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Dimethyl Fumarate

Dimethyl Fumarate 60 Capsules Delayed Release

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What is Dimethyl Fumarate?

Dimethyl fumarate is a medication primarily used for the treatment of relapsing forms of multiple sclerosis (MS). It works by activating the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway, which helps protect against oxidative stress-induced cellular damage. Dimethyl fumarate is also noted for its anti-inflammatory properties, which contribute to its efficacy in slowing disease progression and reducing relapses in MS patients.

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What is Dimethyl Fumarate ?

Dimethyl fumarate is a medication primarily used for the treatment of relapsing forms of multiple sclerosis (MS). It works by activating the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway, which helps protect against oxidative stress-induced cellular damage. Dimethyl fumarate is also noted for its anti-inflammatory properties, which contribute to its efficacy in slowing disease progression and reducing relapses in MS patients.
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, yellow skin or eyes
  • Fever or chills, cough, sore throat, body aches
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Back pain, blurred vision, dizziness, fever, headache, seizures, tiredness
  • Black, tarry stools, constipation, diarrhea, stomach pain or upset, vomiting of blood or material that looks like coffee grounds
  • Chest pain, trouble breathing
  • Change in how much or how often you urinate, lower back or side pain, painful or difficult urination
  • Painful blisters on trunk of the body
  • Warmth or redness in your face, neck, arms, or upper chest
  • This medicine lowers the number of white blood cells. This weakens your immune system, so you may get infections more easily. Wash your hands often. Avoid people who are sick.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding, or if you have stomach or bowel problems, any type of infection (including herpes zoster), or a weak immune system.
  • This medicine may cause the following problems:Increased risk of infections, which may be life-threatening, including progressive multifocal leukoencephalopathy (PML) or herpes zoster (shingles)Liver problemsSerious stomach or bowel problems (including bleeding, blockage, perforation, or ulcers)
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
What is dimethyl fumarate (Tecfidera) used for?
Dimethyl fumarate is FDA-approved to treat relapsing forms of multiple sclerosis in adults, including clinically isolated syndrome, relapsing-remitting MS, and active secondary progressive disease. It's taken as a delayed-release capsule twice daily and works by reducing inflammation and helping protect against nerve damage; it does not cure MS.
What are the side effects of dimethyl fumarate?
The most common side effects are flushing and gastrointestinal upset such as nausea, diarrhea, and abdominal pain, which often improve over time. More serious risks include a rare brain infection called PML (linked to prolonged low lymphocyte counts), anaphylaxis or angioedema (which can happen after the first dose or later), serious GI reactions such as ulceration or bleeding, and liver enzyme elevations. Talk to your doctor about anything new or worsening while on this medication.
Is there a generic version of Tecfidera and how much does it cost?
Yes, a generic version of Tecfidera (dimethyl fumarate) is available. Cash prices vary by pharmacy and location, so the best way to see current pricing is to enter your ZIP code above and compare pharmacies near you.
How does dimethyl fumarate work for multiple sclerosis?
Dimethyl fumarate is an Nrf2 activator, a type of oral disease-modifying therapy. It's thought to work by decreasing inflammation and helping protect nerve cells from damage, which can help control the course of relapsing MS. It does not cure the disease.
What blood tests are needed while taking dimethyl fumarate?
Your prescriber should order a complete blood count (CBC) with lymphocyte count before you start dimethyl fumarate, again at around 6 months, and then periodically (roughly every 6 to 12 months) after that. This monitors for prolonged low lymphocyte counts, which have been linked to a rare but serious brain infection called PML. Your doctor may interrupt treatment if your lymphocyte count drops too low.
How much does Dimethyl Fumarate cost without insurance?
The price of Dimethyl Fumarate without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Dimethyl Fumarate?
Common side effects of Dimethyl Fumarate may include: Dark urine or pale stools, nausea, vomiting, loss of appetite, yellow skin or eyes, Fever or chills, cough, sore throat, body aches, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Back pain, blurred vision, dizziness, fever, headache, seizures, tiredness, Black, tarry stools, constipation, diarrhea, stomach pain or upset, vomiting of blood or material that looks like coffee grounds. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Dimethyl Fumarate?
Generic versions may be available for Dimethyl Fumarate. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Dimethyl Fumarate on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Dimethyl Fumarate?
The cheapest pharmacy for Dimethyl Fumarate depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Dimethyl Fumarate near you.

