TB-500: Benefits, Side Effects and How to Buy It Legally
Most TB-500 for sale online is labeled "research use only" and is not made for people. Rx.com is launching prescription TB-500, compounded by a licensed U.S. 503A pharmacy under the FDA's October 2026 interim peptide policy and prescribed by U.S.-licensed providers. Join the waitlist to be first when ordering opens.
- Real prescription TB-500, not "research use only"
- Compounded by a licensed U.S. 503A pharmacy
- Online visit with a U.S.-licensed provider
- Shipped to your door at launch
Coming soon
Compounded TB-500
Prescription compounded peptide
A thymosin beta-4 fragment studied for tissue repair and flexibility; often paired with BPC-157.
Available now
Compounded BPC-157
Prescription compounded peptide
The most-discussed recovery peptide, studied for tendon, ligament, muscle and gut-lining repair.
Coming soon
Compounded KPV
Prescription compounded peptide
A tiny anti-inflammatory peptide studied for the gut lining, skin and wound healing.
Want the science first? Read the full guide below
Get prescription TB-500 first: join the waitlist
Ordering opens soon. We'll email you the price and launch day, and waitlist members hear first.
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What is TB-500?
A thymosin beta-4 fragment for tissue repair
TB-500 is a synthetic fragment of thymosin beta-4, a protein the body uses to move and organize cells during repair. In lab and animal research it has been studied for wound healing, muscle and tendon repair and flexibility.
There are no published human safety studies of TB-500, which the FDA's reviewers flagged. It is also banned in competitive sports. It is best known as the partner to BPC-157 in the "Wolverine stack."
Where to buy TB-500
Where to buy TB-500 legally in 2026
Search "buy TB-500" or "TB-500 for sale" and most results are research-chemical websites. Their vials are labeled "research use only" or "not for human consumption," they are not made under pharmacy standards, they can be underdosed, contaminated or mislabeled, and the FDA's 2026 policy does not cover them.
Since October 28, 2026 there is a legal route. The FDA said it will not take enforcement action against licensed 503A compounding pharmacies and physicians that prepare TB-500 for an individual patient with a prescription, as long as they meet requirements for ingredient quality, manufacturing, labeling and safety reporting. That means the legitimate way to get TB-500 online is a prescription from a licensed provider, filled by a licensed pharmacy.
That is exactly what Rx.com is building: an online visit with a U.S.-licensed provider, then TB-500 compounded for you by a licensed U.S. 503A pharmacy and shipped to your door. TB-500, the BPC-157 partner in the "Wolverine stack", is studied for muscle, tendon and wound repair and flexibility. It is not FDA approved, and your provider will tell you honestly whether it fits your goals. Many people also ask about pairing it with BPC-157, and you can compare all six on the buy peptides online page.
TB-500 benefits: what it is studied for
RecoveryMuscle and tendon repair
Studied in animals for healing after muscle and tendon injury.
MobilityFlexibility
Discussed for joint comfort and range of motion. Human evidence is lacking.
Wound healingSkin and wound repair
Thymosin beta-4 has been studied for wound and skin repair.
Compounded TB-500 vs. research peptides
| Rx.com (coming soon) | Research-use-only sellers | |
|---|---|---|
| Prescription and medical review | Yes. A U.S.-licensed provider reviews your health history and prescribes only if it is right for you. | No. Anyone can order, with no prescription and no medical review. |
| Who makes it | A licensed, state-inspected 503A compounding pharmacy prepares it for you under your prescription. | Unknown. The vials are labeled "research use only" or "not for human use." |
| Quality standards | It is made to pharmacy compounding standards, and the pharmacy is licensed and inspected by its state board of pharmacy. | None. Research chemicals do not have to meet any standard for people. |
| Legal status | It is covered by the FDA's October 2026 interim policy for compounded peptides. | It is outside the FDA policy and is not sold for people to use. |
Compounded peptides are not FDA approved. Research-use-only peptides sold online are not made or tested for people. A prescription from a licensed provider, filled by a licensed and state-inspected 503A pharmacy, is the only route the FDA's policy covers.
Prescription only
What changed in October 2026
On October 28, 2026 the FDA and HHS published an interim policy for six peptides: BPC-157, TB-500, KPV, MOTS-c, Semax and Epitalon. The FDA said it will not take enforcement action against licensed 503A compounding pharmacies and physicians that prepare them for individual patients with a prescription, as long as they meet requirements for ingredient quality, manufacturing, labeling and safety reporting.
This is not FDA approval. The peptides have not been through the FDA's review for safety or effectiveness, the policy is temporary and can change, and some states may set their own rules. Rx.com is setting up access through U.S.-licensed providers and a licensed pharmacy and will open online visits when it is ready.
- Oct 28, 2026
Policy published
The FDA's interim policy lets licensed 503A pharmacies compound six peptides for individual patients.
- Now
Getting ready
Rx.com is setting up licensed providers and a licensed U.S. pharmacy. Join the list to hear first.
- At launch
Online visits open
Complete an intake, a provider reviews it, and your prescription ships if it is right for you.
TB-500 price: what will it cost?
Rx.com will post TB-500 pricing on this page at launch, before you pay anything, and you will be billed only if a provider prescribes it. Prescription compounded peptides usually cost more than research-chemical vials because the price covers a licensed provider, a licensed pharmacy that compounds and tests to pharmacy standards, and shipping.
Join the waitlist above and we will email you the price and the day ordering opens. TB-500 injections and other forms will be listed at launch if the pharmacy offers them; your provider chooses the form that is right for you.
How it will work
U.S.-licensed providers
Online health intake
A short, confidential questionnaire about your health, goals and medications. No appointment, no waiting room.
Provider review
A U.S.-licensed provider reviews your answers and prescribes only if treatment is right for you.
