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Phenobarbital Tablet — prescription drug image

Phenobarbital

PHENobarbital 16.2MG

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What is Phenobarbital?

Phenobarbital is a prescription medication primarily used to control seizures and manage anxiety. By slowing down brain activity, it helps prevent seizures and promote calmness. Users can find information on cost, savings cards, and mail-order options on Rx.com, where they can also connect with licensed providers for prescriptions online.

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What is Phenobarbital ?

Phenobarbital is a prescription medication primarily used to control seizures and manage anxiety. By slowing down brain activity, it helps prevent seizures and promote calmness. Users can find information on cost, savings cards, and mail-order options on Rx.com, where they can also connect with licensed providers for prescriptions online.
  • Hives or severe skin rash
  • Swelling of eyelids or face
  • Severe drowsiness, confusion, or slurred speech
  • Shortness of breath or trouble breathing
  • Uncontrollable eye movements
  • Hallucinations
  • Yellowing of eyes or skin
  • Check with your doctor before taking if you are pregnant, breastfeeding, or are planning to become pregnant, or if you have any type of lung disease, asthma, or liver disease.
  • If you are using this medicine regularly, do not stop taking it suddenly without first asking your doctor. You may need to take less and less before stopping completely.
  • You should not use more of this medicine or take it for longer periods than your doctor has ordered. Phenobarbital can be habit-forming.
  • This medicine can make you drowsy. Be careful when driving or operating machinery.
  • Uncontrollable eye movements
  • Yellowing of eyes or skin
  • Hallucinations
Is phenobarbital a controlled substance?
Yes. Phenobarbital is classified as a Schedule IV (C-IV) controlled substance in the United States, reflecting its potential for dependence and misuse.
What is phenobarbital used for?
Phenobarbital is FDA-approved as an anticonvulsant to help control generalized tonic-clonic (grand mal) and partial seizures, and for emergency control of certain acute convulsive episodes such as status epilepticus, or seizures related to eclampsia, meningitis, tetanus, or toxic reactions to strychnine or local anesthetics. It's also approved as a sedative for daytime sedation and pre-anesthetic sedation. It is also used off-label for conditions such as neonatal seizures and alcohol or benzodiazepine withdrawal management.
Can you stop taking phenobarbital suddenly?
No. Phenobarbital should never be stopped abruptly. Because the body can become physically dependent on it, sudden discontinuation can cause a serious, potentially life-threatening withdrawal, including seizures. Any dose changes or stopping the medication should be done gradually and only under a doctor's supervision.
What are the side effects of phenobarbital?
Phenobarbital carries several serious risks: combining it with opioids or other central nervous system depressants can cause profound sedation, dangerously slowed breathing, coma, or death; it can lead to physical dependence with continued use; it may cause severe skin reactions such as Stevens-Johnson syndrome; and it may cause serious harm to a fetus if taken during pregnancy. It should be used with caution in people with breathing, liver, or age-related health concerns. Talk to your doctor or pharmacist about the full range of possible side effects for your situation.
Is phenobarbital a barbiturate or benzodiazepine?
Phenobarbital is a barbiturate, not a benzodiazepine. It belongs to the barbiturate class of medications, which work differently in the brain than benzodiazepines like diazepam or lorazepam, even though both classes are used for some overlapping purposes such as seizure control.
How much does Phenobarbital cost without insurance?
The price of Phenobarbital without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Phenobarbital?
Common side effects of Phenobarbital may include: Hives or severe skin rash, Swelling of eyelids or face, Severe drowsiness, confusion, or slurred speech, Shortness of breath or trouble breathing, Uncontrollable eye movements. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Phenobarbital?
Generic versions may be available for Phenobarbital. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Phenobarbital on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Phenobarbital?
The cheapest pharmacy for Phenobarbital depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Phenobarbital near you.

