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Sodium Valproate

Sodium Valproate 100GM of

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What is Sodium Valproate?

Sodium valproate is an anticonvulsant medication used primarily to treat epilepsy and bipolar disorder. It works by stabilizing electrical activity in the brain and preventing sudden electrical charges that cause seizures and mood swings. Sodium valproate is administered orally or intravenously and may be used alone or in combination with other medications.

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What is Sodium Valproate ?

Sodium valproate is an anticonvulsant medication used primarily to treat epilepsy and bipolar disorder. It works by stabilizing electrical activity in the brain and preventing sudden electrical charges that cause seizures and mood swings. Sodium valproate is administered orally or intravenously and may be used alone or in combination with other medications.
  • Nausea
  • Vomiting
  • Dizziness
  • Tremor
  • Hair loss
  • Weight gain
  • Abdominal pain
  • Blurred vision
  • Confusion
  • Thrombocytopenia (low platelet count)
  • Liver damage - monitoring liver function is important, especially during the first six months of treatment.
  • Pancreatitis - can occur in patients taking sodium valproate, sometimes fatal.
  • Teratogenic effects - can cause significant congenital malformations and cognitive impairment in children born to women who took valproate during pregnancy.
  • Hyperammonemia - elevated ammonia levels can occur and may present as lethargy or changes in mental state.
  • Suicidal thoughts and behaviors - monitor for worsening depression or suicidal thoughts and behaviors.
  • Drug interactions - valproate can interact with many other medications, potentially increasing side effects or decreasing effectiveness.
  • Elderly - use cautiously in the elderly, as they may be more sensitive to side effects.
  • Bleeding and clotting disorders - may affect platelet count and coagulation parameters.
  • Hypothermia - sodium valproate has been associated with hypothermia, which may require clinical intervention.
What is sodium valproate used for?
Sodium valproate and related valproate products are FDA-approved to treat certain types of seizures (including complex partial seizures and absence seizures, alone or added to other seizure medicines), to treat manic episodes of bipolar disorder, and to prevent migraine headaches. It's sometimes used off-label for other purposes, such as an IV form for a seizure emergency, but those are not its primary approved uses.
What is the difference between sodium valproate, valproic acid, and divalproex sodium (Depakote)?
All three contain the same active molecule but in different chemical forms. Sodium valproate is the sodium salt (used in the IV brand Depacon), valproic acid is the free-acid form (the brand Depakene), and divalproex sodium (Depakote/Depakote ER) is a combination of the two that converts to valproic acid once you swallow it. They aren't automatically interchangeable dose-for-dose, so always take the specific product and strength your doctor prescribed.
What are the signs of liver damage from valproate?
Valproate carries a boxed warning for liver failure that can be fatal, with the highest risk in the first six months of treatment and in young children. Contact your doctor right away if you notice yellowing of the skin or eyes, dark urine, unusual fatigue or weakness, loss of appetite, nausea or vomiting, or abdominal pain — these can be early signs of liver problems.
Can you take sodium valproate while pregnant?
Valproate carries a boxed warning for fetal risk: it can cause neural tube defects and other major birth defects, and children exposed during pregnancy have shown lower IQ and neurodevelopmental problems. It should not be used for migraine prevention during pregnancy, and for epilepsy or bipolar disorder it should only be used in pregnancy if no other treatment is effective. Anyone who is pregnant or could become pregnant should talk with their doctor before starting or continuing valproate.
How long does it take for sodium valproate to work for seizures or bipolar disorder?
This depends on the condition, the dose, and the individual, and it's best answered by your prescribing doctor based on your specific treatment plan and how your body responds. The grounded facts for this page don't include a specific onset timeline, so ask your doctor or pharmacist what to expect for your situation.
How much does Sodium Valproate cost without insurance?
The price of Sodium Valproate without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Sodium Valproate?
Common side effects of Sodium Valproate may include: Nausea, Vomiting, Dizziness, Tremor, Hair loss. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Sodium Valproate?
Generic versions may be available for Sodium Valproate. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Sodium Valproate on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Sodium Valproate?
The cheapest pharmacy for Sodium Valproate depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Sodium Valproate near you.

