Mefenamic Acid
Mefenamic Acid 250MG
What is Mefenamic Acid?
Mefenamic Acid is a nonsteroidal anti-inflammatory drug used to treat patients with mild to moderate pain. Mefenamic Acid is a generic drug. Mefenamic Acid costs around $105 for a supply of 30, 250 mg capsules, but there are ways to save money. You can use our Rx.com Mefenamic Acid savings card to save significantly on the retail price at participating pharmacies near you.Side Effects
- Sudden and severe stomach pain, nausea, vomiting, fever, and lightheadedness.
- Unusual bleeding, bruising, or weakness.
- Problems with vision, speech, or walking.
Warnings
- Tell your doctor if you are pregnant. Do not use this medicine during the later part of a pregnancy, unless your doctor tells you to.
- Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, asthma, high blood pressure, heart or blood vessel problems, heart failure, a recent heart attack, or a history of stomach ulcers or bleeding problems. Tell your doctor if you smoke or drink alcohol.
- This medicine may cause the following problems:Increased risk of blood clots, heart attack, stroke, or heart failureStomach or bowel problems (including bleeding, ulcers, or perforation)Liver problemsHigh blood pressureKidney problemsSerious skin reactions, including exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms (DRESS)
- This medicine may cause a delay in ovulation for women and may affect their ability to have children. If you plan to have children, talk with your doctor before using this medicine.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
Prescription savings · · · ·
What is Mefenamic Acid ?
Mefenamic Acid is a nonsteroidal anti-inflammatory drug used to treat patients with mild to moderate pain. Mefenamic Acid is a generic drug. Mefenamic Acid costs around $105 for a supply of 30, 250 mg capsules, but there are ways to save money. You can use our Rx.com Mefenamic Acid savings card to save significantly on the retail price at participating pharmacies near you.- Sudden and severe stomach pain, nausea, vomiting, fever, and lightheadedness.
- Unusual bleeding, bruising, or weakness.
- Problems with vision, speech, or walking.
- Shortness of breath, cold sweat, and bluish-colored skin.
- Sudden or severe headache.
- Vomiting blood or something that looks like coffee grounds.
- Swelling in your hands, ankles, or feet.
- Yellowing of your skin or the whites of your eyes.
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, red skin rash
- Bloody or black, tarry stools, severe stomach pain, vomiting blood or material that looks like coffee grounds
- Change in how much or how often you urinate
- Chest pain that may spread, trouble breathing, coughing up blood, unusual sweating, fainting
- Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
- Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking
- Rapid weight gain, swelling in your hands, ankles, or feet
- Skin rash or blisters with fever.
- Unusual bleeding, bruising, or weakness
- Tell your doctor if you are pregnant. Do not use this medicine during the later part of a pregnancy, unless your doctor tells you to.
- Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, asthma, high blood pressure, heart or blood vessel problems, heart failure, a recent heart attack, or a history of stomach ulcers or bleeding problems. Tell your doctor if you smoke or drink alcohol.
- This medicine may cause the following problems:Increased risk of blood clots, heart attack, stroke, or heart failureStomach or bowel problems (including bleeding, ulcers, or perforation)Liver problemsHigh blood pressureKidney problemsSerious skin reactions, including exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms (DRESS)
- This medicine may cause a delay in ovulation for women and may affect their ability to have children. If you plan to have children, talk with your doctor before using this medicine.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Liver problems may occur while you are using this medicine. Stop using this medicine and check with your doctor right away if you are having more than one of these symptoms: abdominal pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; itching; loss of appetite; nausea and vomiting; skin rash; swelling of the feet or lower legs; unusual tiredness or weakness; or yellow eyes or skin.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Skin rash or blisters with fever.
- Sudden and severe stomach pain, nausea, vomiting, fever, and lightheadedness.
- Sudden or severe headache.
- Swelling in your hands, ankles, or feet.
- Unusual bleeding, bruising, or weakness.
- Vomiting blood or something that looks like coffee grounds.
- Yellowing of your skin or the whites of your eyes.
Mefenamic Acid Coupons & Prices
Mefenamic Acid 250MG
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Mefenamic acid is a prescription NSAID (nonsteroidal anti-inflammatory drug) capsule used short-term for mild-to-moderate pain and menstrual cramps. It's sold only as a generic in the US today, and cash prices for the same 250 mg capsule can vary a lot from one pharmacy to the next. If you're filling a mefenamic acid prescription, a mefenamic acid coupon from Rx.com lets you compare pharmacy prices in your area and enter your ZIP above to see today's price before you check out.
What is mefenamic acid and how does it work?
Mefenamic acid belongs to the fenamate class of NSAIDs. Like other NSAIDs, it works by blocking cyclooxygenase (COX) enzymes, which reduces the body's production of prostaglandins - the chemicals that drive pain, inflammation, and the uterine cramping of menstruation. It's taken by mouth as a capsule.
The FDA label limits mefenamic acid to short courses: relief of mild-to-moderate pain when treatment won't exceed one week, and treatment of primary dysmenorrhea (menstrual pain). It is not intended for long-term daily use.
Comparing pharmacy prices for mefenamic acid
Because mefenamic acid is generic-only, the brand it was originally sold under, Ponstel, is no longer marketed in the US, and price differences between pharmacies come down to each pharmacy's own markup and dispensing fee rather than brand-vs-generic pricing. Cash prices can swing widely for the exact same 250 mg capsule depending on where you fill it. Rx.com compares pricing across 60,000+ US pharmacies so you can see which one is offering the lowest price near you before you fill.
- Prices vary by pharmacy, not just by insurance status
- A cash coupon can sometimes beat your insurance copay - it's worth comparing both
Alternatives to mefenamic acid
For general mild-to-moderate pain, other over-the-counter and prescription NSAIDs such as ibuprofen and naproxen work through the same mechanism and are commonly used instead. For menstrual pain specifically, ibuprofen and naproxen are also frequently used first-line options; your provider can help decide which NSAID fits your situation, since response and tolerability can differ person to person.
Safety information
Like all NSAIDs, mefenamic acid carries a boxed warning for an increased risk of serious cardiovascular events, including heart attack and stroke, which can occur even without warning signs and can be fatal; this risk may rise with longer use. NSAIDs also carry a boxed warning for serious gastrointestinal risks, including bleeding, ulceration, and perforation of the stomach or intestines, which can happen at any time and without warning symptoms - older adults and people with a prior history of ulcers or GI bleeding are at higher risk.
Mefenamic acid should not be used by anyone with an allergy to aspirin or other NSAIDs, or in the setting of coronary artery bypass graft (CABG) surgery. This is general information, not medical advice - talk with your doctor or pharmacist about whether mefenamic acid is right for you, especially if you have heart, kidney, or GI conditions.
This Mefenamic Acid information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Mefenamic Acid on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.
