Diphenoxylate-Atropine Coupons & Prices

Diphenoxylate-atropine (brand names Lomotil, Lonox, and Lomanate) is a generic antidiarrheal combination, so if you're comparing a diphenoxylate-atropine coupon against pharmacy cash prices, the real savings lever is usually which pharmacy you use, not which coupon you use — prices for this generic can vary widely from one pharmacy to the next. Rx.com compares pricing across 60,000+ U.S. pharmacies so you can enter your ZIP above and see today's price near you before you fill.

What is diphenoxylate-atropine and how does it work?

Diphenoxylate-atropine combines two ingredients with different jobs. Diphenoxylate is chemically related to the opioid meperidine and works on opioid receptors in the gut to slow down intestinal movement, which reduces diarrhea. Atropine is added in a low, subtherapeutic dose specifically to discourage people from taking more than the recommended amount — at higher doses it causes unpleasant anticholinergic effects. It's FDA-approved as an adjunctive therapy for diarrhea in patients 13 and older, meaning it's meant to be used alongside fluid and electrolyte replacement, not as a stand-alone first-line treatment.

Diphenoxylate-atropine cost without insurance

Diphenoxylate-atropine is available as a generic, and generics for this combination are generally accessible, but the exact cash price still depends heavily on which pharmacy you walk into — chain and independent pharmacies price the same generic very differently. Rather than assuming any single coupon or pharmacy has the lowest price, it's worth comparing before you fill. Enter your ZIP code above to see today's price at pharmacies near you, side by side.

Diphenoxylate-atropine vs. other diarrhea options

Diphenoxylate-atropine is a prescription-only, Schedule V controlled combination, which sets it apart from over-the-counter options. Loperamide (the active ingredient in Imodium) is an OTC antidiarrheal that works on gut opioid receptors similarly but is not a controlled substance and doesn't include an anticholinergic component. Bismuth subsalicylate (Pepto-Bismol) is another OTC option some people use for diarrhea and upset stomach. If nausea is part of the picture, ondansetron is a separate prescription option for that symptom specifically. Your provider or pharmacist can help you weigh which option fits your situation — this isn't a recommendation to switch on your own.

Safety information

Diphenoxylate-atropine carries a boxed warning: it is contraindicated in children under 6 years old, because severe respiratory depression and coma leading to permanent brain damage or death have occurred in this age group. Toxicity can also be delayed, so anyone who takes too much needs extended monitoring even if symptoms initially seem absent. Because diphenoxylate is chemically related to meperidine, the combination is a Schedule V controlled substance with some potential for abuse or dependence. The atropine component can cause dry mouth, blurred vision, or urinary retention. It should not be used in obstructive jaundice, and it's used cautiously in ulcerative colitis (risk of toxic megacolon) or liver impairment. This is general information, not medical advice — talk to your doctor or pharmacist about whether it's right for you.