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Loperamide Hcl

Loperamide HCl 2MG

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What is Loperamide Hcl?

Loperamide HCl is a medication used to help control sudden diarrhea, including diarrhea from travel. It works by slowing down bowel movements and reducing fluid in the intestines.

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What is Loperamide Hcl ?

Loperamide HCl is a medication used to help control sudden diarrhea, including diarrhea from travel. It works by slowing down bowel movements and reducing fluid in the intestines.

Source: MedlinePlus, U.S. National Library of Medicine

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Bloating, blood in the stools, constipation, fever, loss of appetite, nausea, vomiting, stomach pain
  • Chest pain, trouble breathing, fainting, fast, slow, or uneven heartbeat
  • Changes in vision, such as trouble focusing
  • Drowsiness or dizziness
  • Tell your doctor if you are pregnant, or if you have kidney disease, liver disease, heart disease, HIV or AIDS, or a history of heart rhythm problems.
  • Do not breastfeed during treatment with this medicine.
  • This medicine may make you dizzy, drowsy, or tired. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
  • This medicine may cause the following problems:Heart rhythm problem (including QT prolongation, torsades de pointes, ventricular arrhythmias)Increased risk for stomach or bowel problems (including ileus, megacolon, toxic megacolon)
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Call your doctor if your symptoms do not improve or if they get worse.
What is loperamide (Imodium) used for?
Loperamide is used to control and relieve acute nonspecific diarrhea and chronic diarrhea associated with inflammatory bowel disease, and to reduce the volume of discharge from an ileostomy. It is also commonly used for traveler's diarrhea. It works by slowing movement in the gut so stool passes more slowly and the body reabsorbs more water.
How much loperamide can you take in a day?
Over the counter, the maximum is 8 mg per day for up to 2 days. Under a prescription and a provider's direction, the maximum is 16 mg per day. Do not exceed the recommended dose, because higher amounts can cause serious heart problems.
Can loperamide cause heart problems?
At normal, recommended doses loperamide is generally safe. However, the FDA has warned that higher-than-recommended doses can cause serious, life-threatening heart rhythm problems, including QT prolongation, Torsades de Pointes, fainting, and cardiac arrest, with deaths reported. These events are largely linked to abuse or misuse. Avoid loperamide if you have an abnormal heart rhythm, and never take more than directed.
How long does loperamide take to work?
Loperamide begins slowing the gut soon after you take it, and many people notice improvement within a few hours. Follow the label or your provider's directions for repeat dosing, and do not exceed the daily maximum. If diarrhea lasts more than 2 days or gets worse, stop and contact your provider.
Is loperamide available over the counter or prescription only?
Both. Loperamide is sold over the counter (with a maximum of 8 mg per day for up to 2 days) and is also available by prescription at a higher daily limit under a provider's care. A substitutable generic is available, and it is not a controlled substance.
How much does Loperamide Hcl cost without insurance?
The price of Loperamide Hcl without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 30% off retail prices with a free Rx.com coupon.
What are the common side effects of Loperamide Hcl?
Common side effects of Loperamide Hcl may include: Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Bloating, blood in the stools, constipation, fever, loss of appetite, nausea, vomiting, stomach pain, Chest pain, trouble breathing, fainting, fast, slow, or uneven heartbeat, Changes in vision, such as trouble focusing, Drowsiness or dizziness. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Loperamide Hcl?
Generic versions may be available for Loperamide Hcl. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Loperamide Hcl on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Loperamide Hcl?
The cheapest pharmacy for Loperamide Hcl depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Loperamide Hcl near you.

Loperamide Hcl Coupons & Prices

Loperamide HCl 2MG

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Loperamide Hcl Capsule — prescription drug image
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Loperamide HCl (loperamide hydrochloride) is the antidiarrheal medicine best known by the brand names Imodium, Imodium A-D, and Diamode. It is sold over the counter and also by prescription, and a substitutable generic is widely available. If you use it often or need the higher prescription strength, a free loperamide-hcl coupon from Rx.com can help you compare pharmacy prices in your area. Enter your ZIP above to see today's price at pharmacies near you.

What is loperamide and how does it work?

Loperamide is an antidiarrheal medicine. It is a peripherally-acting synthetic opioid that works on mu-opioid receptors in the gut wall, slowing the movement of the intestines so that stool passes more slowly and the body reabsorbs more water. This helps firm up stools and reduce how often you go. Unlike opioids used for pain, at recommended doses loperamide acts mainly in the gut and does not produce the effects of pain-relieving opioids in the brain.

It is used to control and relieve acute nonspecific diarrhea and chronic diarrhea linked to inflammatory bowel disease, and it can reduce the volume of discharge from an ileostomy. Many travelers also keep it on hand for traveler's diarrhea.

How to save on loperamide with an Rx.com coupon

Loperamide is inexpensive as a store-brand over-the-counter product, but prices still vary from pharmacy to pharmacy, and the prescription-strength version (up to a higher daily limit under a doctor's care) is filled at the pharmacy counter. Some OTC medicines like this one can cost less with a coupon or when your provider writes a prescription for the generic.

To check, enter your ZIP code above to see today's price at pharmacies near you and show the free Rx.com coupon to the pharmacist. There is no membership or fee to use it. Because loperamide has no manufacturer copay or savings card, comparing cash and coupon prices is the most reliable way to pay less.

Loperamide vs. other antidiarrheal and gut medicines

Loperamide is one of several options for diarrhea and related digestive symptoms. Which one fits depends on your symptoms and what your provider recommends:

  • diphenoxylate/atropine — a prescription antidiarrheal that also slows the gut; it is a controlled medicine, so it is only available with a prescription.
  • bismuth subsalicylate — an over-the-counter option (the active ingredient in Pepto-Bismol and Kaopectate) used for diarrhea, upset stomach, and traveler's diarrhea.
  • dicyclomine — a prescription antispasmodic used mainly for the cramping of irritable bowel syndrome rather than to stop diarrhea itself.
  • ondansetron — a prescription medicine for nausea and vomiting, sometimes used alongside diarrhea treatment.

This is general information, not medical advice. Ask your pharmacist or provider which option is right for you.

Safety, dosing limits, and when to avoid loperamide

Take loperamide exactly as directed. Over the counter, do not exceed the labeled maximum of 8 mg per day for up to 2 days; under a prescription, a provider may direct up to 16 mg per day. Do not take more than recommended. The FDA has warned that higher-than-recommended doses can cause serious, life-threatening heart problems — including QT prolongation, a dangerous rhythm called Torsades de Pointes, other ventricular arrhythmias, fainting, and cardiac arrest, with deaths reported. These events are largely tied to abuse or misuse, such as self-treating opioid withdrawal or seeking a high. To help curb this, the FDA has limited OTC package quantities.

Do not use loperamide if constipation must be avoided, or if you have dysentery, bloody stools with a high fever, or a bacterial gut infection such as C. difficile, Salmonella, or Shigella. Avoid it if you have an abnormal heart rhythm, and use caution with medicines that inhibit P-glycoprotein, CYP3A4, or CYP2C8, because they can raise loperamide levels in the body. It is not for children under 2. Call your provider if diarrhea lasts more than 2 days or gets worse. This is not medical advice — talk with your provider or pharmacist about your situation.

Sources & accuracy

This Loperamide Hcl information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Loperamide Hcl on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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