Ezetimibe Coupons & Prices

Looking for an ezetimibe coupon? Ezetimibe is the low-cost generic version of Zetia, a cholesterol-lowering medicine that reduces LDL ("bad") cholesterol. Because it is already available as a generic, cash prices are usually modest, but they still vary widely from one pharmacy to the next, so it pays to compare. Enter your ZIP above to see today's price at pharmacies near you. Rx.com checks prices across more than 60,000 pharmacies so you can find a low price without insurance and use a free discount coupon at the counter.

What is ezetimibe and how does it work?

Ezetimibe is a cholesterol absorption inhibitor. Unlike statins, which act in the liver, ezetimibe works in the small intestine, where it blocks the absorption of cholesterol from the food you eat. The result is lower LDL, or "bad," cholesterol in the blood. It is FDA-approved to treat primary hyperlipidemia and mixed hyperlipidemia, either on its own or together with a statin. Combined with the statin atorvastatin or simvastatin, it is also used for homozygous familial hypercholesterolemia (HoFH). Separately, ezetimibe on its own is approved as an add-on to diet for a rare inherited condition called homozygous sitosterolemia (phytosterolemia), where it helps lower elevated plant-sterol (sitosterol and campesterol) levels.

Doctors often add ezetimibe to a statin when the statin alone does not bring LDL cholesterol down to goal, and it is a common option for people who cannot tolerate higher statin doses. It is taken as a once-daily tablet.

How much does ezetimibe cost without insurance?

Ezetimibe is a generic drug, so it is generally one of the more affordable cholesterol medicines, especially compared with the brand-name Zetia. Even so, the cash price can differ a lot depending on which pharmacy you use, since each pharmacy sets its own price. That is exactly why comparing is worth the effort.

Rx.com compares live ezetimibe prices across more than 60,000 U.S. pharmacies and provides a free discount coupon you can show at the pharmacy counter, with or without insurance. There is no membership fee to use it. Enter your ZIP code above to see today's price near you and the coupon that goes with it.

Ezetimibe alternatives and related medicines

Ezetimibe is sold under the brand name Zetia and appears in several combination products, so you may see it paired with other cholesterol drugs:

• Vytorin and its generic ezetimibe-simvastatin combine ezetimibe with simvastatin.
• Combination products also pair ezetimibe with bempedoic acid (Nexlizet) and with rosuvastatin (Roszet).

Statins such as atorvastatin, rosuvastatin, and simvastatin are frequently prescribed alongside or instead of ezetimibe. Your provider will choose the option that best fits your cholesterol goals and how well you tolerate each medicine. You can compare cash prices on any of these on Rx.com.

Ezetimibe safety and side effects

Taken by itself, ezetimibe has no boxed warning. When it is combined with a statin, it should not be used by people with active liver disease or unexplained, persistent elevations in liver enzymes. Like statins, the combination can rarely cause muscle problems (myopathy or, very rarely, rhabdomyolysis), so tell your provider right away about any unexplained muscle pain, tenderness, or weakness. Other uncommon effects include liver enzyme elevations, pancreatitis, gallstones, and allergic reactions such as rash or swelling (angioedema).

Ezetimibe is generally not recommended during pregnancy or breastfeeding when it is taken together with a statin. This information is educational and is not a substitute for medical advice. Talk with your doctor or pharmacist about your full medical history and any other medicines you take before starting or changing ezetimibe.