Captopril-Hydrochlorothiazide
Captopril-hydroCHLOROthiazide 25-25MG
What is Captopril-Hydrochlorothiazide?
Captopril-Hydrochlorothiazide is a combination medication used in the treatment of hypertension. Captopril works by inhibiting the angiotensin-converting enzyme, decreasing blood pressure and improving blood flow, while Hydrochlorothiazide is a diuretic that helps reduce excess fluid in the body. This synergistic effect not only lowers blood pressure but also reduces the risk associated with high blood pressure, such as stroke and heart attacks.Side Effects
- Dry mouth, increased thirst, muscle cramps, nausea, vomiting
- Sores, reddish patch or irritated area, shiny bump, pink growth, or white, yellow or waxy scar-like area on the skin
- Fever, chills, cough, sore throat, and body aches
Warnings
- This medicine is not safe to take during pregnancy, especially in your second or third trimester. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Tell your doctor if you are breastfeeding, or if you have kidney disease (including patients on dialysis), liver disease, heart or blood vessel disease, heart failure, diabetes, gout, collagen-vascular disease (including lupus or scleroderma), or a history of asthma or allergies, or if you have had surgery of the nerves.
- This medicine may cause the following problems:Angioedema (severe swelling), including head, neck, and intestinal swellingLow blood pressureLiver problemsKidney problemsHigh blood sugar and uric acidIncreased risk of skin cancer
- This medicine could lower your blood pressure too much, especially when you first use it or if you are dehydrated. Stand or sit up slowly if you feel lightheaded or dizzy.
- Drink plenty of fluids if you exercise, sweat more than usual, or have diarrhea or vomiting while you are using this medicine.
Prescription savings · · · ·
What is Captopril-Hydrochlorothiazide ?
Captopril-Hydrochlorothiazide is a combination medication used in the treatment of hypertension. Captopril works by inhibiting the angiotensin-converting enzyme, decreasing blood pressure and improving blood flow, while Hydrochlorothiazide is a diuretic that helps reduce excess fluid in the body. This synergistic effect not only lowers blood pressure but also reduces the risk associated with high blood pressure, such as stroke and heart attacks.- Dry mouth, increased thirst, muscle cramps, nausea, vomiting
- Sores, reddish patch or irritated area, shiny bump, pink growth, or white, yellow or waxy scar-like area on the skin
- Fever, chills, cough, sore throat, and body aches
- Unusual bleeding, bruising, or weakness
- Dark urine or pale stools, loss of appetite, stomach pain, yellow skin or eyes
- Lightheadedness or fainting
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Change in how much or how often you urinate
- Chest pain, fast, pounding, or uneven heartbeat
- Confusion, weakness, numbness or tingling in your hands, feet, or lips
- Rapid weight gain, swelling in your hands, ankles, or feet
- This medicine is not safe to take during pregnancy, especially in your second or third trimester. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Tell your doctor if you are breastfeeding, or if you have kidney disease (including patients on dialysis), liver disease, heart or blood vessel disease, heart failure, diabetes, gout, collagen-vascular disease (including lupus or scleroderma), or a history of asthma or allergies, or if you have had surgery of the nerves.
- This medicine may cause the following problems:Angioedema (severe swelling), including head, neck, and intestinal swellingLow blood pressureLiver problemsKidney problemsHigh blood sugar and uric acidIncreased risk of skin cancer
- This medicine could lower your blood pressure too much, especially when you first use it or if you are dehydrated. Stand or sit up slowly if you feel lightheaded or dizzy.
- Drink plenty of fluids if you exercise, sweat more than usual, or have diarrhea or vomiting while you are using this medicine.
- Do not stop using this medicine without asking your doctor, even if you feel well. This medicine will not cure your high blood pressure, but it will help keep it in the normal range. You may have to take blood pressure medicine for the rest of your life.
- Tell any doctor or dentist who treats you that you are using this medicine, especially before you have any type of surgery or medical tests.
- This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
- This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Captopril-Hydrochlorothiazide Coupons & Prices
Captopril-hydroCHLOROthiazide 25-25MG
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Captopril-hydrochlorothiazide is a combination tablet that pairs an ACE inhibitor with a thiazide diuretic to help control high blood pressure, and cash prices for it can differ quite a bit between pharmacies. If you're searching for a captopril-hydrochlorothiazide coupon, enter your ZIP code above to compare prices at pharmacies near you.
What is captopril-hydrochlorothiazide and how does it work?
This tablet combines captopril, an ACE (angiotensin-converting enzyme) inhibitor that relaxes blood vessels, with hydrochlorothiazide, a thiazide diuretic ("water pill") that helps the kidneys remove excess salt and fluid. It's indicated for the treatment of hypertension in patients who need more than one type of blood-pressure medicine to reach their goal. It's only available as a generic today; the original brand, Capozide, is no longer marketed.
Comparing prices for captopril-hydrochlorothiazide
Because this is a generic-only combination, prices are set independently by each pharmacy and can vary widely depending on where you fill it and which manufacturer's tablets are in stock. Rx.com compares prices across more than 60,000 U.S. pharmacies, so it's worth checking a few options nearby, whether or not you have prescription insurance.
Alternatives for blood pressure control
- Lisinopril — another ACE inhibitor, often combined separately with a diuretic or taken alone.
- Losartan — an ARB sometimes used as an alternative to an ACE inhibitor, including a losartan-hydrochlorothiazide combination tablet.
- Hydrochlorothiazide alone — the diuretic component, sometimes prescribed separately so each medicine's dose can be adjusted independently.
Your doctor chooses your regimen based on your blood pressure goals, kidney function, and any other health conditions.
Boxed warning and other safety information
Boxed warning — fetal toxicity: Medicines that act on the renin-angiotensin system, including the captopril in this combination, can cause injury and death to a developing fetus when used during the second and third trimesters of pregnancy. If you become pregnant, tell your doctor right away so this medicine can be stopped as soon as possible and an alternative considered.
Other cautions include the possibility of low blood pressure, elevated potassium levels, kidney function changes, and sun sensitivity from the thiazide component. This isn't a complete list of warnings; review your full health history and medication list with your doctor or pharmacist before starting.
This Captopril-Hydrochlorothiazide information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Captopril-Hydrochlorothiazide on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.
