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Imiquimod

Imiquimod 24 Cream

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What is Imiquimod?

Imiquimod treats genital warts, actinic keratoses, and basal cell carcinoma. The brand-name version of Imiquimod is called Aldara. The average Imiquimod cost is $621 for one box of 24 packets. However, you can use our free Rx.com coupon card to save significantly on Imiquimod prices at a participating pharmacy near you.

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What is Imiquimod ?

Imiquimod treats genital warts, actinic keratoses, and basal cell carcinoma. The brand-name version of Imiquimod is called Aldara. The average Imiquimod cost is $621 for one box of 24 packets. However, you can use our free Rx.com coupon card to save significantly on Imiquimod prices at a participating pharmacy near you.
  • Fever, chills, cough, sore throat, nausea, or muscle or joint pain
  • Worsening of other skin conditions
  • Severe skin reaction, including burning, pain, redness, swelling, bleeding, itching, ulcers, oozing, scabbing, blisters, or peeling
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Severe swelling near the vagina
  • Blistering, peeling red skin rash anywhere on your body
  • Tell your doctor if you are pregnant or breastfeeding, or if you have an autoimmune disorder or problems with your immune system.
  • This medicine may cause severe swelling or other skin reactions where it is applied. It could also cause flu-like symptoms. Your doctor will tell you if you need to stop using the medicine until the reaction improves.
  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
  • Topical application routeDo not use this medicine to treat a skin problem your doctor has not examined.
  • Treatment for genital warts: Do not have sex during the treatment time, even if you use protection. The cream can weaken condoms and diaphragms and they could break. Imiquimod is not a cure for genital or anal warts. You may develop new warts while using the cream. The cream will not keep you from spreading genital warts to other people.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
What is imiquimod cream used for?
Imiquimod is FDA-approved to treat actinic keratoses (scaly sun-damage growths) on the face and scalp, superficial basal cell carcinoma (a type of skin cancer) in adults with healthy immune systems, and external genital and perianal warts caused by HPV. It works by stimulating your skin's local immune system rather than removing the lesion directly.
How long does it take for imiquimod to work?
Imiquimod works over a course of treatment, not overnight. Local skin reactions like redness and flaking often appear within the first days or weeks and are a sign the cream is active. The full treatment length depends on the condition, the strength prescribed, and your response, so follow the schedule your provider gives you and do not stop early on your own.
What are the most common side effects of imiquimod?
The most common side effects are local skin reactions at the application site: redness, flaking, scaling, itching, burning, swelling, erosion, and scabbing or ulceration. It can also cause lasting skin lightening or darkening and flu-like symptoms such as fatigue, fever, muscle aches, or headache. It increases sun sensitivity, so limit sun exposure. Contact your provider if reactions become severe.
Is imiquimod (Aldara) available as a generic?
Yes. Imiquimod is available as an FDA-approved generic of Aldara, and it is typically much less expensive than the brand. Zyclara is another brand of imiquimod at different strengths. Because generic prices vary widely by pharmacy, enter your ZIP above to compare today's price and get a free discount coupon.
How often do you apply imiquimod cream?
The application frequency depends on the condition being treated and the specific product and strength prescribed, so it varies from person to person. Always follow the exact directions from your provider and the medication guide, apply it only to the areas instructed, and wash your hands afterward. Do not use it more often or longer than directed.
How much does Imiquimod cost without insurance?
The price of Imiquimod without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Imiquimod?
Common side effects of Imiquimod may include: Fever, chills, cough, sore throat, nausea, or muscle or joint pain, Worsening of other skin conditions, Severe skin reaction, including burning, pain, redness, swelling, bleeding, itching, ulcers, oozing, scabbing, blisters, or peeling, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Severe swelling near the vagina. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Imiquimod?
Generic versions may be available for Imiquimod. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Imiquimod on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Imiquimod?
The cheapest pharmacy for Imiquimod depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Imiquimod near you.

Imiquimod Coupons & Prices

Imiquimod 24 Cream

Prescriptions & Refills
Licensed US providers · Online visit in minutes
Imiquimod Box — prescription drug image
Prescription
Imiquimod 24 cream (0.5)
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Looking for an imiquimod coupon? Imiquimod is the generic version of Aldara and Zyclara, a prescription topical cream that treats certain sun-damage growths, a superficial form of skin cancer, and external genital warts. Because it is already available as a low-cost generic, most people do not need a brand-name product to save. Cash prices still vary widely from one pharmacy to the next, so comparing matters. Enter your ZIP above to see today's imiquimod price and a free discount coupon accepted at more than 60,000 pharmacies nationwide.

What is imiquimod and how does it work?

Imiquimod is an immune response modifier, a topical medicine that works by stimulating your skin's own local immune system to attack abnormal or virus-infected cells. It is sold under the brand names Aldara and Zyclara, and it is FDA-approved to treat actinic keratoses (flat, scaly growths caused by sun damage) on the face and scalp, superficial basal cell carcinoma (a type of skin cancer) in adults with healthy immune systems, and external genital and perianal warts caused by HPV. Both Zyclara strengths (2.5% and 3.75%) are approved for actinic keratosis of the full face or balding scalp, while only the 3.75% strength is also approved for external genital and perianal warts.

Rather than simply removing a lesion, imiquimod prompts the immune system to do the clearing over a course of treatment. Your dermatologist or prescriber will match the strength and schedule to your specific condition. This page is for general information and is not medical advice, so follow the instructions from your own provider.

Imiquimod cost and how to save without insurance

Imiquimod is available as an FDA-approved generic, so it is usually far less expensive than the Aldara or Zyclara brand. Even so, the cash price without insurance can differ a lot depending on which pharmacy you use, the strength prescribed, and the number of packets or the tube size. That is exactly why comparing before you fill is worth it.

Rx.com checks prices across more than 60,000 pharmacies and gives you a free discount coupon you can use whether or not you have insurance. Enter your ZIP above to see today's price near you. There is no manufacturer savings card required to get a low generic price here; if you were prescribed a specific brand, you can look up the manufacturer's official website for any current brand offers, though terms vary and eligibility rules apply.

Imiquimod alternatives and related treatments

Depending on the condition being treated, your prescriber may consider other topical options. For actinic keratoses, fluorouracil and diclofenac gel are common alternatives. For external genital warts, podofilox and sinecatechins are other topical choices. Tretinoin is sometimes used for related skin concerns.

These medicines work differently and are not interchangeable, so only your provider can decide which is right for your diagnosis. If you do compare, remember that generic prices for all of these can swing widely by pharmacy, and you can price each one on Rx.com to find the best local deal.

Safety and side effects

Imiquimod does not carry a boxed warning, but strong local skin reactions at the application site are expected and common. These can include redness, flaking, scaling, itching, burning, swelling, erosion, and scabbing or ulceration. Some people notice lasting skin lightening or darkening in the treated area. Because the cream activates the immune system, it can also cause flu-like symptoms such as fatigue, fever, muscle aches, or headache.

Imiquimod increases your skin's sensitivity to sunlight, so minimize sun exposure and avoid tanning. Do not apply it to skin that has not fully healed from a prior treatment, and keep it away from the eyes, lips, nostrils, and the inside of the vagina or anus. Use with caution if you have an autoimmune condition or a weakened immune system, and wash your hands after applying. This is general information, not medical advice; talk with your provider or pharmacist about your specific situation and any other medicines you take.

Sources & accuracy

This Imiquimod information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Imiquimod on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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