Sodium Valproate Coupons & Prices

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Looking for a sodium valproate coupon? Sodium valproate (valproate sodium, closely related to valproic acid and divalproex sodium) is available as a generic, but the price still isn't the same at every pharmacy. Rx.com compares prices for sodium valproate across more than 60,000 U.S. pharmacies, so instead of guessing, enter your ZIP above to see today's price at pharmacies near you.

What Is Sodium Valproate?

Sodium valproate (valproate sodium) is an anticonvulsant, also called an antiepileptic, that is also used as a mood stabilizer. It's the active ingredient in the injectable brand Depacon and is closely related to valproic acid (the brand Depakene) and divalproex sodium (the brand Depakote/Depakote ER), which the body converts into valproic acid; all three are grouped together as "valproate" medications and work the same way once in the bloodstream.

Valproate products are FDA-approved for monotherapy and adjunctive (add-on) treatment of complex partial seizures and simple or complex absence seizures, for adjunctive treatment in people with multiple seizure types including absence seizures, for treating manic episodes of bipolar disorder, and for preventing migraine headaches. Doctors also sometimes prescribe it off-label, such as an IV form for status epilepticus (a seizure emergency) or, less commonly, for agitation in dementia or for ADHD in children — these are off-label uses your doctor would need to explain and are not the drug's main, FDA-approved purpose.

Sodium Valproate Cost and Coupons

Sodium valproate is available as a generic, and it does not have a manufacturer savings card the way many brand-name drugs do — those cards are typically only offered on brand products. That doesn't mean the price is the same everywhere, though. Generic drug prices can vary significantly from one pharmacy to the next, sometimes even between two pharmacies in the same neighborhood, so it's worth comparing before you fill.

Rx.com checks pricing at over 60,000 pharmacies nationwide, including major chains and independent pharmacies, so you can see where your specific prescription (strength, quantity, and pharmacy) is priced lowest. Enter your ZIP code and prescription details above to compare current prices near you.

Sodium Valproate vs. Valproic Acid vs. Divalproex Sodium (Depakote)

Patients are often confused about the difference between sodium valproate, valproic acid, and divalproex sodium because a pharmacist may fill any of the three depending on what your doctor prescribed. Sodium valproate is the sodium salt form (used in the IV brand Depacon); valproic acid is the free-acid form (the brand Depakene); and divalproex sodium (Depakote/Depakote ER) is a compound that combines valproic acid and sodium valproate in a 1:1 ratio and breaks down into valproic acid in the digestive tract. Because the forms aren't interchangeable milligram-for-milligram, your doctor and pharmacist choose the specific product and dose — don't switch between them without medical guidance.

If you and your doctor are weighing other seizure or bipolar medication options, related anticonvulsants include lamotrigine, levetiracetam, carbamazepine, and topiramate. Each has its own uses, dosing, and side-effect profile, so a switch should always be discussed with your prescriber.

Sodium Valproate Safety Information

Sodium valproate carries boxed warnings, the FDA's strongest safety warning, for three serious risks. First, hepatotoxicity: it can cause liver failure that has been fatal, with the highest risk in the first six months of treatment and in children under age 2; it should not be used in people with known mitochondrial disorders such as Alpers-Huttenlocher syndrome (POLG mutations). Second, fetal risk: valproate can cause neural tube defects and other major birth defects, and children exposed in the womb have shown decreased IQ and neurodevelopmental problems — it should not be used for migraine prevention during pregnancy, and in epilepsy or bipolar disorder it should only be used in pregnancy if no other treatment works for you. Third, pancreatitis: this can be fatal and can occur at any point during treatment, not just early on.

Valproate also carries a warning shared across anticonvulsant medications about a small increased risk of suicidal thoughts or behavior, and it should not be used by anyone with a known urea cycle disorder. Watch for and report symptoms like unusual bleeding, severe abdominal pain, yellowing skin or eyes, or unusual fatigue to your doctor right away. This is general information, not medical advice — talk with your doctor or pharmacist about whether sodium valproate is right for you.

Sources & accuracy

This Sodium Valproate information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Sodium Valproate on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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