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Griseofulvin Microsize Tablet — prescription drug image

Griseofulvin Microsize

Griseofulvin Microsize 500MG

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What is Griseofulvin Microsize?

Griseofulvin Microsize is used to treat certain fungal infections Griseofulvin Microsize is a generic drug. On average Griseofulvin Microsize is priced at about $232 for 30, 500 mg tablets. Luckily, you can use our Rx.com savings offer to receive a Griseofulvin Microsize discount of up to 80% off the retail price at participating pharmacies near you.

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What is Griseofulvin Microsize ?

Griseofulvin Microsize is used to treat certain fungal infections Griseofulvin Microsize is a generic drug. On average Griseofulvin Microsize is priced at about $232 for 30, 500 mg tablets. Luckily, you can use our Rx.com savings offer to receive a Griseofulvin Microsize discount of up to 80% off the retail price at participating pharmacies near you.
  • Headache
  • Nausea
  • Vomiting
  • Diarrhea
  • Fatigue
  • Dizziness
  • Insomnia
  • Urticaria (hives)
  • Avoid exposure to sunlight or tanning beds as griseofulvin can make you sunburn more easily.
  • Griseofulvin may interact with other medications such as warfarin and may increase the risk of bleeding.
  • Griseofulvin can increase liver enzymes and should be used cautiously in individuals with liver disease.
  • Use effective birth control to prevent pregnancy while you are using this medicine, as griseofulvin can harm an unborn baby.
  • Do not drink alcohol while taking griseofulmore, as it can enhance side effects such as dizziness or upset stomach.
  • May cause an increase in certain types of white blood cells.
  • May cause severe skin reactions and other allergies, especially in patients with a history of penicillin allergy.
What is griseofulvin microsize used for?
Griseofulvin microsize is an oral antifungal approved to treat ringworm (dermatophyte) infections of the skin, hair, and nails that topical antifungals have not cleared. That includes tinea corporis (body ringworm), tinea pedis (athlete's foot), tinea cruris (jock itch), tinea barbae (barber's itch), tinea capitis (scalp ringworm), and tinea unguium (fungal nail infection) caused by susceptible Trichophyton, Microsporum, and Epidermophyton species. It is still a first-line option for scalp ringworm in children. It does not treat bacteria, Candida or other yeasts, tinea versicolor, or nondermatophyte molds.
How long does it take for griseofulvin to work for ringworm or nail fungus?
Longer than most people expect, because the drug works by letting healthy, uninfected keratin grow in. The FDA labeling gives these representative treatment periods: tinea corporis (body ringworm), 2 to 4 weeks; tinea capitis (scalp ringworm), 4 to 6 weeks; tinea pedis (athlete's foot), 4 to 8 weeks; and tinea unguium (nail infection), depending on how fast the nail grows, at least 4 months for fingernails and at least 6 months for toenails. Athlete's foot in particular usually needs a longer course than body ringworm, so do not stop at the 2-to-4-week mark. Finish the full course your prescriber ordered even if the area starts looking better, and follow up if it is not improving.
Should griseofulvin be taken with food?
Yes. Griseofulvin is absorbed better when it is taken with a fatty meal, so taking each dose with food that contains some fat helps the medicine reach the level it needs to work. Follow the directions on your prescription label and ask your pharmacist if you are unsure.
What is the difference between griseofulvin microsize and ultramicrosize (Gris-PEG)?
They are two different formulations of the same drug with different particle sizes, and they are absorbed differently. Because of that, they are not interchangeable milligram for milligram, and the dose written for one form is not the dose for the other. Both forms are available as generics: microsize griseofulvin is generic-only, and ultramicrosize griseofulvin is sold under the brand Gris-PEG and also as a generic ultramicrosize tablet. Take whichever form your prescriber wrote for, do not switch on your own, and make sure the coupon you pull up matches the form on your prescription.
Can you drink alcohol or take birth control pills while on griseofulvin?
Alcohol can cause a disulfiram-like reaction with griseofulvin, including flushing, a fast heartbeat, nausea, and vomiting, so it is best avoided during treatment. Griseofulvin also reduces the effectiveness of estrogen-containing oral contraceptives and can cause breakthrough bleeding, so use a backup method of birth control. This matters a great deal here, because griseofulvin is contraindicated in pregnancy: effective contraception should continue during treatment and for one month after the last dose. Talk with your prescriber about the right plan for you.
How much does Griseofulvin Microsize cost without insurance?
The price of Griseofulvin Microsize without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Griseofulvin Microsize?
Common side effects of Griseofulvin Microsize may include: Headache, Nausea, Vomiting, Diarrhea, Fatigue. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Griseofulvin Microsize?
Generic versions may be available for Griseofulvin Microsize. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Griseofulvin Microsize on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Griseofulvin Microsize?
The cheapest pharmacy for Griseofulvin Microsize depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Griseofulvin Microsize near you.

