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Glyxambi Tablet — prescription drug image

Glyxambi

Glyxambi 25-5MG

Prescriptions & Refills
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What is Glyxambi?

Glyxambi is a prescription medication used to improve blood sugar control in adults with type 2 diabetes. Combining two diabetes medicines, empagliflozin and linagliptin, Glyxambi helps lower glucose levels while offering potential savings through coupons and mail-order refills. Connect with a licensed provider on Rx.com to get started.

Prescription savings · · · ·

What is Glyxambi ?

Glyxambi is a prescription medication used to improve blood sugar control in adults with type 2 diabetes. Combining two diabetes medicines, empagliflozin and linagliptin, Glyxambi helps lower glucose levels while offering potential savings through coupons and mail-order refills. Connect with a licensed provider on Rx.com to get started.
  • Pain, tenderness, redness, or swelling of the area between the anus and genitals, fever, unusual tiredness or weakness
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Increased hunger, headache, confusion, shaking, trembling, sweating
  • Large, hard skin blisters
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Change in how much or how often you urinate, bloody urine, painful or difficult urination, lower back or side pain, chills
  • Severe joint pain
  • Fast or trouble breathing, cold sweat, bluish-colored skin
  • Lightheadedness, dizziness, fainting
  • Pain, tenderness, sores or ulcers, or infections on the leg or foot
  • Sudden or severe stomach pain, nausea, vomiting
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Tell your doctor if you are pregnant. Do not use this medicine during the second and third part of your pregnancy, unless your doctor tells you to.
  • Do not breastfeed during treatment with this medicine.
  • Tell your doctor if you have kidney disease, a history of pancreas problems, heart failure, urinary tract or genital yeast infections, leg problems (including amputation, blood vessel disease), or foot infection, sores, or ulcers. Tell your doctor if you drink alcohol, if you are on a low-salt diet, or if you are having surgery or other procedures that require fasting.
  • This medicine may cause the following problems:Pancreatitis (swelling of the pancreas)Heart failureLow blood pressureKetoacidosis (high ketones and acid in the blood), which can be life-threateningKidney problemsLow blood sugar, when used with other diabetes medicinesIncreased risk of genital yeast or urinary tract infectionsIncreased risk for leg, foot, or toe amputation (removal)Fournier's gangrene (skin or tissue damage of the area between the anus and genitals)Serious skin reactions
  • This medicine may cause some patients to become dehydrated. Drink plenty of water every day, during exercise, or in hot weather.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
What is Glyxambi used for?
Glyxambi is used along with diet and exercise to improve blood sugar control in adults with type 2 diabetes. It combines empagliflozin (an SGLT2 inhibitor) and linagliptin (a DPP-4 inhibitor) in one tablet. The empagliflozin ingredient is also approved to lower the risk of death from heart disease in adults who have type 2 diabetes and established cardiovascular disease. It is not used for type 1 diabetes or to treat diabetic ketoacidosis.
Is there a generic version of Glyxambi?
No. As of 2026 there is no FDA-approved generic for the empagliflozin/linagliptin combination sold as Glyxambi, so only the brand is available. Because there is no generic, a cash coupon or the manufacturer's savings program can help lower your out-of-pocket cost. Your provider may also discuss related medicines, some of whose individual ingredients are still brand-only as well.
What are the most common side effects of Glyxambi?
The most commonly reported side effects are urinary tract infections and upper respiratory (nose and throat) infections. Other possible effects include genital yeast infections, increased urination, and dehydration. Less common but serious risks include diabetic ketoacidosis, kidney problems, and low blood sugar when taken with insulin or a sulfonylurea. Contact your provider about any side effect that worries you, and seek care right away for severe symptoms.
How much does Glyxambi cost with a savings card?
The price depends on your pharmacy, location, and which discount you use. Boehringer Ingelheim offers an official manufacturer savings program for eligible patients, but manufacturer copay cards are generally limited to people with commercial insurance and the terms vary. If you are uninsured, on Medicare, or the card is declined, the Rx.com cash coupon may help instead. Enter your ZIP above to see today's Glyxambi price near you.
Can Glyxambi cause weight loss?
Some people taking Glyxambi may notice modest weight loss, partly because the empagliflozin component causes the body to pass extra sugar in the urine. However, Glyxambi is a diabetes medicine and is not approved or intended as a weight-loss drug, and it should never be used for that purpose. If weight is a concern, talk with your provider about a safe, appropriate plan.
How much does Glyxambi cost without insurance?
The price of Glyxambi without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 42% off retail prices with a free Rx.com coupon.
What are the common side effects of Glyxambi?
Common side effects of Glyxambi may include: Pain, tenderness, redness, or swelling of the area between the anus and genitals, fever, unusual tiredness or weakness, Rapid weight gain, swelling in your hands, ankles, or feet, Increased hunger, headache, confusion, shaking, trembling, sweating, Large, hard skin blisters, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Glyxambi?
Generic versions may be available for Glyxambi. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Glyxambi on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Glyxambi?
The cheapest pharmacy for Glyxambi depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Glyxambi near you.

