Spironolactone
Spironolactone 25MG
What is Spironolactone?
Aldactone is a potassium-sparing diuretic (water pill) drug used to treat edema and hypertension. The generic version of Aldactone is Spironolactone. On average Aldactone is priced at about $18 for a supply of 30, 25 mg tablets. Luckily, you can use our Rx.com savings offer to receive an Aldactone discount of up to 80% off the retail price at participating pharmacies near you.Side Effects
- Confusion, uneven heartbeat, trouble breathing, numbness or tingling in your hands, feet, or lips
- Lightheadedness, dizziness, drowsiness, fainting
- Dry mouth, increased thirst, muscle cramps, nausea, vomiting
Warnings
- Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding, or if you have kidney disease, liver disease, diabetes, gout, or trouble urinating.
- This medicine may cause the following problems:Low blood pressureKidney problemsElectrolyte imbalanceHigh uric acid and blood sugarGynecomastia (enlarged breast)
- This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
- Do not stop using the medicine without asking your doctor, even if you feel well. This medicine will not cure your high blood pressure, but it will help keep it in the normal range. You may have to take blood pressure medicine for the rest of your life.
- Tell any doctor or dentist who treats you that you are using this medicine.
Prescription savings · · · ·
What is Spironolactone ?
Aldactone is a potassium-sparing diuretic (water pill) drug used to treat edema and hypertension. The generic version of Aldactone is Spironolactone. On average Aldactone is priced at about $18 for a supply of 30, 25 mg tablets. Luckily, you can use our Rx.com savings offer to receive an Aldactone discount of up to 80% off the retail price at participating pharmacies near you.- Confusion, uneven heartbeat, trouble breathing, numbness or tingling in your hands, feet, or lips
- Lightheadedness, dizziness, drowsiness, fainting
- Dry mouth, increased thirst, muscle cramps, nausea, vomiting
- Blistering, peeling, red skin rash
- Muscle twitching
- Blood in your stools or dark stools, vomiting blood or material that looks like coffee grounds
- Increased hunger or thirst, change in how much or how often you urinate, unusual weight loss
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Unusual bleeding, bruising, or weakness
- Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding, or if you have kidney disease, liver disease, diabetes, gout, or trouble urinating.
- This medicine may cause the following problems:Low blood pressureKidney problemsElectrolyte imbalanceHigh uric acid and blood sugarGynecomastia (enlarged breast)
- This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
- Do not stop using the medicine without asking your doctor, even if you feel well. This medicine will not cure your high blood pressure, but it will help keep it in the normal range. You may have to take blood pressure medicine for the rest of your life.
- Tell any doctor or dentist who treats you that you are using this medicine.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Unusual bleeding, bruising, or weakness
Spironolactone Coupons & Prices
Spironolactone 25MG
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Looking for a spironolactone coupon? Spironolactone is a widely used generic prescription, so it is already one of the lower-cost options in its class, but the cash price can vary a lot from one pharmacy to the next. With Rx.com you can compare spironolactone prices across more than 60,000 pharmacies and get a free discount coupon to show your pharmacist. Enter your ZIP above to see today's price near you.
What is spironolactone and how does it work?
Spironolactone (sold under the brand names Aldactone and Carospir) is a potassium-sparing diuretic, also called an aldosterone receptor antagonist or mineralocorticoid receptor antagonist. It blocks the hormone aldosterone, which helps your body remove extra fluid and sodium while holding on to potassium. This lowers blood pressure and reduces swelling without wasting potassium the way many other water pills do.
It is FDA-approved to help treat heart failure (NYHA class III-IV, as add-on therapy to reduce the risk of death and hospitalization), high blood pressure, and edema (fluid buildup) from cirrhosis, nephrotic syndrome, or heart failure. It is also used to diagnose and treat primary hyperaldosteronism and to help manage low potassium (hypokalemia). Because it also has anti-androgen activity, spironolactone is very commonly prescribed off-label in dermatology and women's health.
Spironolactone cost and savings without insurance
Spironolactone is available as an FDA-approved generic, which is why it is typically an affordable medication. Even so, the cash price is not the same everywhere. Two pharmacies on the same street can list very different prices for the exact same prescription, so comparing before you fill genuinely matters. There is no manufacturer copay savings card for spironolactone because it is a low-cost generic.
If you are paying without insurance, or your plan does not cover it well, a free Rx.com discount coupon may bring the cash price down. Rx.com compares spironolactone prices across more than 60,000 U.S. pharmacies so you can find a lower price near you. Enter your ZIP above to see today's price and print or text yourself the coupon to show your pharmacist. The brand versions, Aldactone and Carospir, generally cost more than the generic.
Spironolactone alternatives and related diuretics
Spironolactone is one of several water pills, and the right choice depends on your condition and how your body handles potassium. Only your prescriber can decide what fits you, but these related medicines are often discussed alongside it:
- Eplerenone - another aldosterone receptor antagonist, often chosen when spironolactone's hormonal side effects are a concern (note: spironolactone and eplerenone should not be combined).
- Amiloride and Triamterene - other potassium-sparing diuretics.
- Hydrochlorothiazide - a thiazide diuretic commonly used for high blood pressure.
- Furosemide - a stronger loop diuretic used for more significant fluid retention.
All of these are available as generics. You can compare prices for each on Rx.com to see which is most affordable at your pharmacy.
Safety, side effects, and important warnings
Spironolactone carries a boxed warning because it was shown to cause tumors in chronic rat toxicity studies; it should not be used unnecessarily. The main safety concern is hyperkalemia (high potassium), which can be serious or even life-threatening. The risk is higher if you have kidney problems, diabetes, are older, or take ACE inhibitors, ARBs, potassium supplements, or salt substitutes. Your provider will usually check your potassium and kidney function while you take it, and you should avoid potassium-rich salt substitutes.
Other possible effects include low sodium, dehydration, dizziness, breast tenderness or enlargement (gynecomastia, related to dose and how long you take it), and menstrual changes. Spironolactone should not be used if you have high potassium, Addison's disease, no urine output (anuria), significant kidney impairment, or if you take eplerenone, and it should be avoided in pregnancy. This is general information, not medical advice; talk with your doctor or pharmacist about your own situation and any medicines you take.
This Spironolactone information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Spironolactone on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
Spironolactone — Articles & Guides
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.