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Pentacel

Pentacel 5 Vials

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What is Pentacel?

Pentacel is a combination vaccine used to protect infants and young children against diphtheria, tetanus, pertussis (whooping cough), poliomyelitis (polio), and invasive disease due to Haemophilus influenzae type b. Administered as an intramuscular injection, Pentacel is typically given in a series of doses starting at 2 months of age, helping to ensure immunity from these serious diseases during early childhood.

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What is Pentacel ?

Pentacel is a combination vaccine used to protect infants and young children against diphtheria, tetanus, pertussis (whooping cough), poliomyelitis (polio), and invasive disease due to Haemophilus influenzae type b. Administered as an intramuscular injection, Pentacel is typically given in a series of doses starting at 2 months of age, helping to ensure immunity from these serious diseases during early childhood.
  • Lightheadedness or fainting
  • Seizures
  • Crying constantly for 3 hours or more
  • Severe headache
  • Fever over 105 degrees F
  • Severe muscle weakness or numbness
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Tell the doctor if your child has a bleeding disorder, or a history of Guillain-Barré syndrome or other severe reaction to a vaccine (including fever or prolonged crying).
  • This vaccine may increase your risk for severe nerve and muscle problems (including Guillain-Barré syndrome).
  • This vaccine will not treat an active infection. If you have a diphtheria, tetanus, or pertussis infection, you will need medicine to treat the infection.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
  • Severe headache
  • Severe muscle weakness or numbness
What is Pentacel vaccine for?
Pentacel is a combination vaccine that protects children against five diseases at once: diphtheria, tetanus, pertussis (whooping cough), polio, and invasive disease caused by Haemophilus influenzae type b (Hib). It's given to children from 6 weeks through 4 years of age as part of a 4-dose series.
What are the common side effects of Pentacel?
The Pentacel label describes reactions that providers watch for after a dose, including a fever of 40.5°C (105°F) or higher, an episode of unusual limpness, paleness, and reduced responsiveness (called a hypotonic-hyporesponsive episode), persistent crying lasting 3 hours or more, and seizures occurring within a few days of the shot. These are used to guide whether future doses need extra precautions. Ask your child's provider what to watch for and when to call after a specific dose.
What is the Pentacel vaccination schedule by age?
Pentacel is given as a 4-dose series, typically at 2 months, 4 months, 6 months, and 15-18 months of age, to children from 6 weeks through 4 years old (before their 5th birthday). It is not used for the booster dose usually given between ages 4 and 6, which relies on a different vaccine.
Is Pentacel the same as the DTaP shot?
No. Pentacel includes DTaP (diphtheria, tetanus, and acellular pertussis) as one of its components, but it also combines in inactivated poliovirus (IPV) and Haemophilus influenzae type b (Hib) protection, so a child gets five-disease protection from one combination shot instead of separate injections.
How much does Pentacel cost without insurance, and is it covered by the Vaccines for Children program?
Cost varies by provider and location since Pentacel is administered in a clinical setting rather than filled at a pharmacy counter — enter your ZIP above to compare pricing near you. Families who can't afford the vaccine may qualify for the federal Vaccines for Children (VFC) program, which provides ACIP-recommended vaccines like Pentacel at no cost to eligible children (including those who are Medicaid-eligible, uninsured, underinsured, or American Indian/Alaska Native) through participating providers.
How much does Pentacel cost without insurance?
The price of Pentacel without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 34% off retail prices with a free Rx.com coupon.
What are the common side effects of Pentacel?
Common side effects of Pentacel may include: Lightheadedness or fainting, Seizures, Crying constantly for 3 hours or more, Severe headache, Fever over 105 degrees F. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Pentacel?
Generic versions may be available for Pentacel. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Pentacel on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Pentacel?
The cheapest pharmacy for Pentacel depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Pentacel near you.

Pentacel Coupons & Prices

Pentacel 5 Vials

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If you're searching for a Pentacel coupon, here's what's useful to know upfront: Pentacel is a combination childhood vaccine given by a healthcare provider, so it doesn't work quite like a typical prescription picked up at a pharmacy counter, and its manufacturer doesn't offer a traditional retail savings card for it. Pentacel (DTaP-IPV/Hib) protects infants and young children against diphtheria, tetanus, pertussis, polio, and invasive Haemophilus influenzae type b disease as part of a four-dose series, and families without coverage may qualify for the federal Vaccines for Children program at no cost. Enter your ZIP above to see today's price and compare what nearby pharmacies and clinics that offer vaccination services charge.

What Is Pentacel and How Does It Work?

Pentacel is a combination vaccine that protects against five diseases in a single series of shots: diphtheria, tetanus, pertussis (whooping cough), poliomyelitis, and invasive disease caused by Haemophilus influenzae type b (Hib). It's FDA-licensed for children 6 weeks through 4 years of age (before the 5th birthday), given as a 4-dose series typically administered at 2, 4, 6, and 15-18 months.

Pentacel is supplied as a two-component kit: a liquid DTaP-IPV solution is used to reconstitute a freeze-dried (lyophilized) Hib component just before the shot is given by injection into a muscle. Because it must be mixed and administered by a trained healthcare provider, it's given in a clinical setting rather than dispensed for self-administration at home.

Manufacturer Savings Card vs. the Rx.com Cash Price

Unlike many brand-name prescription drugs, Pentacel's manufacturer, Sanofi, does not offer a traditional retail copay savings card for it, since Pentacel isn't filled at a pharmacy counter with a prescription — it's administered by a doctor, clinic, or pharmacy immunizer as part of a well-child visit. There is also no generic version of Pentacel, since it's a biological combination vaccine rather than a small-molecule drug that can be copied by a generic manufacturer.

If you're uninsured, underinsured, or your insurance doesn't fully cover the visit, ask your child's provider whether they qualify for the federal Vaccines for Children (VFC) program, which supplies ACIP-recommended vaccines like Pentacel at no cost to eligible children through participating providers. Enter your ZIP above to compare cash pricing at pharmacies and clinics near you that offer childhood immunizations.

Pentacel vs. Other Childhood Vaccines

Several other vaccines cover some or all of the same diseases as Pentacel, and your child's provider may offer a different combination depending on what's in stock or your child's specific needs. Vaxelis is a hexavalent combination that adds hepatitis B protection to the same diphtheria-tetanus-pertussis-polio-Hib coverage. Pediarix combines DTaP, polio, and hepatitis B (but not Hib) and is used for a different dosing schedule. Infanrix is a standalone DTaP vaccine, Hiberix is a standalone Hib vaccine, and Ipol is a standalone inactivated poliovirus vaccine — any of these can be used to build a custom schedule instead of a combination product.

Ask your child's pediatrician which combination fits your child's age, vaccination history, and any doses already received, since switching between products mid-series has its own guidelines.

Safety Information

Pentacel does not carry an FDA boxed warning. It should not be given to a child with a history of a severe, life-threatening allergic reaction to a previous dose or to any vaccine component, a history of encephalopathy within 7 days of a prior pertussis-containing vaccine not explained by another cause, or an unstabilized progressive neurologic disorder.

Providers use extra caution in children who, after a prior dose, had a fever of 40.5°C (105°F) or higher, a hypotonic-hyporesponsive episode (a temporary limp, pale, less-responsive state), persistent crying lasting 3 hours or more, or a seizure within 3 days of vaccination. Guillain-Barré syndrome has been reported in temporal association with tetanus-containing vaccines, and infants born very prematurely may be at higher risk of apnea after injection. This is general information, not medical advice — talk with your child's pediatrician about their specific health history before any vaccination.

Sources & accuracy

This Pentacel information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Pentacel on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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