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Polysporin Tube Of Ointment — prescription drug image

Polysporin

Polysporin

What is Polysporin?

Polysporin is a first aid antibiotic ointment that helps prevent infections in minor cuts, scrapes, and burns. It contains two active ingredients that work together to fight bacteria and promote healing.

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What is Polysporin ?

Polysporin is a first aid antibiotic ointment that helps prevent infections in minor cuts, scrapes, and burns. It contains two active ingredients that work together to fight bacteria and promote healing.

  • Signs of wound or skin infection: increasing pain, redness, swelling, or drainage of fluid or pus that is cloudy, brown, green, or foul-smelling.
  • New or worsening skin rash.
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • New or worsening redness, burning, itching, or swelling in the area where the medicine is applied.
  • Unexplained fever.
  • Some antibacterial skin medicines may cause discoloring of the skin, hair, nails, or may stain clothing.
  • Make sure any doctor who treats you knows that you are using this medicine. Some antibacterial skin medicines may cause problems with certain medical tests.
  • Make sure your doctor knows if you are pregnant or breast feeding, or if you have a tuberculosis infection of the skin. Make sure your doctor knows if you have had an allergic reaction to any antibiotic or topical medicine, such as hydrocortisone, iodochlorhydroxyquin, bacitracin, neomycin, or polymyxin B.
  • Call your doctor if your symptoms do not improve or if they get worse.
  • Unexplained fever.
What is Polysporin used for?

Polysporin is an over-the-counter first-aid antibiotic ointment used to help prevent infection in minor cuts, scrapes, and burns. It combines bacitracin and polymyxin B. It is for external use only and does not treat deep or serious wounds. A separate prescription ophthalmic version is used for superficial bacterial eye infections.

What is the difference between Polysporin and Neosporin?

Polysporin is a "double antibiotic" ointment with bacitracin and polymyxin B, while Neosporin is a "triple antibiotic" that also contains neomycin. Because neomycin is a common cause of skin allergy, Polysporin is often chosen by people who are allergic or sensitive to neomycin.

Can I use Polysporin on my face?

Polysporin skin ointment is for external use on minor cuts, scrapes, and burns, and people sometimes use it on small areas of the face, but keep it away from the eyes. Do not use it over large or deep wounds. If you are unsure about using it near the eyes, nose, or mouth, ask your provider or pharmacist first.

Is Polysporin safe to use in or around the eyes?

The skin ointment is not for use in the eyes. There is a separate prescription ophthalmic (eye) ointment made specifically for the eyes; do not substitute the skin product for it. If you have an eye infection or need something used around the eyes, see a healthcare provider.

How long should you use Polysporin on a cut?

It is generally used short-term while a minor wound heals. Stop use and check with a healthcare provider if the condition persists or gets worse after about a week, or if a rash or allergic reaction develops. Prolonged use is not recommended because it may allow non-susceptible germs to overgrow.

How much does Polysporin 28.3GM of 500-10000UNIT/GM cost without insurance?
The price of Polysporin 28.3GM of 500-10000UNIT/GM without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save 60–90% off retail prices with a free Rx.com coupon.
What are the common side effects of Polysporin 28.3GM of 500-10000UNIT/GM?
Common side effects of Polysporin 28.3GM of 500-10000UNIT/GM may include: Signs of wound or skin infection: increasing pain, redness, swelling, or drainage of fluid or pus that is cloudy, brown, green, or foul-smelling., New or worsening skin rash., Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, New or worsening redness, burning, itching, or swelling in the area where the medicine is applied., Unexplained fever.. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Polysporin 28.3GM of 500-10000UNIT/GM?
Generic versions may be available for Polysporin 28.3GM of 500-10000UNIT/GM. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Polysporin 28.3GM of 500-10000UNIT/GM on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Polysporin 28.3GM of 500-10000UNIT/GM?
The cheapest pharmacy for Polysporin 28.3GM of 500-10000UNIT/GM depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Polysporin 28.3GM of 500-10000UNIT/GM near you.

Polysporin Coupons & Prices

Polysporin

Polysporin Tube Of Ointment — prescription drug image

No Prescription Needed

Polysporin is available over the counter — order online or pick up at a pharmacy near you.

Where to Buy Polysporin

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Looking for a Polysporin coupon? Polysporin is an over-the-counter "double antibiotic" first-aid ointment (bacitracin zinc and polymyxin B sulfate) used to help prevent infection in minor cuts, scrapes, and burns. Because it is neomycin-free, it is a common alternative for people who react to triple-antibiotic ointments. Even though it is sold without a prescription, some pharmacies price it lower with a free Rx.com discount coupon, or when your provider writes it as a prescription. Enter your ZIP above to see today's price at pharmacies near you.

What is Polysporin and how does it work?

Polysporin is a topical antibiotic ointment that combines two medicines: bacitracin (a polypeptide antibiotic) and polymyxin B (a polymyxin antibiotic). Together they help stop the growth of bacteria on the skin, which lowers the chance of infection while a minor wound heals. It is most often sold as Polysporin First Aid Antibiotic Ointment and is meant for external use only on minor cuts, scrapes, and burns.

A key difference from triple-antibiotic ointments is that Polysporin does not contain neomycin, so it is a frequent choice for people who are allergic or sensitive to neomycin. Note that a separate prescription ophthalmic (eye) ointment with bacitracin and polymyxin B also exists for superficial bacterial eye infections; that is a different product from the skin ointment and should only be used as directed by a provider. Polysporin does not treat deep or serious wounds.

How to save on Polysporin with an Rx.com coupon

Polysporin is available over the counter, so you can buy it off the shelf. But prices vary a lot from store to store, and some pharmacies ring it up cheaper when you present a free Rx.com discount coupon at the pharmacy counter, or when your provider writes it as a prescription. There is no manufacturer copay card for an OTC item like this, so the discount coupon is the simplest way to compare.

To check, enter your ZIP code above to see today's price at pharmacies near you and print, text, or show the coupon at checkout. Prices change, so it is worth comparing the shelf price against the couponed pharmacy price before you buy.

Polysporin vs. Neosporin and other alternatives

The most common comparison is Polysporin versus Neosporin. Both are first-aid antibiotic ointments, but Neosporin is a "triple antibiotic" that adds neomycin, while Polysporin is a "double antibiotic" with just bacitracin and polymyxin B. Because neomycin is a frequent cause of skin allergy, many people who react to Neosporin are steered toward Polysporin instead.

Related options your provider or pharmacist may mention include:

  • Bacitracin alone, a single-ingredient antibiotic ointment.
  • Neomycin, polymyxin B, and bacitracin, the triple-antibiotic combination.
  • Mupirocin, a prescription topical antibiotic used for certain skin infections.

A generic version of the double-antibiotic ointment is available, and it works the same as the Polysporin brand. Ask your pharmacist which option fits your needs and budget.

Safety and how to use it

Polysporin skin ointment is for external use only. Do not use it in the eyes, and do not apply it over large or deep wounds, puncture wounds, animal bites, or serious burns. Clean the area, apply a small amount one to three times a day as directed on the label, and you may cover it with a sterile bandage. Stop use and check with a healthcare provider if the condition persists or gets worse after about a week, or if a rash or other allergic reaction develops.

Contact allergic dermatitis to bacitracin and/or polymyxin B can occur, and rare cases of serious allergic reaction (anaphylaxis) to bacitracin have been reported. Prolonged use may also allow non-susceptible germs to overgrow. This is general information, not medical advice. Follow the package directions and talk with your provider or pharmacist about your specific situation, especially before using it on children or over a large area.

Sources & accuracy

This Polysporin information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Polysporin on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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