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Clarithromycin Er Tablet — prescription drug image

Clarithromycin Er

Clarithromycin ER 500MG

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What is Clarithromycin Er?

Clarithromycin ER (extended release) is a macrolide antibiotic used primarily to treat various bacterial infections, including but not limited to pneumonia, bronchitis, and infections of the ears, skin, and respiratory tract. This medication works by inhibiting the growth of bacteria, and its extended-release formulation allows for convenient once-daily dosing. It is essential to follow a healthcare professional's directions when using this antibiotic to ensure its effectiveness and prevent the development of antibiotic-resistant bacteria.

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What is Clarithromycin Er ?

Clarithromycin ER (extended release) is a macrolide antibiotic used primarily to treat various bacterial infections, including but not limited to pneumonia, bronchitis, and infections of the ears, skin, and respiratory tract. This medication works by inhibiting the growth of bacteria, and its extended-release formulation allows for convenient once-daily dosing. It is essential to follow a healthcare professional's directions when using this antibiotic to ensure its effectiveness and prevent the development of antibiotic-resistant bacteria.
  • Blistering, peeling, red skin rash
  • Severe diarrhea that may contain blood
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Fast, slow, pounding, or uneven heartbeat, chest pain
  • Severe nausea, vomiting, stomach pain
  • Dark urine, pale stools, loss of appetite, yellow skin or eyes
  • Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, heart disease, diabetes, myasthenia gravis, or a history of porphyria. Tell your doctor if anyone in your family has heart rhythm problems.
  • This medicine may cause the following problems:Serious skin reactionsChanges in heart rhythm (including QT prolongation)Liver problems
  • This medicine may make you dizzy or confused. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine. It may occur 2 months or more after you stop using this medicine.
  • Call your doctor if your symptoms do not improve or if they get worse.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
What is clarithromycin ER used to treat?
Clarithromycin ER (extended-release) is FDA-approved for adults with certain mild-to-moderate bacterial infections: acute maxillary sinusitis, acute bacterial worsening of chronic bronchitis, and community-acquired pneumonia caused by bacteria that respond to it. It only treats bacterial infections and does not work against viruses like colds or the flu.
What is the difference between clarithromycin ER and regular clarithromycin?
Clarithromycin ER is an extended-release tablet taken once a day, while regular (immediate-release) clarithromycin is usually taken twice a day. The immediate-release form is also used for infections the ER form is not indicated for, such as H. pylori eradication. Your provider chooses the form that fits your infection and dosing needs.
Can you take clarithromycin extended-release tablets with food?
Clarithromycin extended-release tablets are generally taken with food. Swallow the tablet whole and do not crush, chew, or split it, since that can affect how the medicine is released. Follow the exact directions on your prescription label and ask your pharmacist if you are unsure.
What are the most serious side effects of clarithromycin?
The most serious risks include changes in heart rhythm (QT prolongation and related arrhythmias), liver injury that can rarely be severe, a serious intestinal infection called C. difficile-associated diarrhea, and severe skin or allergic reactions. In people with existing coronary heart disease, providers often choose a different antibiotic when possible. Seek medical care right away for fainting, a fast or irregular heartbeat, yellowing skin or eyes, severe or bloody diarrhea, or a spreading rash.
What medications should not be taken with clarithromycin?
Clarithromycin has many important interactions because it strongly affects an enzyme (CYP3A4) that breaks down other drugs. It should not be combined with certain statins such as lovastatin and simvastatin, with ergot medicines, pimozide, cisapride, or lomitapide, or with colchicine in people who have kidney or liver problems. It is also generally avoided with certain heart-rhythm medicines. Give your provider and pharmacist a full list of everything you take, including supplements, before starting it.
How much does Clarithromycin Er cost without insurance?
The price of Clarithromycin Er without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 63% off retail prices with a free Rx.com coupon.
What are the common side effects of Clarithromycin Er?
Common side effects of Clarithromycin Er may include: Blistering, peeling, red skin rash, Severe diarrhea that may contain blood, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Fast, slow, pounding, or uneven heartbeat, chest pain, Severe nausea, vomiting, stomach pain. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Clarithromycin Er?
Generic versions may be available for Clarithromycin Er. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Clarithromycin Er on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Clarithromycin Er?
The cheapest pharmacy for Clarithromycin Er depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Clarithromycin Er near you.

