Repatha
Repatha
What is Repatha?
Repatha (evolocumab) is a medication used primarily to treat high cholesterol levels in patients who are at high risk of cardiovascular disease, or who cannot tolerate other cholesterol-lowering medications. It is a monoclonal antibody that works by inhibiting proprotein convertase subtilisin/kexin type 9 (PCSK9), a protein that degrades receptors responsible for removing LDL cholesterol from the bloodstream, thereby lowering LDL cholesterol levels. Repatha is administered via subcutaneous injection.
Side Effects
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Warnings
- Tell your doctor if you are pregnant or breastfeeding, or if you have a latex allergy.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Prescription savings · · · ·
What is Repatha ?
Repatha (evolocumab) is a medication used primarily to treat high cholesterol levels in patients who are at high risk of cardiovascular disease, or who cannot tolerate other cholesterol-lowering medications. It is a monoclonal antibody that works by inhibiting proprotein convertase subtilisin/kexin type 9 (PCSK9), a protein that degrades receptors responsible for removing LDL cholesterol from the bloodstream, thereby lowering LDL cholesterol levels. Repatha is administered via subcutaneous injection.
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Tell your doctor if you are pregnant or breastfeeding, or if you have a latex allergy.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Repatha Coupons & Prices
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Looking for a Repatha coupon? Rx.com offers a free cash-price coupon you can use at the pharmacy counter for Repatha (evolocumab), a brand-name PCSK9 inhibitor injection that lowers LDL ("bad") cholesterol. There is no generic version yet, so price differences between pharmacies can be large. Enter your ZIP above to see today's Repatha price near you and print or text yourself the coupon at no cost.
What is Repatha and how does it work?
Repatha (evolocumab) is a lipid-lowering biologic given as a subcutaneous (under-the-skin) injection. It is a human monoclonal antibody in a class called PCSK9 inhibitors. By blocking the PCSK9 protein, it helps the liver clear more LDL ("bad") cholesterol from the blood. It is supplied as a prefilled single-dose Repatha SureClick autoinjector.
Repatha is FDA-approved to reduce LDL cholesterol and, in adults with established cardiovascular disease, to lower the risk of heart attack, stroke, and coronary revascularization. It is used as an add-on to diet, either alone or with other lipid-lowering therapies such as statins, for adults with primary hyperlipidemia (including heterozygous familial hypercholesterolemia, or HeFH) and for children 10 and older with HeFH. It is also used as an add-on to other LDL-lowering therapies for adults and children 10 and older with homozygous familial hypercholesterolemia (HoFH). Its safety and effectiveness have not been established in children under 10 or in children with other types of hyperlipidemia.
Manufacturer savings card vs. Rx.com cash coupon
Amgen, the maker of Repatha, runs an official copay savings card program (described on the manufacturer's Repatha website) that can lower out-of-pocket costs for eligible patients. Like most brand copay cards, it is generally limited to people with commercial (private) insurance and excludes those with government coverage such as Medicare, Medicaid, or TRICARE. Terms, eligibility, and any caps vary and change over time, so check the current rules before you rely on it.
The Rx.com cash coupon works differently: it is a cash-price discount, not insurance. That makes it useful if you are uninsured, if you have Medicare or another plan the copay card does not accept, or if the manufacturer card is declined. You cannot combine a cash coupon with insurance on the same purchase, so it pays to compare both. Amgen also offers a patient-assistance pathway through the Repatha enrollment/support program for those who qualify. Enter your ZIP above to see today's cash price at pharmacies near you.
Repatha alternatives and how they compare
Because Repatha has no generic, some people ask their prescriber about other cholesterol-lowering options. A few to discuss:
- Praluent (alirocumab) - another injectable PCSK9 inhibitor, similar to Repatha.
- Leqvio (inclisiran) - a twice-yearly injection that also targets PCSK9 through a different mechanism.
- atorvastatin and rosuvastatin - widely used statin pills that are available as low-cost generics.
- ezetimibe - an oral, generically available option often added to a statin.
These medicines are not interchangeable and are approved for different situations. Only your provider can decide what is right for you.
Repatha safety and side effects
Repatha has no boxed warning. It should not be used by anyone with a history of a serious hypersensitivity (allergic) reaction to evolocumab. Hypersensitivity reactions, including angioedema and rash, have been reported; if a serious reaction occurs, treatment should be stopped. The most common side effects are injection-site reactions, a stuffy or runny nose or upper respiratory infection, flu, and back pain. Patients with a latex allergy should note that the needle cover of the SureClick autoinjector may contain dry natural rubber.
This is general information, not medical advice. Talk with your doctor or pharmacist about your full medical history and any reactions before starting or changing Repatha.
This Repatha information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Repatha on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.