How Much Does MOTS-c Cost? Prescription Prices in 2026
What prescription MOTS-c costs at Rx.com during the Black Friday sale, what any MOTS-c price should cover, and why a cheap "research" vial is not the same product.
At Rx.com, prescription MOTS-c costs $199 month to month, or $597 for 6 months during the Black Friday sale ($99.50 a month). The sale is "buy 3 months, get 3 free" and runs through Friday, November 27, 2026; prices after November 27 may change. That price is for MOTS-c compounded by a licensed U.S. 503A pharmacy after a U.S.-licensed provider reviews your intake, and you are billed only if you are prescribed it.
- MOTS-c month to month: $199.
- MOTS-c 6-month plan: $597 one payment ($99.50 a month, about $3.30 a day).
- All 6 months must be shipped within 6 months of purchase. Unclaimed months expire.
- No code needed. The sale price is the price shown at checkout.
- Billed only if a provider prescribes it. Not available in Louisiana or Mississippi.
- MOTS-c is not FDA approved. Evidence is mostly from mice and cells.
Black Friday saleEnds Fri, Nov 27
Buy 3 months, get 3 free
6 months of prescription MOTS-c for $597 ($99.50/mo), or $199 month to month. Prescribed by a U.S.-licensed provider, compounded by a licensed U.S. 503A pharmacy. No code needed, billed only if prescribed. Not FDA approved.
Prescription MOTS-c from Rx.com, from $99.50/mo. Online visit with a U.S.-licensed provider, compounded by a licensed U.S. 503A pharmacy. Not FDA approved.
See plans →See if MOTS-c is right for you: 6 months for $597
MOTS-c price at Rx.com
Here is exactly what prescription MOTS-c costs at Rx.com right now. The same prices apply to BPC-157 and Epitalon.
| Plan | You pay | Per month | Per day (about) |
|---|---|---|---|
| Month to month | $199 | $199 | $6.60 |
| 6-month plan (Black Friday: buy 3, get 3 free) | $597 once | $99.50 | $3.30 |
| 6 months bought one at a time | $1,194 | $199 | $6.60 |
The 6-month plan saves $597 compared with paying month to month for 6 months. It costs the same as 3 monthly orders, so it pays off if you use 4 months or more.
Two rules matter. First, the 6-month plan is one payment up front, and all 6 months must be shipped within 6 months of purchase; unclaimed months expire. Second, these are sale prices through Friday, November 27, 2026. Prices after November 27 may change. For the full side-by-side, read 6-month vs month-to-month peptide plan.
What MOTS-c is, and what it is studied for
MOTS-c is a small peptide that your body makes naturally. It is coded by DNA inside the mitochondria, the parts of your cells that turn food into energy. That is why it is called a mitochondrial-derived peptide.
Most of what we know comes from animals and cells:
- In mice, MOTS-c has been studied for insulin sensitivity, weight gain on a high-fat diet, and exercise capacity.
- In people, studies mostly measure natural MOTS-c levels in the blood (for example, before and after exercise). They do not test MOTS-c as a treatment.
So be clear-eyed: early research is interesting, but there are no large human trials showing what MOTS-c does as a treatment. It is not FDA approved. A provider can help you decide whether it makes sense for you, and they may say no. For side effects and safety, see MOTS-c side effects and safety.
What a MOTS-c price should include
Comparing MOTS-c prices only works if you compare the same thing. Before you look at the number, check what is behind it:
| Ask | Why it matters | Rx.com |
|---|---|---|
| Does a licensed provider review my health? | Someone should check your medicines (especially diabetes medicine) and history before you start | Yes, a U.S.-licensed provider reviews your online intake |
| Which pharmacy makes it? | Only licensed 503A pharmacies are covered by the 2026 FDA policy | A licensed, state-inspected U.S. 503A pharmacy |
| Is it a single ingredient? | Blends make it hard to know what you are taking | Yes, MOTS-c only |
| Is it labeled for me? | A prescription label lists your name and your dose | Yes |
| Am I charged before approval? | You should not pay for medicine you are not prescribed | No, billed only if prescribed |
| Is there a code or fine print on the price? | Hidden codes and add-ons make prices hard to compare | No code; the sale price shows at checkout |
Elsewhere, ask whether the price covers the provider visit, whether lab work or a membership is extra, and whether shipping is added. A lower sticker price can end up costing more.
Research vials vs prescription MOTS-c
If you search for MOTS-c prices, you will find vials sold as "research peptides" for less than a prescription. They are not a cheaper version of the same thing.
| "Research use only" vial | Prescription MOTS-c | |
|---|---|---|
| Prescription | None | From a U.S.-licensed provider |
| Who makes it | Often unknown | Licensed 503A compounding pharmacy |
| Label | "Not for human consumption" | Your name and your dose |
| Covered by the 2026 FDA policy | No | Yes, when the conditions are met |
| Health review | None | Yes |
A vial labeled "not for human consumption" means no one has checked whether it is right for you, and no pharmacy stands behind what is in it. The FDA policy does not cover those products. Our peptide buying checklist and where to get peptides legally explain what to look for. If a Black Friday "deal" looks too good, read peptide Black Friday scam red flags.
