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Valsartan-Hydrochlorothiazide Tablet — prescription drug image

Valsartan-Hydrochlorothiazide

Valsartan-hydroCHLOROthiazide 320-25MG

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What is Valsartan-Hydrochlorothiazide?

Valsartan-hydrochlorothiazide is a prescription medication used to treat high blood pressure (hypertension). This combination drug helps relax blood vessels and reduces fluid retention, making it easier for the heart to pump blood. Connect with a licensed provider through Rx.com for more information on costs, savings, and prescription options.

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What is Valsartan-Hydrochlorothiazide ?

Valsartan-hydrochlorothiazide is a prescription medication used to treat high blood pressure (hypertension). This combination drug helps relax blood vessels and reduces fluid retention, making it easier for the heart to pump blood. Connect with a licensed provider through Rx.com for more information on costs, savings, and prescription options.
  • Confusion, weakness, uneven heartbeat, trouble breathing, numbness in your hands, feet, or legs
  • Lightheadedness, dizziness, fainting
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Blistering, peeling, red skin rash
  • Dry mouth, increased thirst, muscle cramps, nausea, vomiting
  • Eye pain, vision changes, seeing halos around lights
  • Change in how much or how often you urinate, bloody or cloudy urine
  • Sores, reddish patch or irritated area, shiny bump, pink growth, or white, yellow or waxy scar-like area on the skin
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Drink plenty of fluids if you exercise, sweat more than usual, or have diarrhea or vomiting while you are using this medicine.
  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
  • This medicine could lower your blood pressure too much, especially when you first use it or you are dehydrated. Stand or sit up slowly if you feel dizzy or lightheaded.
  • This medicine may cause the following problems:Kidney problemsEye or vision problems, including glaucoma, myopiaChanges in blood sugar levelsHigh cholesterol, fats, or uric acid in the bloodIncreased risk of skin cancer
  • Tell your doctor if you are breastfeeding, or if you have kidney problems, heart or blood vessel problems, heart failure, diabetes, gout, high cholesterol, lupus, trouble urinating, or a history of asthma or allergies.
  • This medicine is not safe to take during pregnancy, especially in your second or third trimester. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
What is valsartan and hydrochlorothiazide used for?
It is FDA-approved to treat high blood pressure, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, mainly strokes and heart attacks. The label says it may be used when blood pressure is not adequately controlled on a single medicine, and that it may also be used as initial therapy in people likely to need more than one drug to reach their goal. It is also used as a replacement for people already stable on valsartan and hydrochlorothiazide as separate pills. One exception in the label: it is not recommended as initial therapy in people with intravascular volume depletion. Valsartan alone has additional approvals for heart failure and for left ventricular dysfunction after a heart attack, but this combination tablet is not approved for those uses.
Is valsartan-hydrochlorothiazide the same as Diovan HCT?
Yes. Diovan HCT is the Novartis brand name, and valsartan-hydrochlorothiazide is the generic version of the same combination. FDA-approved generics are on the market, so your pharmacy will usually fill the generic unless your prescriber specifies the brand. Whether a pharmacist can substitute automatically depends on your state's law and the generic's FDA rating, so ask if you have questions. Do not confuse it with Exforge HCT, which is a different product that also contains amlodipine.
What are the most common side effects of valsartan-hydrochlorothiazide?
Because it contains a diuretic, it can affect your body's salt and mineral balance, including low potassium, low sodium, low magnesium, high calcium, and higher uric acid that can bring on gout. Valsartan can raise potassium instead, which is why your doctor may check bloodwork. Blood pressure can drop too low, especially if you are dehydrated or low on salt. Kidney function can also be affected. Less common but important: sudden vision changes or eye pain within hours to weeks of starting can signal acute angle-closure glaucoma and needs prompt medical attention. Ask your pharmacist for the full list and tell your doctor about anything that bothers you.
Should you take valsartan-hydrochlorothiazide in the morning or at night?
Follow the schedule your prescriber and the label on your bottle give you. Because it contains a water pill, many people prefer taking it in the morning so they are not up overnight going to the bathroom, but that is a practical preference, not a rule from the FDA label. The most important thing is taking it at the same time every day. If you want to change your timing, ask your pharmacist or doctor first.
Can you drink alcohol while taking valsartan and hydrochlorothiazide?
Talk to your doctor about alcohol. Alcohol can lower blood pressure further and contribute to dehydration, and this medicine already lowers blood pressure and removes fluid, so the combination may make you feel dizzy or lightheaded, especially when standing up. There is no single safe amount that applies to everyone. Your prescriber can advise based on your dose, kidney function, and other medicines.
How long does it take for valsartan and hydrochlorothiazide to lower blood pressure?
Blood pressure medicines generally take some time to reach their full effect, and your doctor will usually recheck your readings after a few weeks before deciding whether the dose is right. You will not feel high blood pressure being treated, so do not judge it by how you feel. Keep taking it as prescribed even when you feel fine, and do not stop without talking to your prescriber.
How much does Valsartan-Hydrochlorothiazide cost without insurance?
The price of Valsartan-Hydrochlorothiazide without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Valsartan-Hydrochlorothiazide?
Common side effects of Valsartan-Hydrochlorothiazide may include: Confusion, weakness, uneven heartbeat, trouble breathing, numbness in your hands, feet, or legs, Lightheadedness, dizziness, fainting, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Rapid weight gain, swelling in your hands, ankles, or feet, Blistering, peeling, red skin rash. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Valsartan-Hydrochlorothiazide?
Generic versions may be available for Valsartan-Hydrochlorothiazide. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Valsartan-Hydrochlorothiazide on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Valsartan-Hydrochlorothiazide?
The cheapest pharmacy for Valsartan-Hydrochlorothiazide depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Valsartan-Hydrochlorothiazide near you.