Clarithromycin Er Coupons & Prices

Clarithromycin ER 500MG

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Clarithromycin Er Tablet — prescription drug image
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Clarithromycin Er 500mg (10)
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Clarithromycin Er prices by dosage

Lowest cash price with a free Rx.com coupon vs. the average retail price.

Dosage Quantity Retail price Rx.com price
500mg · Tablet 20 $128.99 $44.41

Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.

Looking for a clarithromycin ER coupon? Clarithromycin extended-release is the once-daily generic form of the macrolide antibiotic once sold as Biaxin XL (a brand largely discontinued in the US). Because it is already available as a low-cost generic, you usually do not need a brand-name savings card — but the cash price still varies widely from one pharmacy to the next, so comparing matters. Rx.com checks prices across more than 60,000 pharmacies so you can find a lower price near you. Enter your ZIP above to see today's price at pharmacies in your area.

What is clarithromycin ER and how does it work?

Clarithromycin is a macrolide antibiotic. The extended-release (ER) tablet releases the medicine slowly so it can be taken once a day instead of twice. It is FDA-approved for certain mild-to-moderate bacterial infections in adults, including acute maxillary sinusitis, acute bacterial worsening (exacerbation) of chronic bronchitis, and community-acquired pneumonia caused by bacteria that respond to it.

Antibiotics like clarithromycin only work against bacteria. They do not treat viral infections such as the common cold or the flu. Your provider decides whether an antibiotic is appropriate and which one fits your infection.

How much does clarithromycin ER cost without insurance?

Clarithromycin ER is a generic, so it is generally inexpensive compared with brand-name antibiotics. Even so, the cash price for the same tablet strength and quantity can differ a lot between pharmacies, which is why it pays to compare before you fill. A discount price from Rx.com is a cash price and does not use your insurance — some people find it lower than a copay, but it is worth checking both.

To see what you would actually pay today, enter your ZIP above. Rx.com compares more than 60,000 pharmacies so you can pick the lowest price near you. There is no manufacturer savings card for clarithromycin ER; because it is a generic, a coupon price at the pharmacy counter is the practical way to save.

Clarithromycin ER vs. other antibiotics

Clarithromycin ER is the once-daily version of clarithromycin. The regular (immediate-release) form is taken twice a day and is also used for H. pylori and certain other infections that the ER form is not indicated for. Your provider chooses the form that matches your infection and dosing needs.

Other antibiotics your provider may consider depending on the infection and your history include the macrolides azithromycin and erythromycin, or the penicillin-class antibiotic amoxicillin. Which one is right depends on the type of bacteria, allergies, other medicines you take, and your medical history — not on price alone. You can compare prices on each of those drug pages once your provider selects one.

Safety and drug interactions to know

This is general information, not medical advice — always follow your provider's and pharmacist's instructions. Clarithromycin can prolong the QT interval (a change in heart rhythm), so it is generally avoided in people with a history of QT prolongation, certain irregular heartbeats, low potassium or magnesium, very slow heart rate, or who take certain heart-rhythm drugs. It can also, though uncommonly, cause liver injury, C. difficile-associated diarrhea, and serious skin or allergic reactions. In people with existing coronary heart disease, providers often choose an alternative when one is available.

Clarithromycin is a strong CYP3A4 inhibitor and has many important drug interactions. It should not be combined with certain cholesterol statins such as lovastatin and simvastatin (risk of severe muscle breakdown), ergot medicines, pimozide, cisapride, lomitapide, or with colchicine in people who have kidney or liver problems. Tell your provider and pharmacist about every medicine and supplement you take, and do not start clarithromycin if you had liver problems or cholestatic jaundice from it before. It is generally not recommended in pregnancy unless there is no alternative.

Sources & accuracy

This Clarithromycin Er information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Clarithromycin Er on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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