Losartan Potassium-Hctz
Losartan Potassium-HCTZ 100-25MG
What is Losartan Potassium-Hctz?
Hyzaar is a combination of two medications that work together to treat high blood pressure and lower the chance of stroke. Hydrochlorothiazide/losartan is the generic version of Hyzaar. Hyzaar oral tablets (100 mg/25 mg) average around $207 for a supply of 30 tablets. To help save on Rx.com costs and incur instant savings, bring your free Rx.com coupon to your local pharmacy when picking up your prescription.Side Effects
- Confusion, weakness, trouble breathing, numbness in your hands, feet, or lips
- Fast, pounding, or uneven heartbeat
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Warnings
- It is not safe to take this medicine during pregnancy, especially in your second or third trimester. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease (including cirrhosis), heart failure, diabetes, gout, high cholesterol, lupus, trouble urinating, or a history of asthma or allergies.
- This medicine may cause the following problems: Kidney problemsLow or high levels of minerals in your blood, including potassium and sodiumEye or vision problems, including glaucomaIncreased risk for skin cancer
- This medicine could lower your blood pressure too much, especially when you first use it or if you are dehydrated. Stand or sit up slowly if you feel dizzy or lightheaded. Do not drive or do anything dangerous until you know how this medicine affects you.
- Do not stop using this medicine without asking your doctor, even if you feel well. This medicine will not cure your high blood pressure, but it will help keep it in normal range. You may have to take blood pressure medicine for the rest of your life.
Prescription savings · · · ·
What is Losartan Potassium-Hctz ?
Hyzaar is a combination of two medications that work together to treat high blood pressure and lower the chance of stroke. Hydrochlorothiazide/losartan is the generic version of Hyzaar. Hyzaar oral tablets (100 mg/25 mg) average around $207 for a supply of 30 tablets. To help save on Rx.com costs and incur instant savings, bring your free Rx.com coupon to your local pharmacy when picking up your prescription.- Confusion, weakness, trouble breathing, numbness in your hands, feet, or lips
- Fast, pounding, or uneven heartbeat
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Dry mouth, increased thirst, muscle twitching or cramps, nausea, vomiting
- Lightheadedness, dizziness, fainting
- Eye pain, vision changes, seeing halos around lights
- Change in how much or how often you urinate, bloody urine, lower back or side pain, rapid weight gain, swelling in your hands, ankles, or feet
- Sores, reddish patch or irritated area, shiny bump, pink growth, or white, yellow or waxy scar-like area on the skin
- It is not safe to take this medicine during pregnancy, especially in your second or third trimester. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease (including cirrhosis), heart failure, diabetes, gout, high cholesterol, lupus, trouble urinating, or a history of asthma or allergies.
- This medicine may cause the following problems: Kidney problemsLow or high levels of minerals in your blood, including potassium and sodiumEye or vision problems, including glaucomaIncreased risk for skin cancer
- This medicine could lower your blood pressure too much, especially when you first use it or if you are dehydrated. Stand or sit up slowly if you feel dizzy or lightheaded. Do not drive or do anything dangerous until you know how this medicine affects you.
- Do not stop using this medicine without asking your doctor, even if you feel well. This medicine will not cure your high blood pressure, but it will help keep it in normal range. You may have to take blood pressure medicine for the rest of your life.
- This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Losartan Potassium-Hctz Coupons & Prices
Losartan Potassium-HCTZ 100-25MG
Weight-loss medication, prescribed online
Licensed U.S. providers · No insurance needed · Shipped to your door
Losartan Potassium-Hctz prices by dosage
Lowest cash price with a free Rx.com coupon vs. the average retail price.
| Dosage | Quantity | Retail price | Rx.com price |
|---|---|---|---|
| 50-12.5mg · Tablet | 90 | $156.99 | $10.00 |
| 100-12.5mg · Tablet | 90 | $243.00 | $19.84 |
| 100-25mg · Tablet | 90 | $236.99 | $18.96 |
Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.
Looking for a losartan-potassium-hctz coupon? This combination blood pressure medication (brand name Hyzaar) is available as a low-cost generic, but the cash price can vary widely from one pharmacy to the next. Rx.com compares live prices across more than 60,000 U.S. pharmacies so you can enter your ZIP above and see today's price near you — no insurance required, and often less than what you would pay at the counter.
What is losartan-hydrochlorothiazide and how does it work?
Losartan potassium / hydrochlorothiazide is a fixed-dose combination of two blood pressure medicines in a single tablet. Losartan is an angiotensin II receptor blocker (ARB) that relaxes blood vessels, while hydrochlorothiazide (HCTZ) is a thiazide diuretic, or "water pill," that helps your body clear extra salt and fluid. Together they lower blood pressure more than either drug alone.
It is FDA-approved to treat hypertension (high blood pressure), usually as a step up when a single medicine does not control blood pressure well enough, or as initial therapy in people who are likely to need more than one drug. It is also approved to reduce the risk of stroke in patients who have high blood pressure along with left ventricular hypertrophy (an enlarged heart wall), though this benefit may not apply to Black patients. It is generally not used as the very first medicine for most people with high blood pressure.
Cost of losartan-HCTZ without insurance
Losartan-hydrochlorothiazide is already an inexpensive generic, which is good news if you are paying cash. Even so, the price is not the same everywhere — different pharmacies set very different cash prices for the exact same tablet, so it pays to compare before you fill. There is no manufacturer savings card for this generic, so a pharmacy discount price is usually your best route without insurance.
Enter your ZIP above to see today's price at pharmacies near you. Rx.com checks more than 60,000 pharmacies and shows the discounted cash price side by side, so you can pick the lowest one and bring the coupon to the counter.
Related drugs and alternatives
If your prescription is written differently, or your provider is weighing other options, these related medicines may be relevant. Never switch or stop a blood pressure medicine on your own — talk with your prescriber first.
- Losartan — the ARB component on its own, without the diuretic.
- Hydrochlorothiazide — the thiazide diuretic component on its own.
- Hyzaar — the brand-name version of this same losartan-HCTZ combination.
- Valsartan-hydrochlorothiazide — a similar ARB-plus-diuretic combination using a different ARB.
- Lisinopril-hydrochlorothiazide — an ACE-inhibitor-plus-diuretic combination.
Because Hyzaar and its generic contain the same active ingredients, most people can use the generic and compare its price above.
Important safety information
This medication carries a boxed warning for fetal toxicity: drugs that act on the renin-angiotensin system, like losartan, can cause injury or death to a developing baby. If you become pregnant or are planning pregnancy, tell your provider right away and stop the medicine as soon as pregnancy is detected. Other important risks include low blood pressure (especially if you are dehydrated or low on salt), changes in potassium levels (losartan can raise potassium while HCTZ can lower it), effects on kidney function, and, rarely, angioedema (swelling) or sudden eye problems such as acute angle-closure glaucoma. Long-term use of hydrochlorothiazide has been linked to a higher risk of non-melanoma skin cancer, so protect your skin from the sun and report new skin changes.
HCTZ can also affect blood sugar, cholesterol, and uric acid, and may worsen gout. This medicine should generally not be combined with aliskiren in people with diabetes, and combining multiple drugs that block the renin-angiotensin system needs caution. This is general information, not medical advice — talk with your doctor or pharmacist about your full health history and any other medicines or supplements you take.
This Losartan Potassium-Hctz information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Losartan Potassium-Hctz on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.