-phase reaction: flu-like symptoms such as fever, chills, and bone, muscle, or joint pain that appear in the days after the infusion and usually go away on their own. More serious but less common risks include kidney problems, low blood calcium, jaw-bone problems (osteonecrosis of the jaw), and rare thigh-bone fractures. Contact your provider about any symptoms that concern you.
What is the difference between Reclast and Zometa?
Reclast and Zometa are two brand names for the same drug, zoledronic acid, used at different doses for different purposes. Reclast (5 mg) is used for osteoporosis and Paget's disease of bone. Zometa (4 mg) is used in cancer care for high blood calcium from cancer and for bone metastases and multiple myeloma. The identical active ingredient should never be given as both products at the same time.
Why do I need to drink water and take calcium and vitamin D with zoledronic acid?
Staying well hydrated before and after the infusion helps protect your kidneys, since zoledronic acid can affect kidney function, especially if you are dehydrated. Taking calcium and vitamin D helps prevent your blood calcium from dropping too low, a known risk of the drug. Your provider will usually check and correct any calcium or vitamin D deficiency before treatment and advise you on supplements.
How much does Zoledronic Acid cost without insurance?
The price of Zoledronic Acid without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Zoledronic Acid?
Common side effects of Zoledronic Acid may include: Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Chest pain, trouble breathing, fast or uneven heartbeat, Decrease in how much or how often you urinate, blood in the urine, lower back or side pain, burning or painful urination, Muscle spasm or twitching, or numbness or tingling in your fingers, feet, or around your mouth, Severe muscle, bone, or joint pain. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Zoledronic Acid?
Generic versions may be available for Zoledronic Acid. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Zoledronic Acid on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Zoledronic Acid?
The cheapest pharmacy for Zoledronic Acid depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Zoledronic Acid near you.

Zoledronic Acid Coupons & Prices

Zoledronic Acid 100ML of 4MG/100ML

Prescriptions & Refills
Licensed US providers · Online visit in minutes
Zoledronic Acid Bottle — prescription drug image
Prescription
Zoledronic Acid 100ml of 4mg/100ml (1)
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Looking for a zoledronic acid coupon? Zoledronic acid is the generic version of the branded infusions Reclast and Zometa, and because it is available as an FDA-approved generic it is already far less expensive than brand-name pricing. The catch is that the cash price for the infusion drug can vary widely from one pharmacy or infusion supplier to the next, so comparing before you fill matters. Rx.com compares zoledronic acid prices across more than 60,000 pharmacies so you can find the lowest cash price near you. Enter your ZIP above to see today's price and print a free coupon.

What is zoledronic acid and how does it work?

Zoledronic acid is a bisphosphonate, a class of medicines that slow the natural breakdown of bone. It works by blocking the activity of osteoclasts, the cells that dissolve and resorb bone, which helps preserve bone mass and strength. It is sold under the brand names Reclast, Zometa, and Aclasta, all of which contain the same active ingredient.

Zoledronic acid is given only as an intravenous (IV) infusion by a healthcare provider. There is no pill or oral form. Reclast (5 mg, usually given once yearly or every two years) is used to treat and prevent postmenopausal osteoporosis, to increase bone mass in men with osteoporosis, to treat and prevent osteoporosis caused by long-term glucocorticoid (steroid) use, and to treat Paget's disease of bone in men and women. Zometa (4 mg) is used in cancer care for hypercalcemia of malignancy and for bone metastases from solid tumors such as breast, prostate, and lung cancer as well as multiple myeloma bone lesions, given alongside appropriate cancer therapy.

Zoledronic acid cost and coupon savings

Because zoledronic acid is available as a generic, it typically costs much less than the brand-name Reclast or Zometa. Even so, the cash price is not the same everywhere. Different pharmacies and infusion suppliers set their own prices, and the gap between the highest and lowest price for the same drug can be surprisingly large. That is exactly why comparing pays off.

If you do not have insurance, or your plan does not cover the infusion, a free Rx.com coupon can lower the cash price you pay. There is no manufacturer savings card for zoledronic acid, but our discount works at the pharmacy counter with no membership or sign-up. Enter your ZIP above to see today's price at pharmacies near you and print or text yourself the coupon. Keep in mind that a provider's separate charge for administering the infusion is billed on top of the drug itself.

Reclast, Zometa, and other bone-strengthening options

Reclast and Zometa are two branded forms of the very same drug, zoledronic acid, prescribed at different doses for different conditions. Because a substitutable generic exists, your provider or pharmacy can usually supply generic zoledronic acid in place of either brand. The same active ingredient should never be given as both Reclast and Zometa at the same time.

If an IV infusion is not the right fit, there are oral bisphosphonate alternatives for osteoporosis, including alendronate, risedronate, and ibandronate. A different, non-bisphosphonate injectable option is denosumab, sold as Prolia. Only your provider can decide which medicine and schedule are right for you, but you can compare cash prices on any of them with Rx.com.

Safety and side effects to know

Zoledronic acid has no boxed warning, but it does carry important precautions. It should not be used by people with significant kidney impairment (for Reclast, a creatinine clearance below 35 mL/min or acute kidney injury), by people with low blood calcium (hypocalcemia), or during pregnancy. Serious risks include acute kidney injury, severely low calcium, osteonecrosis of the jaw (a rare jaw-bone problem, which is why dental work should be completed beforehand), and rare atypical thigh-bone fractures. Your provider will check your kidney function and correct any calcium or vitamin D deficiency before treatment.

The most common side effect is an acute-phase reaction, meaning flu-like symptoms such as fever, chills, and bone, muscle, or joint pain in the first few days after the infusion; these usually ease on their own. Staying well hydrated, taking calcium and vitamin D as directed, and telling your provider about diuretics or other kidney-affecting medicines all help lower the risks. This is general information, not medical advice; talk with your provider or pharmacist about your specific situation.

Sources & accuracy

This Zoledronic Acid information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Zoledronic Acid on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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