Chlorzoxazone
Chlorzoxazone
What is Chlorzoxazone?
Chlorzoxazone (Lorzone, Parafon Forte DSC) is a prescription muscle relaxant used to relieve acute muscle spasms and musculoskeletal pain. It works by acting on the central nervous system to reduce muscle stiffness and discomfort and is typically used alongside rest, physical therapy, and other treatments.
Side Effects
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Drowsiness, dizziness, clumsiness
- Dark urine or pale stools, loss of appetite, nausea, vomiting, stomach pain, yellow eyes or skin
Warnings
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, or glaucoma.
- This medicine can cause drowsiness, dizziness, or blurred vision. Be careful when you drive a car or use machines.
- This medicine can cause your urine to turn orange or red. This is normal.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Prescription savings · · · ·
What is Chlorzoxazone ?
Chlorzoxazone (Lorzone, Parafon Forte DSC) is a prescription muscle relaxant used to relieve acute muscle spasms and musculoskeletal pain. It works by acting on the central nervous system to reduce muscle stiffness and discomfort and is typically used alongside rest, physical therapy, and other treatments.
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Drowsiness, dizziness, clumsiness
- Dark urine or pale stools, loss of appetite, nausea, vomiting, stomach pain, yellow eyes or skin
- Muscle weakness or slurred speech
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, or glaucoma.
- This medicine can cause drowsiness, dizziness, or blurred vision. Be careful when you drive a car or use machines.
- This medicine can cause your urine to turn orange or red. This is normal.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Chlorzoxazone Coupons & Prices
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Looking for a chlorzoxazone coupon? Chlorzoxazone is a low-cost generic muscle relaxant, but the cash price can vary widely from one pharmacy to the next, so comparing before you fill really pays off. Rx.com checks prices across more than 60,000 pharmacies so you can find a low price near you and use a free discount coupon at the counter. Enter your ZIP above to see today's price on chlorzoxazone in your area.
What is chlorzoxazone and how does it work?
Chlorzoxazone is a centrally-acting skeletal muscle relaxant. It is FDA-approved as an added treatment, alongside rest, physical therapy, and other measures, to relieve the discomfort of acute, painful musculoskeletal conditions such as muscle spasm, strains, and sprains. Doctors commonly prescribe it short-term for acute low back pain, neck pain, and muscle spasm.
Rather than acting directly on the muscle, chlorzoxazone works mainly at the spinal cord and lower brain areas, where it calms the multisynaptic reflex arcs that drive muscle spasm. It was sold under brand names such as Lorzone and Parafon Forte DSC; today it is available primarily as a generic, and it is not a controlled substance.
Chlorzoxazone cost and how to save without insurance
Chlorzoxazone is available as a generic, which usually keeps the price down. Even so, cash prices for the very same tablet can differ a lot depending on which pharmacy you use, so it is worth comparing rather than filling at the first counter. If you do not have insurance, or your plan does not cover it well, a free discount coupon can often beat the standard shelf price.
Rx.com compares chlorzoxazone prices across more than 60,000 pharmacies and shows you a free coupon you can present at pickup. Prices change often and are shown live on this page, so enter your ZIP above to see today's price near you. There is no manufacturer savings card for chlorzoxazone, but because it is an inexpensive generic, a discount coupon is typically the simplest way to lower the cash cost.
Chlorzoxazone vs. other muscle relaxants
Chlorzoxazone is one of several muscle relaxants used for short-term relief of acute muscle spasm and pain. Your provider chooses among them based on your symptoms, other medicines you take, and how each one tends to affect you. Common alternatives include:
Each of these is also available as a generic, and prices vary by pharmacy, so if your provider is open to more than one option it can be worth comparing coupon prices before you decide. This is general information, not medical advice; talk with your doctor or pharmacist about which muscle relaxant is right for you.
Safety information you should know
Serious, and rarely fatal, liver injury (hepatocellular toxicity) has been reported with chlorzoxazone. The reaction appears to be idiosyncratic and unpredictable, and the factors that raise a person's risk are not known. Stop the medicine and seek care right away if you notice early signs of liver trouble, such as fever, rash, loss of appetite, nausea, vomiting, unusual tiredness, pain in the upper-right belly, dark urine, or yellowing of the skin or eyes. Your provider may check liver enzymes (AST, ALT, alkaline phosphatase, bilirubin) during treatment.
Chlorzoxazone can cause drowsiness and dizziness, and this sedation is stronger when combined with alcohol or other medicines that slow the nervous system, so do not drive or operate machinery until you know how it affects you. It may upset your stomach and, rarely, cause GI bleeding, and it can harmlessly turn urine orange or purple-red. Use with caution if you have had an allergic reaction to it or prior drug-induced liver disease. It is meant for short-term use; the safety and benefit of long-term use are not established. This is not medical advice, always follow your prescriber's directions and ask your pharmacist if you have questions.
This Chlorzoxazone information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Chlorzoxazone on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.