Griseofulvin Microsize Coupons & Prices

Griseofulvin Microsize 500MG

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Griseofulvin Microsize Tablet — prescription drug image
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Use a free Rx.com griseofulvin (microsize) coupon to compare cash prices at more than 60,000 pharmacies before you fill your prescription. Griseofulvin microsize is an oral antifungal used for ringworm infections of the skin, hair, and nails, and it is now sold in the United States as a generic only, so there is no brand product and no manufacturer savings card to apply. Cash prices for the same tablets or oral suspension can differ a lot from one pharmacy to the next, and courses often run for weeks or months, so it pays to compare before every fill. Enter your ZIP code above to see today's price near you and print, text, or show the coupon at the counter.

What is griseofulvin (microsize) and how does it work?

Griseofulvin is a systemic (oral) antifungal antibiotic originally derived from Penicillium species. It is fungistatic: it collects in the keratin-forming cells of your skin, hair, and nails and disrupts the fungus's mitotic spindle and microtubule function, so the fungus cannot multiply while healthy, uninfected keratin grows in to replace the infected tissue. That is why treatment takes time rather than working overnight.

It is FDA-approved for dermatophyte (ringworm) infections that topical antifungals have not cleared, including tinea corporis (body ringworm), tinea pedis (athlete's foot), tinea cruris (jock itch), tinea barbae (barber's itch), tinea capitis (scalp ringworm), and tinea unguium (fungal nail infection), caused by susceptible Trichophyton, Microsporum, and Epidermophyton species. It remains a first-line choice for scalp ringworm in children, especially Microsporum infections. Griseofulvin does not work against bacteria, Candida or other yeasts, tinea versicolor, or nondermatophyte molds, so the diagnosis matters.

Griseofulvin microsize cost and coupon savings without insurance

Microsize griseofulvin is marketed generically. The older brands (Grifulvin V, Fulvicin-U/F, and Grisactin) have all been discontinued, so there is no brand-name version to buy and no manufacturer copay or savings card for this product. What you pay is a cash price set pharmacy by pharmacy, and the spread between a big chain, a grocery pharmacy, and an independent down the street can be surprisingly wide for the exact same prescription.

That is what a discount coupon is for. Rx.com compares cash prices across more than 60,000 pharmacies, and our coupon is free to use whether or not you have insurance. It is worth checking even if you are insured, because a cash price with a coupon can sometimes land below a plan copay, and courses of griseofulvin are long: a nail infection may need several months of refills, so a per-fill difference repeats every month. Enter your ZIP above to see today's price for your strength and quantity, then bring the coupon to the pharmacy counter. Prices change, so it is worth re-checking each refill.

Griseofulvin microsize vs. ultramicrosize and other antifungals

The most important comparison is with the other griseofulvin form. Griseofulvin ultramicrosize (brand Gris-PEG, also available generically) is absorbed differently from microsize griseofulvin. The two are not interchangeable milligram for milligram, and a lower ultramicrosize dose can deliver a comparable amount of drug. Never swap one for the other on your own or assume the pharmacy can substitute them; ask your prescriber, and check that the coupon you pull up matches the form on your prescription.

Other oral antifungals are used for many of the same infections, and your prescriber chooses based on the fungus, the site, your age, your other medicines, and your liver health:

  • Terbinafine is commonly used for fungal nail infections and some skin infections.
  • Itraconazole is an azole antifungal used for several dermatophyte and other fungal infections.
  • Fluconazole is another azole, best known for yeast infections, and is sometimes used for certain skin fungal infections.

Griseofulvin's long track record in children with scalp ringworm is a reason it is still prescribed. Each of these alternatives has its own monitoring and drug-interaction profile, so this is a conversation for your prescriber rather than a swap you make at the pharmacy.

Safety, side effects, and interactions to know

This is a summary, not medical advice; read the label your pharmacy gives you and talk with your prescriber. Griseofulvin is contraindicated in pregnancy. It can cause fetal harm, and cases of conjoined twins have been reported. Women who can become pregnant should use effective contraception during treatment and for one month after finishing, and men should wait at least six months after therapy before fathering a child. It is also contraindicated in porphyria, in hepatocellular failure, and in anyone with a prior allergic reaction to griseofulvin. Cross-sensitivity with penicillin is possible but rare.

Other important cautions:

  • Liver: elevated AST, ALT, and bilirubin, and jaundice, have been reported. Long courses warrant periodic checks of liver, kidney, and blood counts (CBC).
  • Serious skin reactions: Stevens-Johnson syndrome, toxic epidermal necrolysis, and erythema multiforme have been reported. Stop the drug and contact your provider right away for a severe rash, blistering, or peeling.
  • Sun: griseofulvin causes photosensitivity. Avoid intense or prolonged sun exposure. It may also bring on or worsen lupus-like reactions.
  • Alcohol: drinking can cause a disulfiram-like reaction with flushing, fast heartbeat, nausea, and vomiting.
  • Interactions: griseofulvin reduces the activity of warfarin-type anticoagulants (your INR should be monitored and the dose may need adjusting) and reduces the effectiveness of estrogen-containing birth control pills, which can cause breakthrough bleeding, so use a backup method. Barbiturates reduce griseofulvin's absorption and activity and may require a dosage change. Some griseofulvin labeling and drug references also report reduced cyclosporine levels and effect; if you take cyclosporine, have your prescriber check.

Tell your pharmacist and prescriber about every medicine and supplement you take before you start.

Sources & accuracy

This Griseofulvin Microsize information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Griseofulvin Microsize on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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