Impact-Site-Verification: 2721d812-1059-4270-b9fa-5c1654788cd1

Azasite Bottle — prescription drug image

Azasite

AzaSite 2.5ML of 1%

What is Azasite?

Azasite is a brand-name drug used to treat bacterial infections of the eye. Azasite is a brand-name of Azithromycin. The average Azasite price is about $194 for 2.5 mL of 1% ophthalmic solution. You can use our Rx.com savings offer to get an Azasite discount of up to 80% off of the retail price at participating pharmacies near you.

Prescription savings · · · ·

What is Azasite ?

Azasite is a brand-name drug used to treat bacterial infections of the eye. Azasite is a brand-name of Azithromycin. The average Azasite price is about $194 for 2.5 mL of 1% ophthalmic solution. You can use our Rx.com savings offer to get an Azasite discount of up to 80% off of the retail price at participating pharmacies near you.
  • Pain or swelling of your eyes
  • Burning, redness, stinging, or other eye irritation
  • Rash or itching around your eyes
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Blurred vision or any changes in vision
  • Tell your doctor if you are pregnant or breastfeeding.
  • Do not wear contact lenses until your infection is totally gone.
  • Call your doctor if your symptoms do not improve or if they get worse.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Pain or swelling of your eyes
  • Rash or itching around your eyes
What is AzaSite (azithromycin ophthalmic solution) used for?
AzaSite is an eye drop containing azithromycin 1% in a DuraSite vehicle. It is FDA-approved to treat bacterial conjunctivitis, commonly called pink eye, caused by susceptible isolates of CDC coryneform group G, Haemophilus influenzae, Staphylococcus aureus, the Streptococcus mitis group, and Streptococcus pneumoniae. Eye doctors sometimes also prescribe it for lid conditions such as blepharitis and meibomian gland dysfunction, and for ocular rosacea or dry eye linked to lid disease, but those uses are not FDA-approved and rest mainly on small studies. Use it only as your own prescriber directs.
How do you use AzaSite eye drops, and how long does a course last?
The labeled dosing is 1 drop in the affected eye or eyes twice daily, 8 to 12 hours apart, for the first 2 days, then 1 drop once daily for the next 5 days. That is a 7-day course in total. Finish the whole course even if your eye feels better early, which helps reduce the chance of resistant bacteria. Do not let the dropper tip touch your eye, your fingers, or any surface, because that can contaminate the bottle. Unopened bottles are kept refrigerated at 2 to 8 degrees C and may then be kept at room temperature for up to 14 days while in use; discard the bottle when your course is done.
Is there a generic version of AzaSite?
No. There is no FDA-approved, marketed, substitutable generic of azithromycin ophthalmic solution 1% in DuraSite in the United States, so you cannot simply ask the pharmacy to swap in a generic. Oral azithromycin tablets are a different product taken by mouth for different infections and are not a substitute for an eye drop. If cost is the issue, ask your prescriber whether another topical antibiotic, such as generic erythromycin ophthalmic ointment or generic ciprofloxacin ophthalmic solution, would be appropriate for your infection.
How much does AzaSite cost without insurance?
The cash price varies by pharmacy and by location, sometimes noticeably between stores in the same area, so there is no single number to quote. Enter your ZIP code above to see today's price near you and compare pharmacies before you fill. An Rx.com cash coupon is not insurance and is not tied to your coverage, so it can be used if you are uninsured, if you are on Medicare or another government plan that manufacturer savings cards typically exclude, or if a savings card was declined at the counter. You use it instead of insurance, not on top of it.
What are the side effects of azithromycin eye drops?
The most common side effect reported with AzaSite is eye irritation, in about 1 to 2 percent of patients. Reported in fewer than 1 percent were blurred vision, burning, stinging, contact dermatitis, corneal erosion, dry eye, eye discharge, itching, and punctate keratitis. Do not use it if you are allergic to azithromycin or any ingredient in the product. Serious allergic reactions including anaphylaxis, angioedema, and severe skin reactions have been reported with systemic azithromycin; stop the drops and seek care if a reaction occurs. Prolonged use may allow non-susceptible organisms, including fungi, to overgrow. This is not a complete list, so ask your doctor or pharmacist.
Can you wear contact lenses while using AzaSite?
No. Patients should not wear contact lenses while they have signs or symptoms of bacterial conjunctivitis. Ask your eye doctor when it is safe to go back to your lenses after your infection clears and your course is finished.
How much does Azasite cost without insurance?
The price of Azasite without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Azasite?
Common side effects of Azasite may include: Pain or swelling of your eyes, Burning, redness, stinging, or other eye irritation, Rash or itching around your eyes, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Blistering, peeling, red skin rash. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Azasite?
Generic versions may be available for Azasite. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Azasite on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Azasite?
The cheapest pharmacy for Azasite depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Azasite near you.

