Quad Mix: 4 ED Medications in One Dose

What is Quad Mix?

Quad Mix is an erectile dysfunction treatment built on a simple idea: instead of relying on a single active ingredient, combine four that work in different ways.

You may also see it called Quad Rx, Quad ED drops, Quad liquid, Quad for men or 4-in-1 ED medicine. They all describe the same idea: several ED medications combined in one fast-absorbing sublingual dose instead of a single pill.

Rx.com's Quad Rx delivers that 4-in-1 formula as a compounded prescription liquid that dissolves under your tongue. Three of its ingredients are the PDE5 inhibitors behind Viagra, Cialis and Levitra, which improve blood flow. The fourth, apomorphine, works in the brain on the pathways involved in arousal.

Because it is prescription only, every order includes an online health evaluation reviewed by an independent U.S.-licensed provider. If treatment is clinically appropriate, a U.S.-licensed pharmacy fills the prescription and ships it to you.

Why settle for an incomplete formula?

A single ED pill covers one window. Quad Rx layers short- and long-acting ingredients, so the formula covers more of the weekend than any one of them alone.

MEDVi Quad vs. Quad Rx

Both are compounded 4-in-1 sublingual ED treatments sold online with the name "Quad", so they are easy to confuse. They are separate products from separate companies, and their formulas are not the same.

The key difference is the fourth ingredient. Quad Rx uses vardenafil, the prescription PDE5 inhibitor in Levitra, where MEDVi's formula uses L-citrulline, an amino acid also sold as a supplement. Quad Rx also includes free express shipping, the same price on every renewal, and you are only billed if a prescription is approved.

*MEDVi details are from MEDVi's published materials as of September 2026; MEDVi has changed its Quad formula more than once in 2026, so check its site for the current version. MEDVi is a trademark of its owner. Rx.com is not affiliated with MEDVi.