Leflunomide
Leflunomide 20MG
What is Leflunomide?
Leflunomide is a disease-modifying antirheumatic drug (DMARD) primarily used to manage the symptoms of rheumatoid arthritis and psoriatic arthritis. It works by inhibiting the enzyme dihydroorotate dehydrogenase, which is crucial in the synthesis of pyrimidine nucleotides and thus reduces inflammation and slows the progression of the disease. Leflunomide also has immunomodulatory properties that help in reducing joint damage and improving physical function.Side Effects
- Chest pain or discomfort, trouble breathing
- Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow eyes or skin
- Unusual bleeding, bruising, or weakness
Warnings
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Tell your doctor if you have kidney disease, liver disease, diabetes, any infection, lung disease, or a history of tuberculosis or blood or bone marrow problems.
- This medicine may cause the following problems:Liver problemsSerious skin reactions, including drug reaction with eosinophilia and systemic reaction which can cause organ damagePossible increased risk of cancerNerve problemsLung problems
- This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
- Unusual bleeding, bruising, or weakness
Prescription savings · · · ·
What is Leflunomide ?
Leflunomide is a disease-modifying antirheumatic drug (DMARD) primarily used to manage the symptoms of rheumatoid arthritis and psoriatic arthritis. It works by inhibiting the enzyme dihydroorotate dehydrogenase, which is crucial in the synthesis of pyrimidine nucleotides and thus reduces inflammation and slows the progression of the disease. Leflunomide also has immunomodulatory properties that help in reducing joint damage and improving physical function.- Chest pain or discomfort, trouble breathing
- Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow eyes or skin
- Unusual bleeding, bruising, or weakness
- Fever, chills, cough, sore throat, body aches
- Blistering, peeling, or red skin rash
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Numbness, tingling, or burning pain in your hands, arms, legs, or feet
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Tell your doctor if you have kidney disease, liver disease, diabetes, any infection, lung disease, or a history of tuberculosis or blood or bone marrow problems.
- This medicine may cause the following problems:Liver problemsSerious skin reactions, including drug reaction with eosinophilia and systemic reaction which can cause organ damagePossible increased risk of cancerNerve problemsLung problems
- This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
- Unusual bleeding, bruising, or weakness
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. Your doctor will also check your blood pressure.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Leflunomide Coupons & Prices
Leflunomide 20MG
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Licensed U.S. providers · No insurance needed · Shipped to your door
Leflunomide is a prescription disease-modifying antirheumatic drug (DMARD) used for active rheumatoid arthritis. If your pharmacy quoted a high price, a leflunomide coupon can help, since cash prices for this generic tablet vary a lot from one pharmacy to the next. Enter your ZIP above to see today's price near you.
What Is Leflunomide and How Does It Work?
Leflunomide is a DMARD tablet FDA-approved to treat active rheumatoid arthritis in adults, either alone or together with other medications. It works by slowing the immune system activity that drives joint inflammation, pain, and swelling. Leflunomide was first approved in the U.S. under the brand name Arava, and today it is dispensed almost exclusively as the generic tablet.
Comparing Leflunomide Prices
Because leflunomide is a widely available generic, cash prices can differ significantly between pharmacies in the same city. Rx.com compares prices at more than 60,000 U.S. pharmacies so you can find a lower cash price or use a free coupon at checkout, whether or not you have insurance.
- Prices vary by pharmacy, dose, and quantity dispensed
- A coupon can help if your insurance copay is high or you don't have drug coverage
- Always compare before you fill, even at the same pharmacy chain
Leflunomide vs. Other RA Treatments
Leflunomide is one of several conventional DMARDs used for rheumatoid arthritis, alongside options like methotrexate and hydroxychloroquine. Your rheumatologist chooses among these based on your health history, other medications, and how you respond to treatment. It's sometimes combined with methotrexate for people who need additional disease control.
Safety Information
Leflunomide carries boxed warnings for serious liver injury, including rare cases of fatal liver failure, and for harm to a developing fetus if taken during pregnancy. Your provider will check liver function tests before and during treatment and will discuss effective contraception if you can become pregnant. This is general information, not medical advice — talk to your prescriber or pharmacist about your specific situation before starting or stopping leflunomide.
This Leflunomide information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Leflunomide on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.