Azasite Coupons & Prices

AzaSite 2.5ML of 1%

Azasite Bottle — prescription drug image
Prescription
Azasite 2.5ml of 1% (0.8)
your area ·

If you have been handed a prescription for AzaSite and want to know what it will actually cost you, an AzaSite coupon from Rx.com can be used at the pharmacy counter to pay a cash discount price instead of full retail. AzaSite is a brand-name eye drop containing azithromycin ophthalmic solution 1% in a thickened DuraSite vehicle, FDA-approved to treat bacterial conjunctivitis (pink eye) caused by certain bacteria. There is no substitutable generic version of this exact eye drop on the US market, so the brand price is what you are working with. Enter your ZIP code above to see today's price at pharmacies near you before you fill.

What AzaSite is and how it works

AzaSite is azithromycin ophthalmic solution 1% (azithromycin monohydrate) delivered in DuraSite, a vehicle that thickens on contact with the eye so the drop stays on the surface longer instead of running off. Azithromycin is a macrolide antibiotic. Applied as a drop, it works against the bacteria on the surface of the eye that cause infection.

It was first approved by the FDA in 2007 (NDA 050810) for the treatment of bacterial conjunctivitis, commonly called pink eye, caused by susceptible isolates of CDC coryneform group G, Haemophilus influenzae, Staphylococcus aureus, Streptococcus mitis group, and Streptococcus pneumoniae. The labeled course is short: 1 drop in the affected eye or eyes twice daily, 8 to 12 hours apart, for the first 2 days, then 1 drop once daily for the next 5 days, for a 7-day course in total. Some eye doctors also prescribe it for lid conditions such as blepharitis and meibomian gland dysfunction; those uses are not FDA-approved and are supported mainly by small studies, so follow whatever your own eye doctor tells you rather than anything you read here.

Manufacturer savings card vs. the Rx.com cash coupon

Brand-name eye drops are usually where the sticker shock lands, and searches for an AzaSite coupon mostly turn up two things: a manufacturer program and cash discount cards. Manufacturer copay savings programs for brand drugs are generally limited to people with commercial (employer or marketplace) insurance, and they typically exclude anyone with Medicare, Medicaid, TRICARE, or other government coverage, and often the uninsured as well. Any current AzaSite program information would be posted on the manufacturer's own official AzaSite website. We do not link a savings-card page here because those deep links break often, and the terms, eligibility, and expiration dates vary and change without notice, so read them yourself before you count on one.

The Rx.com cash coupon works differently. It is not insurance and it is not tied to your coverage, so it is worth checking if you are uninsured, if you are on Medicare or another government plan that manufacturer cards shut out, if you have not met your deductible, or if a savings card was declined at the counter. You use it instead of insurance, not on top of it. Prices vary quite a bit from one pharmacy to the next, even between stores in the same town, so it pays to compare before you drop the prescription off. Enter your ZIP above to see today's price at pharmacies near you. If the cost is still a problem, tell your prescriber. Bacterial conjunctivitis can often be treated with more than one antibiotic drop, and there may be a cheaper option that is medically appropriate for you.

Is there a generic, and what are the alternatives?

There is no FDA-approved, marketed, substitutable generic of AzaSite in the United States, so the usual biggest savings lever, swapping to a generic of the same product, is not available here. Oral azithromycin tablets (the generic of Zithromax) contain the same antibiotic but are a completely different product taken by mouth for different, systemic infections. They are not a substitute for an eye drop, and you should never assume one can replace the other.

What may be worth asking your prescriber about are other topical antibiotics used for eye infections, each with its own label, dosing schedule, and price:

  • Erythromycin ophthalmic ointment, another macrolide, available as a generic
  • Vigamox (moxifloxacin) and Besivance (besifloxacin), fluoroquinolone drops
  • Generic ciprofloxacin ophthalmic solution
  • TobraDex (tobramycin with dexamethasone), which adds a steroid and is only appropriate in certain situations your doctor decides

Prices for all of these vary by pharmacy, and cheaper is not automatically better, since the right choice depends on what is causing your infection. Bring the comparison to your prescriber rather than switching on your own.

Safety, side effects, and using the drops correctly

AzaSite has no boxed warning. It should not be used by anyone with a hypersensitivity to azithromycin or to any component of the product. It is for topical use in the eye only: it must never be injected under the conjunctiva, put directly into the anterior chamber of the eye, or given systemically. Serious allergic reactions, including anaphylaxis, angioedema, and severe skin reactions, have been reported with systemic azithromycin. If you develop a hypersensitivity reaction, stop the drug and get medical care. Prolonged use can allow non-susceptible organisms, including fungi, to overgrow.

The most common side effect is eye irritation, reported in roughly 1 to 2 percent of patients. Reported in under 1 percent were blurred vision, burning, stinging, contact dermatitis, corneal erosion, dry eye, eye discharge, itching, and punctate keratitis. A few practical points: do not wear contact lenses while you have signs or symptoms of bacterial conjunctivitis; do not let the dropper tip touch your eye, your fingers, or any surface, since that can contaminate the bottle; and finish the full 7-day course even if your eye looks and feels better sooner, which helps reduce the chance of resistant bacteria. Unopened bottles are stored in the refrigerator (2 to 8 degrees C), and once in use may be kept at room temperature for up to 14 days; discard the bottle after your course is finished. This is a summary, not medical advice, and not a complete list of side effects. Talk with your doctor or pharmacist about your own situation.

Sources & accuracy

This Azasite information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Azasite on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.