Wolverine Stack: BPC-157 + TB-500, by Prescription
The "Wolverine stack" is the nickname for taking two recovery peptides, BPC-157 and TB-500, together. Most of what is sold online is labeled "research use only." Rx.com offers both by prescription, compounded by a licensed U.S. 503A pharmacy.
- BPC-157 + TB-500, prescribed by a U.S.-licensed provider
- Compounded by a licensed U.S. 503A pharmacy, not "research use only"
- Your provider sets the dose and schedule
Available now
Compounded BPC-157
Prescription compounded peptide
The most-discussed recovery peptide, studied for tendon, ligament, muscle and gut-lining repair.
Coming soon
Compounded TB-500
Prescription compounded peptide
A thymosin beta-4 fragment studied for tissue repair and flexibility; often paired with BPC-157.
BPC-157 can be ordered now; TB-500 is coming soon. Join the waitlist for the Wolverine stack
Wolverine peptide stack
What is the Wolverine stack?
The Wolverine stack (also called the Wolverine peptide or Wolverine peptide stack) is BPC-157 and TB-500 used together. The name comes from the comic-book character who heals fast, because both peptides are studied for tissue repair.
People use the stack for tendon, ligament and muscle injuries, slow-healing joints and recovery from training. The idea is that the two peptides work in different ways, so together they may cover more of the repair process than either one alone.
That idea has not been tested. No published study has given BPC-157 and TB-500 together to people, so the stack is a theory based on animal and lab work, not a proven treatment.
BPC-157 and TB-500: what each one does
BPC-157
A 15-amino-acid fragment of a protein found in stomach juice. In animal studies it sped up healing of tendons, ligaments, muscle and the gut lining, largely by helping new blood vessels grow into injured tissue. It works mostly where it is given.
Buy BPC-157 online →
TB-500
A synthetic piece of thymosin beta-4, a protein the body uses to move cells into a wound. In lab and animal work, thymosin beta-4 helped cells migrate, calmed inflammation and limited scarring. It is thought to act more widely through the body.
TB-500: benefits, side effects and status →What the research shows
BPC-157: dozens of rat and mouse studies show faster healing of tendons, ligaments, muscle and gut tissue. Human data is limited to a few small reports: a knee-pain study where most patients reported relief after an injection into the joint, and a 2025 pilot that gave BPC-157 by IV to two adults with no measured harm. There are no large controlled trials.
TB-500: there are no published human studies of TB-500 itself. Its parent protein, thymosin beta-4, has been tested in people for eye and skin wounds, but that is a different molecule. Sports-medicine reviews in 2026 conclude the evidence is preclinical.
Together: no study has tested the combination in people or animals. Anyone who tells you the stack is proven to heal injuries faster is going beyond the evidence.
Wolverine stack dosage
There is no approved or studied dose for the Wolverine stack, and no study has given BPC-157 and TB-500 together. The ranges below are what providers commonly prescribe, drawn from FDA's July 2026 review of these peptides and published reviews, not from trials.
| Peptide | Typical prescribed range | What the evidence is |
|---|---|---|
| BPC-157 | 250 to 500 mcg under the skin once a day | Practice convention. FDA found no human studies of BPC-157 given under the skin; small human studies used single injections into a joint or the bladder, or IV. |
| TB-500 | About 2 to 2.5 mg under the skin twice a week for 4 to 6 weeks, then about 2 mg once a week | Practice convention. FDA found no human studies of TB-500 by any route. |
| The stack course | Usually 8 to 12 weeks, then a break | No study of the combination in people or animals. |
Your provider sets your dose, schedule and how long you take it, based on your health, goals and other medicines. Do not change your dose without talking to them.
How the Wolverine stack is taken
Both peptides are usually given as small injections under the skin (subcutaneous), with the same kind of short, thin needle used for insulin. BPC-157 is often injected near the injured area; TB-500 can be injected anywhere under the skin because it is thought to act through the whole body.
Follow the instructions from the pharmacy that come with your prescription. Do not mix peptides in one syringe or change how they are prepared on your own.
Stacks are usually prescribed for a set number of weeks, followed by a break, and your provider checks in on how you are doing.
Wolverine stack side effects
Neither peptide has been through a large human trial, so true side-effect rates are not known. What has been reported is mostly mild:
- Redness, itching or a small bump where you inject
- Feeling tired or lightheaded
- Headache
- Nausea or an upset stomach
- Flushing or feeling warm
Both peptides encourage new blood vessels and cell growth, which is why providers avoid them in anyone who has or has had cancer. They are also not used during pregnancy or breastfeeding. Tell your provider about every medicine and supplement you take.
Is the Wolverine stack legal?
Yes, by prescription. Under the FDA's October 2026 interim policy, licensed 503A pharmacies may compound BPC-157 and TB-500 for an individual patient with a valid prescription. Neither peptide is FDA approved, and states can set their own rules.
Vials sold as "research use only" or "not for human consumption" are outside that policy. They are not made or tested for people and can be mislabeled or contaminated.
Both peptides are banned in competitive sport by the World Anti-Doping Agency (WADA). Athletes who are tested should not use them.