Glyxambi Coupons & Prices

Glyxambi 25-5MG

Prescriptions & Refills
Licensed US providers · Online visit in minutes
Glyxambi Tablet — prescription drug image
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Glyxambi prices by dosage

Lowest cash price with a free Rx.com coupon vs. the average retail price.

Dosage Quantity Retail price Rx.com price
10-5mg · Tablet 30 $447.95 $242.95
25-5mg · Tablet 30 $415.99 $242.95

Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.

If you have been prescribed Glyxambi and are looking for a coupon, Rx.com offers a free cash discount that you can use at the pharmacy counter. Glyxambi is a brand-name combination tablet (empagliflozin plus linagliptin) for type 2 diabetes, and because there is no generic version yet, the retail price can be high. Our coupon is not insurance; it is a cash price you can compare against your plan. Enter your ZIP above to see today's Glyxambi price at pharmacies near you.

What is Glyxambi and how does it work?

Glyxambi is a fixed-dose combination tablet that pairs two diabetes medicines in one pill: empagliflozin, an SGLT2 inhibitor, and linagliptin, a DPP-4 inhibitor. It is FDA-approved as an add-on to diet and exercise to improve blood sugar control in adults with type 2 diabetes. The two ingredients work in different ways, which is why they are combined.

The empagliflozin part helps your kidneys remove extra sugar from the body through the urine. The linagliptin part helps your body release more of its own insulin after meals and lower the amount of sugar the liver makes. Empagliflozin is also separately approved to lower the risk of death from heart disease in adults who have type 2 diabetes along with established cardiovascular disease. Glyxambi is not for type 1 diabetes and is not used to treat diabetic ketoacidosis. Always take it exactly as your provider directs.

Glyxambi cost: manufacturer savings card vs. Rx.com cash coupon

There is no generic for Glyxambi, so cash prices reflect the brand cost. Boehringer Ingelheim, the maker, offers an official manufacturer savings program on its website for eligible patients. Manufacturer copay cards like this are generally limited to people with commercial (private) insurance, and the terms, eligibility, and any expiration vary, so read the program details carefully. People with Medicare, Medicaid, or other government coverage usually cannot use a manufacturer copay card.

The Rx.com cash coupon works differently. It is a discount you can use whether or not you have insurance, including if you are uninsured, on Medicare, or if the manufacturer card is declined at the counter. You cannot combine a cash coupon with your insurance on the same purchase, but it is worth comparing both to see which is lower. Boehringer Ingelheim also runs a patient assistance program for qualifying patients who cannot afford their medication; you can ask your provider or the manufacturer about eligibility. Enter your ZIP above to see today's Glyxambi cash price near you.

Glyxambi alternatives and related diabetes medicines

Glyxambi combines two ingredients that are also sold on their own and in other combinations. If cost is a concern, ask your provider whether one of these related options fits your treatment plan:

  • Jardiance contains empagliflozin alone (the SGLT2 inhibitor in Glyxambi).
  • Tradjenta contains linagliptin alone (the DPP-4 inhibitor in Glyxambi).
  • Synjardy combines empagliflozin with metformin.
  • Jentadueto combines linagliptin with metformin.
  • Trijardy XR combines empagliflozin, linagliptin, and metformin in one tablet.

These are all brand-name products, so a cash coupon can help with each. Only your provider can decide which combination and dose is right for you; do not switch medicines on your own.

Glyxambi safety and side effects

Glyxambi does not carry an FDA boxed warning, but it has important risks to know. The most commonly reported side effects include urinary tract infections and upper respiratory infections. More serious risks include diabetic ketoacidosis (a dangerous buildup of acid in the blood that can happen even when blood sugar is near normal), dehydration and low blood pressure, acute kidney injury, serious urinary tract infections such as kidney infection and urosepsis, genital yeast infections, and a rare but serious infection of the tissue around the genitals and rectum (Fournier's gangrene). Low blood sugar is more likely if Glyxambi is combined with insulin or a sulfonylurea.

The linagliptin component can rarely cause inflammation of the pancreas (pancreatitis), serious allergic reactions, severe joint pain, and a blistering skin condition called bullous pemphigoid. Glyxambi should not be used if your kidney function is low (an eGFR below 30) or if you are allergic to either ingredient. This is not a complete list and not medical advice. Talk with your doctor or pharmacist about your full history and any warning signs before and while taking Glyxambi.

Sources & accuracy

This Glyxambi information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Glyxambi on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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