Delivered to your door
A licensed U.S. pharmacy fills your prescription and ships it to you.
FAQs
Where can I buy TB-500 legally?
Can I buy TB-500 online?
Is TB-500 legal?
Is TB-500 for sale online safe?
How much does TB-500 cost?
What are the side effects of TB-500?
Is TB-500 FDA approved?
Do I need a prescription?
Is it legal in my state?
Important safety information
TB-500 is not FDA approved. Its safety and effectiveness have not been established in large human trials, and the FDA's own reviewers noted limited human safety data for the peptides covered by the 2026 interim policy. Side effects and long-term risks are not fully known.
Do not use TB-500 if you are pregnant, breastfeeding or trying to conceive, or if you have or have had cancer, unless your provider says otherwise. Tell your provider about every medication and supplement you take and any health conditions. Never use products labeled "research use only" or "not for human consumption."
TB-500 is prohibited by the World Anti-Doping Agency and most sports organizations. Tested athletes should not use it.
Coming soon to Rx.com
A confidential online visit with a U.S.-licensed provider, and treatment shipped to your door if it is right for you. See all prescription peptides.
Join the Waitlist Read the full guidePrescription required. Medications are prescribed only when clinically appropriate after an evaluation by a licensed independent provider. Compounded medications are prepared by a licensed pharmacy for an individual patient and are not FDA-approved; the FDA has not evaluated them for safety, effectiveness or quality. Individual results vary.
Peptide status: BPC-157, TB-500, KPV, MOTS-c, Semax and Epitalon are not approved by the FDA. Under the FDA's October 2026 interim enforcement-discretion policy, licensed 503A pharmacies may compound them for individual patients with a valid prescription. BPC-157, MOTS-c and Epitalon are available through Rx.com with a prescription; TB-500, KPV and Semax are not yet.
Medical services: All clinical evaluations, treatment planning and prescribing decisions are made by licensed independent medical providers. Rx.com provides the technology platform, does not employ healthcare providers and does not practice medicine. This page is for information and is not a substitute for professional medical advice.
TB-500 guide: research, safety and FDA status
TB-500 is a synthetic peptide based on a region of a naturally occurring protein called Thymosin Beta-4, which is found in nearly every cell in the body and plays a role in cell movement and repair. TB-500 is widely discussed in athletic and veterinary recovery circles for tissue healing and flexibility. Like the other peptides here, TB-500 is investigational — it is not FDA approved and is not sold or prescribed through Rx.com.
How is TB-500 thought to work?
In preclinical research, TB-500 is described as promoting cell migration and new blood-vessel growth, both of which are central to healing damaged tissue. It is also studied for effects on flexibility and inflammation. As with the other peptides on this page, the strongest evidence is from laboratory and animal models, so human benefits are not established.
TB-500 side effects
There are no published human studies of TB-500, so no one can give a reliable list or rate of side effects. Reports and theoretical concerns include:
- Pain, redness or swelling at the injection site
- Infection if a product is not sterile
- Allergic or immune reactions such as rash or flu-like symptoms
- Headache or tiredness
TB-500 is a fragment of thymosin beta-4, which helps grow new blood vessels and is found at high levels in some cancers. Whether the fragment carries the same risk is unknown, so people with active cancer or a history of cancer, and anyone pregnant or breastfeeding, are advised to avoid it. Call your provider about fever, spreading redness at the injection site or any reaction that worries you.
How TB-500 is taken
Prescription TB-500 is compounded as an injection given under the skin (subcutaneous). Unlike BPC-157 it is not usually injected near the injury, because it is thought to act throughout the body. It is typically prescribed for a set number of weeks.
Your provider chooses the form, dose and schedule, and the pharmacy label on your prescription lists them. Do not copy doses from forums or research-chemical sellers.
TB-500 dosage
There is no FDA-approved or trial-tested dose of TB-500. Below is what providers commonly prescribe.
- Common prescribed range: about 2 to 2.5 mg injected under the skin twice a week for the first 4 to 6 weeks, then about 2 mg once a week. Some protocols start as high as 5 mg twice a week.
- In human studies: none. FDA's July 2026 review found no human studies of TB-500 by any route; its only drug-level data come from horses. Trials of full-length thymosin beta-4 (an IV infusion and an eye drop) used a different molecule and do not apply to TB-500.
- With BPC-157: in the Wolverine stack, TB-500 is usually prescribed on that same twice-weekly then weekly schedule alongside daily BPC-157.
Your provider sets your dose, schedule and course length based on your health, goals and other medicines. Do not change your dose on your own.
What human studies have found
The evidence for TB-500 comes from studies of the full thymosin beta-4 protein in animals and cells, where it helped wounds close, reduced scarring and supported muscle, heart and eye repair. Studies of the TB-500 fragment itself are mostly anti-doping lab work showing how to detect it, because it has been misused in horse racing and sport.
Recent sports-medicine reviews note there are no clinical trials of TB-500 for injuries or athletic performance. It is banned by the World Anti-Doping Agency, so tested athletes should not use it.
TB-500 and BPC-157: the "Wolverine stack"
TB-500 is most often discussed with BPC-157. The theory is that the two work in complementary ways, but the combination has never been studied in people. See our Wolverine stack guide and BPC-157 vs. TB-500 comparison.
Frequently asked questions
Why is TB-500 part of the "Wolverine stack"?
What is TB-500 used for?
Is TB-500 the same as BPC-157?
Is TB-500 allowed in sports?
References
- Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance. Sports Med, 2026.
- Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians. Am J Sports Med, 2026.
- Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500. Drug Test Anal, 2012.
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions. J Am Acad Orthop Surg Glob Res Rev, 2026.
- FDA Pharmacy Compounding Advisory Committee briefing document: TB-500, July 2026.