Prescription Wolverine stack vs. "research use only" peptides
| Rx.com | Research-use-only sellers | |
|---|---|---|
| Prescription and medical review | Yes. A U.S.-licensed provider reviews your health history and prescribes only if it is right for you. | No. Anyone can order, with no prescription and no medical review. |
| Who makes it | A licensed, state-inspected 503A compounding pharmacy prepares it for you under your prescription. | Unknown. The vials are labeled "research use only" or "not for human use." |
| Quality standards | It is made to pharmacy compounding standards, and the pharmacy is licensed and inspected by its state board of pharmacy. | None. Research chemicals do not have to meet any standard for people. |
| Legal status | It is covered by the FDA's October 2026 interim policy for compounded peptides. | It is outside the FDA policy and is not sold for people to use. |
How to get the Wolverine stack from Rx.com
U.S.-licensed providers
Online health intake
A short, confidential questionnaire about your injury, health and medications. No appointment, no waiting room.
Provider review
A U.S.-licensed provider reviews your answers and prescribes BPC-157, TB-500 or both only if they are right for you.
Compounded and shipped
A licensed U.S. 503A pharmacy compounds your prescription and ships it to your door.
Start with a short online health intake. A U.S.-licensed provider reviews it and prescribes only if the peptides are right for you, and a licensed 503A pharmacy compounds your prescription and ships it to your door.
Get the Wolverine stack first: join the waitlist
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Wolverine stack FAQs
What is the Wolverine stack?
Is the Wolverine peptide one peptide?
Does the Wolverine stack work?
What is the Wolverine stack dosage?
Can I take BPC-157 and TB-500 together?
How long does the Wolverine stack take to work?
Is the Wolverine stack safe?
Is the Wolverine stack legal?
Can I buy the Wolverine stack online?
Important safety information
BPC-157, TB-500, KPV, MOTS-c, Semax and Epitalon are not FDA approved. Their safety and effectiveness have not been established in large human trials, and the FDA's reviewers noted limited human safety data. Side effects and long-term risks are not fully known.
Do not use peptides if you are pregnant, breastfeeding or trying to conceive, or if you have or have had cancer, unless your provider says otherwise. Tell your provider about every medication and supplement you take. TB-500 is prohibited in competitive sport. Never use products labeled "research use only" or "not for human consumption."
References
- Regeneration or Risk? A Narrative Review of BPC-157 for Musculoskeletal Healing. Curr Rev Musculoskelet Med, 2025.
- Safety of Intravenous Infusion of BPC157 in Humans: A Pilot Study. Altern Ther Health Med, 2025.
- Intra-Articular Injection of BPC 157 for Multiple Types of Knee Pain. Altern Ther Health Med, 2021.
- Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500. Drug Test Anal, 2012.
- Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance. Sports Med, 2026.
- Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians. Am J Sports Med, 2026.
- FDA Pharmacy Compounding Advisory Committee briefing document: BPC-157, July 2026.
- FDA Pharmacy Compounding Advisory Committee briefing document: TB-500, July 2026.
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions. J Am Acad Orthop Surg Glob Res Rev, 2026.
BPC-157 and TB-500 articles & guides
How Much Does Compounded BPC-157 Cost in 2026? Injection and Capsule Prices Explained
Wolverine Stack: What BPC-157 + TB-500 Is, Benefits and Risks
Is BPC-157 Banned in Sports? 2026 WADA and USADA Rules Explained
BPC-157 Human Studies: What Clinical Trials Actually Show (and Don’t) in 2026
BPC-157 Prescription vs Research-Chemical Vials: Why the Source Matters
BPC-157 and TB-500 Stack: Prescription Options and Monthly Cost
KPV vs BPC-157 for Gut Healing: Which Peptide Is the Better Fit in 2026?
How to Get Compounded BPC-157 Once FDA Adds It to the 503A List
BPC-157 Injection vs Oral Capsules: Which Form to Get Prescribed?
BPC-157 for Gut Healing: What the 2026 Evidence Really Shows for Ulcerative Colitis & IBS
Thymosin Alpha-1 vs TB-500: Immune Support or Tissue Repair—Which Peptide Fits Your Research?
TB-500 (Thymosin β-4) for ACL Repair and Soft-Tissue Healing: What We Know in 2026
Start with a prescription, not a research vial
Confidential online visits with U.S.-licensed providers, and peptides compounded by a licensed U.S. pharmacy and shipped to your door if they are right for you.
Get BPC-157 · from $109/mo Join the stack waitlistPrescription required. Medications are prescribed only when clinically appropriate after an evaluation by a licensed independent provider. Compounded medications are prepared by a licensed pharmacy for an individual patient and are not FDA-approved; the FDA has not evaluated them for safety, effectiveness or quality. Individual results vary.
Peptide status: BPC-157 and TB-500 are not approved by the FDA. Under the FDA's October 2026 interim enforcement-discretion policy, licensed 503A pharmacies may compound them for individual patients with a valid prescription. Both are prohibited in competitive sport (WADA).
Medical services: All clinical evaluations, treatment planning and prescribing decisions are made by licensed independent medical providers. Rx.com provides the technology platform, does not employ healthcare providers and does not practice medicine.