Insurance and other costs
Because compounded MOTS-c is not FDA approved, health insurance usually does not cover it. Plan on paying cash. If you use an HSA or FSA, ask your plan administrator whether it qualifies.
Other things to budget for:
- Time on treatment. If you expect to stay on MOTS-c for several months, the 6-month plan is the lower monthly cost.
- Check-ins. Your provider may want to hear how you are doing, especially if you take medicine that affects blood sugar.
- Price changes. Prices after November 27 may change, so the Black Friday price is the one you can count on today.
Is prescription MOTS-c legal?
MOTS-c is not FDA approved. On October 28, 2026, the FDA and HHS issued an interim enforcement-discretion policy. It lets licensed 503A pharmacies and physicians compound six peptides (BPC-157, TB-500, KPV, MOTS-c, Semax and Epitalon) for individual patients with a prescription, if they meet quality, labeling and safety-reporting conditions.
That is not approval. It is temporary, it can change, and states may set their own rules. "Research use only" products are outside the policy. TB-500, KPV and Semax are not offered by Rx.com. More detail: are peptides legal in the U.S.?
Who should talk to a provider first
Tell your provider, and expect a careful review, if any of these apply to you:
- You take diabetes medicine, such as insulin or pills that lower blood sugar. MOTS-c has been studied for effects on blood sugar in mice, so your provider needs to know.
- You are pregnant or breastfeeding, or planning to be.
- You have cancer or a history of cancer. There are open questions about peptides and growth signals.
- You are under 18.
Getting MOTS-c through Rx.com
Rx.com sells three prescription compounded peptides: BPC-157, MOTS-c and Epitalon. Each is a single-ingredient injection given under the skin. Here is how ordering MOTS-c works:
- Fill out an online intake about your health and medicines.
- A U.S.-licensed provider reviews it and decides whether MOTS-c is right for you. They may say no.
- If prescribed, a licensed, state-inspected U.S. 503A pharmacy compounds MOTS-c for you, labeled with your name. Your pharmacy label lists your dose.
- You are billed only if prescribed.
Black Friday sale through Friday, November 27, 2026: buy 3 months, get 3 free. 6 months of MOTS-c for $597 ($99.50 a month), or $199 month to month. All 6 months must be shipped within 6 months of purchase; unclaimed months expire. No code to enter. Prices after November 27 may change. Not available in Louisiana or Mississippi.
Lock in 6 months of MOTS-c for $597
Prefer one month at a time? Start MOTS-c month to month for $199. You can also compare MOTS-c plans, read the MOTS-c Black Friday deal, or see all prescription peptides and the Black Friday peptide deals guide.
🚨 When to Contact Your Healthcare Provider
Call your provider if any of these happen while you use MOTS-c. Call 911 for trouble breathing, fainting or chest pain.
- Shakiness, sweating, confusion, hunger or a fast heartbeat: possible low blood sugar, especially if you take diabetes medicine.
- Redness, heat, swelling or pus at the injection site, or a fever: possible infection.
- Hives, itching all over, or swelling of the face, lips or throat: possible allergic reaction.
- A new lump, or a cancer diagnosis while on MOTS-c.
- You become pregnant.
- You think you took too much: call Poison Control at 1-800-222-1222.
Black Friday saleEnds Fri, Nov 27
Buy 3 months, get 3 free
6 months of prescription MOTS-c for $597 ($99.50/mo), or $199 month to month. Prescribed by a U.S.-licensed provider, compounded by a licensed U.S. 503A pharmacy. No code needed, billed only if prescribed. Not FDA approved.
Frequently Asked Questions
How much is MOTS-c a month?
At Rx.com, $199 month to month, or $99.50 a month on the 6-month plan ($597 up front) during the Black Friday sale through November 27, 2026.
Will the price go up after Black Friday?
Prices after November 27 may change. The $597 six-month price is the Black Friday offer.
Why is research MOTS-c cheaper?
Research vials skip the provider, the prescription and the licensed pharmacy, and are labeled "not for human consumption." They are outside the FDA's 2026 compounding policy.
Does insurance cover MOTS-c?
Usually not. Compounded MOTS-c is not FDA approved, so plan to pay cash.
Do I need a prescription for MOTS-c?
For prescription MOTS-c from a 503A pharmacy, yes. A U.S.-licensed provider must review your intake and prescribe it.
Can I take MOTS-c if I have diabetes?
Talk to your provider first. MOTS-c has been studied for effects on blood sugar in mice, and it may not be right for people on diabetes medicine.
Is MOTS-c FDA approved?
No. MOTS-c is not FDA approved. A temporary 2026 FDA policy allows licensed 503A pharmacies to compound it for individual patients with a prescription.
Sources
- Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism, 2015. PubMed
- Reynolds JC, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications, 2021. PubMed
- U.S. Food and Drug Administration. Human drug compounding. fda.gov
- U.S. Food and Drug Administration and U.S. Department of Health and Human Services. Interim enforcement-discretion policy for compounding of certain peptides by 503A pharmacies and physicians (October 28, 2026). federalregister.gov
- U.S. Food and Drug Administration. BeSafeRx: Considering an online pharmacy? fda.gov
- U.S. Food and Drug Administration. MedWatch: The FDA Safety Information and Adverse Event Reporting Program. fda.gov
