Nitrofurantoin Macrocrystal
Nitrofurantoin Macrocrystal 100MG
What is Nitrofurantoin Macrocrystal?
Macrodantin is an antibiotic used to treat urinary tract infections. Nitrofurantoin is the generic version. On average Macrodantin is priced at about $176 for a supply of 14, 100 mg macrocrystals capsules. Luckily, you can use our Rx.com savings offer to receive a Macrodantin discount of up to 80% off the retail price at participating pharmacies near you.Side Effects
- Cough, fever, chills, weakness, shortness of breath, or chest pain.
- Dark-colored urine or pale stools.
- Blisters, peeling, or red skin rash.
Warnings
- Yellowing of your skin or the whites of your eyes.
- Nausea, vomiting, loss of appetite, or pain in your upper stomach.
- Numbness, tingling, or burning pain in your hands, arms, legs, or feet.
- Make sure your doctor knows if you are pregnant or breastfeeding, or if you have liver disease, heart disease, lung disease, anemia, diabetes, a mineral imbalance in the blood, or vitamin B deficiency. Make sure your doctor knows if you have a condition called G6PD-deficiency.
- This medicine may cause your urine to be a brown color. This is normal and will not affect how the medicine works.
Prescription savings · · · ·
What is Nitrofurantoin Macrocrystal ?
Macrodantin is an antibiotic used to treat urinary tract infections. Nitrofurantoin is the generic version. On average Macrodantin is priced at about $176 for a supply of 14, 100 mg macrocrystals capsules. Luckily, you can use our Rx.com savings offer to receive a Macrodantin discount of up to 80% off the retail price at participating pharmacies near you.- Cough, fever, chills, weakness, shortness of breath, or chest pain.
- Dark-colored urine or pale stools.
- Blisters, peeling, or red skin rash.
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Diarrhea or loose, watery stools that may contain blood.
- Yellowing of your skin or the whites of your eyes.
- Nausea, vomiting, loss of appetite, or pain in your upper stomach.
- Numbness, tingling, or burning pain in your hands, arms, legs, or feet.
- Yellowing of your skin or the whites of your eyes.
- Nausea, vomiting, loss of appetite, or pain in your upper stomach.
- Numbness, tingling, or burning pain in your hands, arms, legs, or feet.
- Make sure your doctor knows if you are pregnant or breastfeeding, or if you have liver disease, heart disease, lung disease, anemia, diabetes, a mineral imbalance in the blood, or vitamin B deficiency. Make sure your doctor knows if you have a condition called G6PD-deficiency.
- This medicine may cause your urine to be a brown color. This is normal and will not affect how the medicine works.
- This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
- Use this medicine only to treat the infection you now have. This medicine will not work for colds, flu, or other virus infections.
- If you take this medicine to prevent a urine infection, you may take it for a long time. Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Nitrofurantoin Macrocrystal Coupons & Prices
Nitrofurantoin Macrocrystal 100MG
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Nitrofurantoin Macrocrystal prices by dosage
Lowest cash price with a free Rx.com coupon vs. the average retail price.
| Dosage | Quantity | Retail price | Rx.com price |
|---|---|---|---|
| 25mg · Capsule | 30 | $332.99 | $52.88 |
| 50mg · Capsule | 14 | $25.59 | $11.20 |
| 100mg · Capsule | 14 | $38.19 | $13.70 |
Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.
Looking for a nitrofurantoin macrocrystal coupon? Nitrofurantoin (macrocrystals) is a widely used generic antibiotic for uncomplicated urinary tract infections, and because it is available as a generic it is already one of the lower-cost UTI treatments. Even so, the cash price can vary a lot from one pharmacy to the next, so comparing before you fill matters. Rx.com compares prices across more than 60,000 pharmacies so you can find the best price near you. Enter your ZIP above to see today's price on nitrofurantoin macrocrystal at pharmacies close to you.
What is nitrofurantoin macrocrystal and how does it work?
Nitrofurantoin (macrocrystals) is a nitrofuran antibiotic, also called a urinary anti-infective. It is FDA-approved to treat acute uncomplicated urinary tract infections, such as bladder infections (cystitis), caused by susceptible bacteria including certain strains of E. coli, Enterococcus, Staphylococcus aureus, and some Klebsiella and Enterobacter species. It works by concentrating in the urine and damaging the bacteria that cause the infection.
The "macrocrystal" form uses larger crystals that are absorbed more slowly, which can help reduce stomach upset. It is sold under brand names such as Macrodantin, and the closely related Macrobid is a nitrofurantoin monohydrate/macrocrystals product. Doctors sometimes also prescribe low-dose nitrofurantoin over a longer period to help prevent repeated UTIs. Important: nitrofurantoin is not effective for kidney infections (pyelonephritis), prostate infections, or infections that have spread through the body. This information is educational and is not a substitute for your provider's advice.
Nitrofurantoin macrocrystal cost and coupons without insurance
Because nitrofurantoin macrocrystal is available as a generic, it is generally an affordable UTI antibiotic even if you are paying cash without insurance. The catch is that the price you actually pay can differ widely between pharmacies for the very same prescription, so it pays to compare instead of filling at the first pharmacy you see.
Rx.com shows live cash prices and free coupons across more than 60,000 U.S. pharmacies. Prices change often and depend on your location, the quantity, and the strength your provider prescribes, so we do not list a fixed dollar amount here. Enter your ZIP above to see today's price on nitrofurantoin macrocrystal near you, then bring the coupon to the pharmacy counter. You do not need insurance to use it.
Alternatives and related UTI antibiotics
Nitrofurantoin macrocrystal is one of several first-line options for uncomplicated UTIs. If it is not right for you, or if your infection is caused by bacteria it does not cover, your provider may consider another antibiotic. Related and alternative options include:
- Macrobid and Macrodantin — brand-name forms of nitrofurantoin
- Nitrofurantoin — the general generic listing
- Trimethoprim-sulfamethoxazole (Bactrim) — a common UTI antibiotic combination
- Ciprofloxacin — a fluoroquinolone antibiotic
- Cephalexin — a cephalosporin antibiotic
Which antibiotic is best depends on the bacteria involved, your kidney function, allergies, and other health factors. Only your provider can choose the right one for you. You can compare cash prices on any of these on Rx.com by entering your ZIP.
Safety and important warnings
Nitrofurantoin is effective, but it does carry some important risks to be aware of. Take it with food to help absorption and reduce stomach upset. Talk to your provider about any of the following, and seek care if serious symptoms appear:
- Lung problems: acute, subacute, or chronic pulmonary reactions (including pulmonary fibrosis), more likely with long-term use — report a persistent cough or shortness of breath.
- Liver problems: rare but potentially serious hepatotoxicity (hepatitis, cholestatic jaundice).
- Nerve problems: peripheral neuropathy (numbness or tingling in the fingers and toes) that can become severe; risk is higher with kidney impairment, anemia, diabetes, electrolyte imbalance, or vitamin B deficiency.
- Hemolytic anemia in people with G6PD deficiency, and possible C. difficile-associated diarrhea.
Nitrofurantoin should not be used if you have significant kidney impairment (creatinine clearance under 60 mL/min or clinically significant elevated serum creatinine), during pregnancy at term (38 to 42 weeks), during labor and delivery, or in babies under 1 month old, because of the risk of hemolytic anemia. This is not a complete list of warnings and is not medical advice — review your full history and any other medicines with your doctor or pharmacist.
This Nitrofurantoin Macrocrystal information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Nitrofurantoin Macrocrystal on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.