Phenobarbital Coupons & Prices

PHENobarbital 16.2MG

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Phenobarbital Tablet — prescription drug image
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Phenobarbital 64.8mg (30)
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Compounded GLP-1 medications are not FDA-approved and are prepared by state-licensed compounding pharmacies. They are not affiliated with, endorsed by, or equivalent to any brand-name medication or manufacturer. Prescription required; eligibility is determined by a licensed provider. Prices are estimates and may vary.

Phenobarbital prices by dosage

Lowest cash price with a free Rx.com coupon vs. the average retail price.

Dosage Quantity Retail price Rx.com price
15mg · Tablet 60 $21.49
16.2mg · Tablet 60 $30.59 $26.07
30mg · Tablet 60 $22.79 $14.90
32.4mg · Tablet 60 $46.59 $27.33
60mg · Tablet 60 $34.37 $17.69
64.8mg · Tablet 60 $46.39 $30.89
97.2mg · Tablet 60 $334.49 $36.21
100mg · Tablet 60 $35.19 $23.39

Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.

Looking for a phenobarbital coupon? Phenobarbital is a long-established generic barbiturate, but the price you're quoted for it can still swing a lot from one pharmacy to the next — which is exactly where comparing matters. Rx.com checks pricing across 60,000+ pharmacies so you can enter your ZIP above and see today's price near you before you fill.

What is phenobarbital and how does it work?

Phenobarbital is a barbiturate that works as an anticonvulsant and sedative-hypnotic. It's FDA-approved to help control generalized tonic-clonic (grand mal) and partial seizures, and for emergency control of certain acute convulsive episodes, such as those associated with status epilepticus, eclampsia, meningitis, tetanus, or toxic reactions to strychnine or local anesthetics. It's also FDA-labeled as a sedative for daytime sedation and as part of pre-anesthetic sedation. Outside of its approved uses, clinicians also use phenobarbital for neonatal seizures and in phenobarbital-based protocols for alcohol or benzodiazepine withdrawal.

There is no widely marketed brand-name version of oral or standard injectable phenobarbital in the US today — it's essentially a generic-only medication. (An older brand, Luminal, is discontinued. A separate, newer branded IV product called SEZABY, formulated specifically for neonatal seizures, is a distinct product from the generic form most people are prescribed.)

Phenobarbital cost without insurance

Phenobarbital is generic, and generic status alone doesn't guarantee a consistent price — cash prices for the same generic drug can differ substantially depending on which pharmacy fills it, even within the same city. That's true for phenobarbital too, so it's worth comparing before you pick a pharmacy rather than assuming your usual one has the best price.

There is currently no manufacturer savings card for phenobarbital. Enter your ZIP code above to compare prices at pharmacies near you and see today's price.

Phenobarbital vs. other seizure and sedative medications

Phenobarbital is one of several medications used to manage seizures. Other commonly prescribed anticonvulsants include levetiracetam, phenytoin, and gabapentin, each with its own dosing profile and side-effect considerations. Benzodiazepines such as clonazepam, diazepam, and lorazepam are also used for seizure-related and sedation purposes in some situations. Which medication is right depends on the type of seizures or condition being treated, and switching between these classes should only be done with a prescriber's guidance — they are not interchangeable.

Phenobarbital safety information

Phenobarbital is a Schedule IV controlled substance. Taking it together with opioids or other central nervous system depressants can cause profound sedation, slowed or stopped breathing, coma, or death. With continued use, the body can become physically dependent, and stopping abruptly can trigger a serious, potentially life-threatening withdrawal, including seizures — phenobarbital should only be tapered off under a doctor's supervision, never stopped suddenly on your own. It is habit-forming with a potential for misuse, may cause serious harm to a fetus if used during pregnancy, and can rarely cause severe skin reactions such as Stevens-Johnson syndrome. It should be used cautiously in people with breathing problems, liver impairment, or in older or debilitated patients.

This is general information, not medical advice — talk with your doctor or pharmacist about whether phenobarbital is right for you and how to take it safely.

Sources & accuracy

This Phenobarbital information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Phenobarbital on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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