Valsartan-Hydrochlorothiazide Coupons & Prices

Valsartan-hydroCHLOROthiazide 320-25MG

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Valsartan-Hydrochlorothiazide Tablet — prescription drug image
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Valsartan-Hydrochlorothiazide 160-12.5mg (7)
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Valsartan-Hydrochlorothiazide prices by dosage

Lowest cash price with a free Rx.com coupon vs. the average retail price.

Dosage Quantity Retail price Rx.com price
80-12.5mg · Tablet 30 $59.99 $12.03
160-12.5mg · Tablet 30 $111.19 $9.00
160-25mg · Tablet 30 $133.19 $9.00
320-25mg · Tablet 30 $169.59 $17.13
320-12.5mg · Tablet 30 $60.32 $14.01

Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.

Looking for a valsartan-hydrochlorothiazide coupon? Rx.com compares cash prices at more than 60,000 pharmacies so you can see what this blood pressure combination costs near you today. Valsartan and hydrochlorothiazide is the generic version of Diovan HCT, and FDA-approved generics of this combination are on the market. What surprises most people is how much the cash price can differ from one pharmacy to the next, even across the street. Enter your ZIP above to see today's price and print or show the free coupon at the counter.

What is valsartan and hydrochlorothiazide, and how does it work?

Valsartan and hydrochlorothiazide is a single tablet that combines two blood pressure medicines. Valsartan is an angiotensin II receptor blocker (an ARB), which relaxes blood vessels so blood flows more easily. Hydrochlorothiazide is a thiazide diuretic, or "water pill," which helps your kidneys remove extra salt and fluid. Together they lower blood pressure more than either one alone. The brand name version is Diovan HCT, made by Novartis.

It is FDA-approved to treat high blood pressure (hypertension), to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, mainly strokes and heart attacks. According to the label, it may be used in people whose blood pressure is not adequately controlled on a single medicine, and it may also be used as initial therapy in people who are likely to need more than one drug to reach their blood pressure goal. It is also prescribed as a replacement for people already taking valsartan and hydrochlorothiazide as separate pills. The label does note one narrow exception: it is not recommended as initial therapy in people with intravascular volume depletion. Note that valsartan by itself has additional approvals for heart failure and for left ventricular problems after a heart attack. This combination tablet is not approved for those uses.

What valsartan-hydrochlorothiazide costs without insurance

An FDA-approved generic of this exact combination is on the market, so most people fill the generic. Whether your pharmacy can swap the generic for a brand prescription depends on the generic's rating and on your state's substitution law, so ask your pharmacist. Cash prices are also not standardized. Pharmacies set their own retail prices, and the same prescription can cost noticeably different amounts at two stores in the same town. That is exactly why comparing before you fill is worth the minute it takes.

Rx.com's free coupon works at more than 60,000 pharmacies nationwide and requires no membership or sign-up. Enter your ZIP above to see today's price near you. If you are prescribed the brand Diovan or Diovan HCT specifically, check the manufacturer's official site for any current copay or patient-support program. Programs like these change or end without notice, and they typically exclude people with government insurance such as Medicare or Medicaid. A coupon cannot be combined with insurance, so compare the cash price against your copay and use whichever is lower.

Alternatives and similar combination blood pressure pills

If this combination is not the right fit, or if the price at your pharmacy is high, several other ARB or ACE inhibitor plus diuretic combinations are available as generics. Your prescriber decides which is appropriate. Common ones to ask about include:

You can also price the two ingredients separately, since valsartan and hydrochlorothiazide are each sold as standalone generics. Sometimes two prescriptions cost less than one combination tablet, and sometimes the reverse is true. Never switch on your own. Ask your prescriber first, because dosing has to match.

Safety information you should know

Valsartan and hydrochlorothiazide carries an FDA boxed warning for fetal toxicity. Medicines that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. When pregnancy is detected, the medicine should be discontinued as soon as possible, so tell your doctor right away if you become pregnant or think you might be. It is also not for use while breastfeeding.

Other things to discuss with your provider: low blood pressure can occur if you are dehydrated or low on salt, so that should be corrected first, and this is also why the medicine is not recommended as a starting treatment in people who are volume depleted; kidney function can worsen, particularly with narrowed kidney arteries or heart failure; valsartan can raise potassium, so be careful with potassium supplements, potassium-sparing diuretics, and salt substitutes; hydrochlorothiazide can lower potassium, sodium, and magnesium, and can raise calcium and uric acid, which may trigger gout. Hydrochlorothiazide has also been linked to sudden blurred or nearsighted vision and acute angle-closure glaucoma, usually within hours to weeks of starting, which needs prompt medical attention, and to a higher risk of non-melanoma skin cancer with long-term use, so use sun protection and get skin checks. It may worsen lupus. Avoid combining with aliskiren if you have diabetes, and avoid pairing with an ACE inhibitor. NSAIDs such as ibuprofen can blunt the blood pressure benefit and stress the kidneys. This page is information only, not medical advice. Talk with your doctor or pharmacist about your own situation.

Sources & accuracy

This Valsartan-Hydrochlorothiazide information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Valsartan-Hydrochlorothiazide on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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