Prolia
Prolia 1ML of 60MG/ML
What is Prolia?
Prolia is an injection used to treat certain types of bone loss, including osteoporosis and bone damage from cancer. It helps strengthen bones and reduce the risk of fractures.Side Effects
- Severe bone, joint, or muscle pain
- Muscle spasms or twitching, numbness or tingling in your fingers, toes, or lips
- Pain or burning during urination, change in how much or how often you urinate
Warnings
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant before receiving this medicine. Use an effective form of birth control to keep from getting pregnant during treatment with this medicine and for 5 months after the last dose.
- Tell your doctor if you are breastfeeding, or if you have kidney disease, diabetes, gum disease, or a history of fractures. Tell your doctor if you have problems with your thyroid, parathyroid, or digestive system.
- This medicine may cause the following problems:Increased risk of broken thigh boneIncreased risk of infectionsSerious skin reactionsSevere bone, joint, or muscle pain
- Do not suddenly stop using this medicine without checking first with your doctor. Doing so may increase your risk for more fractures. Talk to your doctor about other medicines that you can take.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Prescription savings · · · ·
What is Prolia ?
Prolia is an injection used to treat certain types of bone loss, including osteoporosis and bone damage from cancer. It helps strengthen bones and reduce the risk of fractures.- Severe bone, joint, or muscle pain
- Muscle spasms or twitching, numbness or tingling in your fingers, toes, or lips
- Pain or burning during urination, change in how much or how often you urinate
- Fever, chills, cough, sore throat, body aches
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, red skin rash
- Chest pain, fast or uneven heartbeat, trouble breathing
- Lightheadedness, dizziness, fainting
- Pain, swelling, heavy feeling, or numbness in your mouth or jaw, loose teeth or other teeth problems
- Unusual pain in your thigh, groin, or hip
- Sudden and severe stomach pain, nausea, vomiting
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant before receiving this medicine. Use an effective form of birth control to keep from getting pregnant during treatment with this medicine and for 5 months after the last dose.
- Tell your doctor if you are breastfeeding, or if you have kidney disease, diabetes, gum disease, or a history of fractures. Tell your doctor if you have problems with your thyroid, parathyroid, or digestive system.
- This medicine may cause the following problems:Increased risk of broken thigh boneIncreased risk of infectionsSerious skin reactionsSevere bone, joint, or muscle pain
- Do not suddenly stop using this medicine without checking first with your doctor. Doing so may increase your risk for more fractures. Talk to your doctor about other medicines that you can take.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Pain, swelling, heavy feeling, or numbness in your mouth or jaw, loose teeth or other teeth problems
- This medicine can cause jaw problems. You must have regular dental exams while you are being treated with this medicine. Tell your dentist that you are receiving this medicine. Practice good oral hygiene.
- Severe bone, joint, or muscle pain
- Unusual pain in your thigh, groin, or hip
Prolia Coupons & Prices
Prolia 1ML of 60MG/ML
Weight-loss medication, prescribed online
Licensed U.S. providers · No insurance needed · Shipped to your door
Looking for a Prolia coupon? Prolia (denosumab) is a twice-yearly injection used to treat osteoporosis and build bone mass in adults at high risk for fracture. Whether you have commercial insurance, Medicare, or no coverage at all, an Rx.com cash coupon can help lower what you pay at the pharmacy. Enter your ZIP above to see today's price on denosumab in your area.
What is Prolia and how does it work?
Prolia is the brand name for denosumab, a human monoclonal antibody (IgG2) that works as a RANK ligand (RANKL) inhibitor. RANKL is a signal your body uses to activate the cells that break down bone. By blocking RANKL, Prolia slows bone breakdown (resorption), which helps preserve bone density and lower fracture risk. It is given as a 60 mg injection under the skin once every 6 months, usually by a healthcare professional.
Prolia is FDA-approved to treat postmenopausal women with osteoporosis at high risk for fracture, to increase bone mass in men with osteoporosis at high risk for fracture, and to treat glucocorticoid-induced (steroid-related) osteoporosis in men and women at high fracture risk. It is also approved to increase bone mass in men receiving androgen deprivation therapy for nonmetastatic prostate cancer and in women receiving adjuvant aromatase inhibitor therapy for breast cancer. Note that Xgeva is the same molecule, denosumab, but at a different dose and for cancer-related bone conditions; the two are not interchangeable and should never be used together.
Prolia cost: manufacturer savings card vs. Rx.com cash coupon
Amgen, which makes Prolia, offers an official manufacturer savings program described on its Prolia website (search "paying for Prolia"). Like most drugmaker copay cards, it is generally limited to people with commercial (private) insurance, and its terms, eligibility, and any caps vary and can change, so read the fine print. People with Medicare, Medicaid, or other government coverage typically are not eligible for a manufacturer copay card.
That is where an Rx.com cash coupon can help. Our coupon is a cash-price discount you can use if you are uninsured, if you have Medicare, or if the manufacturer card is declined or doesn't apply. Amgen also runs a patient assistance program (the Amgen SafetyNet Foundation) for qualifying patients who cannot afford their medication; ask your provider or pharmacist about it. To compare your options, enter your ZIP above to see today's Rx.com price on denosumab near you.
Is there a generic, and what are the alternatives?
Yes. FDA-approved denosumab biosimilars referencing Prolia are now available in the US (for example, Jubbonti and Wyost's Prolia-referenced counterpart), which can be a major savings lever compared with brand-name Prolia. Ask your pharmacist whether a denosumab biosimilar is stocked and appropriate for you, and enter your ZIP above to see current pricing.
Prolia is one of several osteoporosis treatments, and the right choice depends on your situation. Other options your doctor may discuss include oral bisphosphonates like Fosamax (alendronate), Actonel, and Boniva; the once-yearly IV bisphosphonate Reclast; and bone-building (anabolic) medicines such as Evenity and Forteo. This is general information, not medical advice; your provider can help you weigh which fits your fracture risk and health history.
Prolia safety: what to know
Prolia carries an FDA Boxed Warning for severe, potentially life-threatening low blood calcium (hypocalcemia) in patients with advanced chronic kidney disease, especially those on dialysis; kidney function and blood calcium should be checked and corrected before dosing and monitored afterward. Everyone taking Prolia should take enough calcium and vitamin D as directed. Prolia is not for use in pregnancy because it can harm the fetus.
Other serious risks noted in the label include multiple spine (vertebral) fractures that can occur if doses are stopped or delayed, so do not discontinue Prolia without your doctor transitioning you to another bone medicine; osteonecrosis (bone loss) of the jaw; unusual thigh-bone (atypical femur) fractures; serious infections, including of the skin and heart lining; and skin reactions. Tell your doctor about kidney problems, dental work, and any planned surgeries. This is a brief summary, not a substitute for talking with your healthcare provider about your personal risks.
This Prolia information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Prolia on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.