Dimethyl Fumarate Coupons & Prices

Dimethyl Fumarate 60 Capsules Delayed Release

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Dimethyl Fumarate 60 capsules delayed release (1)
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Compounded GLP-1 medications are not FDA-approved and are prepared by state-licensed compounding pharmacies. They are not affiliated with, endorsed by, or equivalent to any brand-name medication or manufacturer. Prescription required; eligibility is determined by a licensed provider. Prices are estimates and may vary.

If you're comparing dimethyl fumarate coupon offers, here's what matters: dimethyl fumarate (the generic form of Tecfidera) is already an established generic option for relapsing forms of multiple sclerosis, but the cash price for the same capsule and dosage can still swing widely from one pharmacy to the next. Rx.com compares dimethyl fumarate pricing across more than 60,000 U.S. pharmacies so you can enter your ZIP code above and see today's price near you before you fill.

What is dimethyl fumarate and how does it work?

Dimethyl fumarate is an oral disease-modifying therapy (a fumaric acid ester that activates the Nrf2 pathway) approved by the FDA for relapsing forms of multiple sclerosis in adults, including clinically isolated syndrome, relapsing-remitting MS, and active secondary progressive disease. It's taken as a delayed-release capsule twice daily.

It works by reducing inflammation and helping protect nerve cells from damage. It does not cure MS — it's meant to help control the course of the disease over time, and it should only be started or stopped under a prescriber's guidance.

Dimethyl fumarate cost and coupon savings

A generic version of Tecfidera is available, which typically opens the door to lower-cost options versus paying for the brand. But "generic" doesn't mean one fixed price — cash prices for dimethyl fumarate vary by pharmacy, by location, and by which generic manufacturer's product is in stock, so it's worth comparing before you fill a twice-daily prescription you'll likely refill for months. Enter your ZIP code above to compare dimethyl fumarate prices across pharmacies near you.

Tecfidera's manufacturer also offers a copay support program for eligible patients on the brand product, listed on the official Tecfidera website; program terms and eligibility vary and should be checked directly with the manufacturer or your pharmacist.

Tecfidera vs. other MS therapies

Dimethyl fumarate generic is the equivalent of the brand Tecfidera — same active ingredient, same dosage form. It's not the same product as Vumerity (diroximel fumarate) or Bafiertam (monomethyl fumarate); these are related fumarate-class MS drugs but are distinct FDA-approved products, not interchangeable generics of dimethyl fumarate.

If you and your neurologist are weighing options beyond the fumarate class, other disease-modifying therapies for relapsing MS include Ocrevus, Gilenya, Aubagio, and Copaxone. Which therapy fits best depends on your specific diagnosis, other health conditions, and how you tolerate side effects — that's a conversation for your prescriber, not a coupon page.

Safety information

Dimethyl fumarate carries several important warnings patients should know about, though it does not carry an FDA boxed warning. Progressive multifocal leukoencephalopathy (PML), a rare but serious brain infection, has been reported in patients with prolonged low lymphocyte counts; your prescriber should check a CBC with lymphocyte count before you start, again around 6 months, and periodically after that. Anaphylaxis and angioedema can occur after the first dose or at any point during treatment — seek emergency care for difficulty breathing, hives, or swelling of the throat or tongue. Serious gastrointestinal reactions, including perforation, ulceration, bleeding, or obstruction, have occurred (mostly in the first 6 months), and liver enzyme elevations have been reported.

The most common side effects are flushing and GI upset (nausea, diarrhea, abdominal pain), which often ease over time; taking the capsule with food, or using aspirin beforehand as your prescriber directs, may reduce flushing. Dimethyl fumarate should not be used by anyone with a known hypersensitivity to it or its ingredients. This is general information, not medical advice — talk with your doctor or pharmacist about your specific situation.

Sources & accuracy

This Dimethyl Fumarate information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Dimethyl Fumarate on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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