Dimethyl Fumarate
Dimethyl Fumarate 60 Capsules Delayed Release
What is Dimethyl Fumarate?
Dimethyl fumarate is a medication primarily used for the treatment of relapsing forms of multiple sclerosis (MS). It works by activating the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway, which helps protect against oxidative stress-induced cellular damage. Dimethyl fumarate is also noted for its anti-inflammatory properties, which contribute to its efficacy in slowing disease progression and reducing relapses in MS patients.Side Effects
- Dark urine or pale stools, nausea, vomiting, loss of appetite, yellow skin or eyes
- Fever or chills, cough, sore throat, body aches
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Warnings
- This medicine lowers the number of white blood cells. This weakens your immune system, so you may get infections more easily. Wash your hands often. Avoid people who are sick.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding, or if you have stomach or bowel problems, any type of infection (including herpes zoster), or a weak immune system.
- This medicine may cause the following problems:Increased risk of infections, which may be life-threatening, including progressive multifocal leukoencephalopathy (PML) or herpes zoster (shingles)Liver problemsSerious stomach or bowel problems (including bleeding, blockage, perforation, or ulcers)
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Prescription savings · · · ·
What is Dimethyl Fumarate ?
Dimethyl fumarate is a medication primarily used for the treatment of relapsing forms of multiple sclerosis (MS). It works by activating the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway, which helps protect against oxidative stress-induced cellular damage. Dimethyl fumarate is also noted for its anti-inflammatory properties, which contribute to its efficacy in slowing disease progression and reducing relapses in MS patients.- Dark urine or pale stools, nausea, vomiting, loss of appetite, yellow skin or eyes
- Fever or chills, cough, sore throat, body aches
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Back pain, blurred vision, dizziness, fever, headache, seizures, tiredness
- Black, tarry stools, constipation, diarrhea, stomach pain or upset, vomiting of blood or material that looks like coffee grounds
- Chest pain, trouble breathing
- Change in how much or how often you urinate, lower back or side pain, painful or difficult urination
- Painful blisters on trunk of the body
- Warmth or redness in your face, neck, arms, or upper chest
- This medicine lowers the number of white blood cells. This weakens your immune system, so you may get infections more easily. Wash your hands often. Avoid people who are sick.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding, or if you have stomach or bowel problems, any type of infection (including herpes zoster), or a weak immune system.
- This medicine may cause the following problems:Increased risk of infections, which may be life-threatening, including progressive multifocal leukoencephalopathy (PML) or herpes zoster (shingles)Liver problemsSerious stomach or bowel problems (including bleeding, blockage, perforation, or ulcers)
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Dimethyl Fumarate Coupons & Prices
Dimethyl Fumarate 60 Capsules Delayed Release
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If you're comparing dimethyl fumarate coupon offers, here's what matters: dimethyl fumarate (the generic form of Tecfidera) is already an established generic option for relapsing forms of multiple sclerosis, but the cash price for the same capsule and dosage can still swing widely from one pharmacy to the next. Rx.com compares dimethyl fumarate pricing across more than 60,000 U.S. pharmacies so you can enter your ZIP code above and see today's price near you before you fill.
What is dimethyl fumarate and how does it work?
Dimethyl fumarate is an oral disease-modifying therapy (a fumaric acid ester that activates the Nrf2 pathway) approved by the FDA for relapsing forms of multiple sclerosis in adults, including clinically isolated syndrome, relapsing-remitting MS, and active secondary progressive disease. It's taken as a delayed-release capsule twice daily.
It works by reducing inflammation and helping protect nerve cells from damage. It does not cure MS — it's meant to help control the course of the disease over time, and it should only be started or stopped under a prescriber's guidance.
Dimethyl fumarate cost and coupon savings
A generic version of Tecfidera is available, which typically opens the door to lower-cost options versus paying for the brand. But "generic" doesn't mean one fixed price — cash prices for dimethyl fumarate vary by pharmacy, by location, and by which generic manufacturer's product is in stock, so it's worth comparing before you fill a twice-daily prescription you'll likely refill for months. Enter your ZIP code above to compare dimethyl fumarate prices across pharmacies near you.
Tecfidera's manufacturer also offers a copay support program for eligible patients on the brand product, listed on the official Tecfidera website; program terms and eligibility vary and should be checked directly with the manufacturer or your pharmacist.
Tecfidera vs. other MS therapies
Dimethyl fumarate generic is the equivalent of the brand Tecfidera — same active ingredient, same dosage form. It's not the same product as Vumerity (diroximel fumarate) or Bafiertam (monomethyl fumarate); these are related fumarate-class MS drugs but are distinct FDA-approved products, not interchangeable generics of dimethyl fumarate.
If you and your neurologist are weighing options beyond the fumarate class, other disease-modifying therapies for relapsing MS include Ocrevus, Gilenya, Aubagio, and Copaxone. Which therapy fits best depends on your specific diagnosis, other health conditions, and how you tolerate side effects — that's a conversation for your prescriber, not a coupon page.
Safety information
Dimethyl fumarate carries several important warnings patients should know about, though it does not carry an FDA boxed warning. Progressive multifocal leukoencephalopathy (PML), a rare but serious brain infection, has been reported in patients with prolonged low lymphocyte counts; your prescriber should check a CBC with lymphocyte count before you start, again around 6 months, and periodically after that. Anaphylaxis and angioedema can occur after the first dose or at any point during treatment — seek emergency care for difficulty breathing, hives, or swelling of the throat or tongue. Serious gastrointestinal reactions, including perforation, ulceration, bleeding, or obstruction, have occurred (mostly in the first 6 months), and liver enzyme elevations have been reported.
The most common side effects are flushing and GI upset (nausea, diarrhea, abdominal pain), which often ease over time; taking the capsule with food, or using aspirin beforehand as your prescriber directs, may reduce flushing. Dimethyl fumarate should not be used by anyone with a known hypersensitivity to it or its ingredients. This is general information, not medical advice — talk with your doctor or pharmacist about your specific situation.
This Dimethyl Fumarate information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Dimethyl Fumarate on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.