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Systane Bottle — prescription drug image

Systane

Systane 15ML of 0.4-0.3%

What is Systane?

Systane is an eye drop solution used to relieve dryness and irritation in the eyes. It helps to provide moisture and comfort for those experiencing discomfort due to various environmental factors.

Prescription savings · · · ·

What is Systane ?

Systane is an eye drop solution used to relieve dryness and irritation in the eyes. It helps to provide moisture and comfort for those experiencing discomfort due to various environmental factors.

Source: MedlinePlus, U.S. National Library of Medicine

  • Changes in vision.
  • Eye pain, redness, or irritation that is not relieved by using this product.
  • See a doctor right away if you have an open wound in or near your eye, if your eye was burned with a chemical, or if you have a foreign object in your eye that you cannot rinse out.
  • Make sure your doctor knows if you have had an allergic reaction to any eye medicine or product in the past.
  • Do not use the medicine if it becomes discolored. Do not use the eye drops if the liquid has become cloudy.
What is Systane used for?
Systane is an over-the-counter lubricant eye drop used to temporarily relieve the burning, stinging, and irritation caused by dry eyes. It also helps protect against further irritation and eases discomfort from minor irritations such as wind or sun. Its demulcent ingredients coat and lubricate the surface of the eye.
How often can you use Systane eye drops?
Follow the directions on the product label, since dosing can vary by formulation. If your dry eye symptoms continue, worsen, or last more than 72 hours, or if you have eye pain or vision changes, stop use and ask a doctor. Your eye doctor or pharmacist can advise on how often is appropriate for you.
Can you use Systane with contact lenses?
Whether a specific Systane product can be used with contact lenses depends on that formulation, so always read the label of the exact product you have. If you are unsure, ask your eye doctor or pharmacist before using it with contacts.
What is the difference between Systane Ultra, Complete, and Balance?
The formulations target different types of dry eye. Systane Ultra is aimed at aqueous-deficient (tear-poor) dry eye, Systane Complete is designed for evaporative or mixed dry eye, and Systane Balance targets dry eye associated with Meibomian gland dysfunction. Your eye doctor can help you pick the one that best fits your symptoms.
Are there any side effects of Systane eye drops?
Systane may cause temporary blurred vision or a mild, brief burning or stinging when you put it in. Stop use and ask a doctor if you experience eye pain, changes in vision, continued redness or irritation, or if the condition worsens or persists more than 72 hours. Do not use the product if the solution changes color or becomes cloudy, or if you are sensitive to any ingredient.
How much does Systane cost without insurance?
The price of Systane without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Systane?
Common side effects of Systane may include: Changes in vision., Eye pain, redness, or irritation that is not relieved by using this product.. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Systane?
Generic versions may be available for Systane. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Systane on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Systane?
The cheapest pharmacy for Systane depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Systane near you.

Systane Coupons & Eye Drop Prices

Systane 15ML of 0.4-0.3%

Systane Bottle — prescription drug image

No Prescription Needed

Systane is available over the counter — order online or pick up at a pharmacy near you.

Where to Buy Systane

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Looking for a Systane coupon? Systane is a popular over-the-counter (OTC) lubricant eye drop from Alcon used to relieve the burning, stinging, and irritation of dry eyes. Because it is available without a prescription, prices can vary from store to store. Enter your ZIP above to see today's price and print or show an Rx.com coupon at the pharmacy counter, where some shoppers find OTC items cost less than the shelf price.

What is Systane and how does it work?

Systane is an over-the-counter ophthalmic lubricant, often called an "artificial tear." It temporarily relieves burning, stinging, and irritation caused by dry eyes, and helps protect against further irritation or discomfort from minor irritations such as exposure to wind or sun. The active demulcents (commonly polyethylene glycol 400 0.4% and propylene glycol 0.3%, with HP-guar as a gelling agent) coat and lubricate the surface of the eye to keep it moist and comfortable.

Systane comes in several formulations for different types of dry eye. Systane Ultra targets aqueous-deficient (tear-poor) dry eye, Systane Complete is designed for evaporative or mixed dry eye, and Systane Balance is aimed at dry eye linked to Meibomian gland dysfunction. Other options in the family include Systane Hydration, Systane Gel Drops, Systane Nighttime, and Systane PRO.

How to save on Systane with an Rx.com coupon

Systane is sold OTC, so you do not need a prescription to buy it. Prices still differ by pharmacy and location, and some OTC eye drops cost less with a coupon or when your provider writes them as a prescription. Enter your ZIP code above to see today's price near you and get a free Rx.com coupon to show at the counter. There is nothing to sign up for, and it never expires.

Alcon, the maker of Systane, also offers its own manufacturer savings on the official Systane website at systane.myalcon.com/coupons. Terms, eligibility, and any offer amounts are set by the manufacturer and can change, so check that page directly for current details. Compare both options to find the lower price on the day you buy.

Systane alternatives and how it compares

Systane is one of many artificial tear products. Other OTC lubricant eye drops that work in a similar way include Refresh Tears, Refresh, GenTeal, and Blink Tears. These are all available without a prescription, and the best choice often comes down to your type of dry eye and personal preference.

For chronic or moderate-to-severe dry eye that does not improve with artificial tears, an eye doctor may prescribe a medication rather than an OTC drop. Prescription options include Restasis, Xiidra, and Cequa. These treat the underlying condition differently than a lubricant and require a prescription. Talk with your provider about which approach fits your situation. This information is not medical advice.

Safety and how to use Systane

Systane is for external, ophthalmic (eye) use only. Do not inject or swallow it. Do not use the product if the solution changes color or becomes cloudy, or if you are sensitive to any ingredient. To avoid contamination, do not touch the dropper or container tip to your eye or any surface, and replace the cap after each use. Keep it out of reach of children.

Systane may cause temporary blurred vision or a mild, brief burning or stinging when you put it in. Stop use and ask a doctor if you have eye pain, changes in vision, continued redness or irritation, or if your condition worsens or lasts more than 72 hours. Systane has no boxed warning. This is general information, not medical advice, so follow the label and talk with your eye doctor or pharmacist about how often to use it and whether it is right for you.

Sources & accuracy

This Systane information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Systane on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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