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Niacin Er

Niacin ER

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What is Niacin Er?

Niacin ER (extended-release) is a form of vitamin B3 used primarily to treat niacin deficiency and to help lower cholesterol and triglyceride levels in the blood. It works by reducing the production of certain fatty acids and boosting levels of high-density lipoprotein (HDL), or "good" cholesterol. Extended-release formulations of niacin release the active ingredient gradually, minimizing side effects such as flushing while maintaining its efficacy in lipid management.

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What is Niacin Er ?

Niacin ER (extended-release) is a form of vitamin B3 used primarily to treat niacin deficiency and to help lower cholesterol and triglyceride levels in the blood. It works by reducing the production of certain fatty acids and boosting levels of high-density lipoprotein (HDL), or "good" cholesterol. Extended-release formulations of niacin release the active ingredient gradually, minimizing side effects such as flushing while maintaining its efficacy in lipid management.

  • Unusual bleeding or bruising
  • Muscle pain, tenderness, or weakness
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • If you need to stop taking extended-release niacin, even for a short time, talk to your doctor before you start taking it again. You may need to start back on a lower dose.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • This medicine may make you dizzy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Stand or sit up slowly.
  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Do not breastfeed during treatment with this medicine.
  • Tell your doctor if you have liver disease, kidney disease, diabetes, gout, heart disease, angina, low blood pressure, thyroid problems, bleeding problems, or stomach ulcers.
  • This medicine may cause the following problems:Liver problemsRhabdomyolysis (serious muscle problem when used with statin medicine)High blood sugar levels
What is niacin ER (extended-release niacin) used for?

Niacin ER is a prescription lipid medicine used along with diet to lower total cholesterol, LDL (bad) cholesterol, apolipoprotein B and triglycerides, and to raise HDL (good) cholesterol, in adults with primary hyperlipidemia or mixed dyslipidemia. It is also approved to reduce the risk of a repeat nonfatal heart attack in people who have had a heart attack and have high cholesterol; to slow or reverse atherosclerosis when used with a bile acid binding resin in people with coronary artery disease and high cholesterol; and to treat adults with very high triglycerides (Type IV and V hyperlipidemia) who are at risk of pancreatitis and have not responded adequately to diet.

Why does niacin ER cause flushing, and how can I prevent it?

Flushing (warmth, redness, itching, or tingling, usually in the face and upper body) is the most common side effect of niacin at lipid-lowering doses. It is uncomfortable rather than dangerous for most people, and it often lessens as your body adjusts. Common steps that help: take the dose at bedtime after a low-fat snack, start at a low dose and increase slowly exactly as your prescriber directs, avoid alcohol, hot beverages, and spicy foods around the time of your dose, and, if your prescriber agrees, take aspirin (up to 325 mg) about 30 minutes before the dose. Do not change your dose on your own; ask your doctor or pharmacist first.

Is prescription niacin ER the same as over-the-counter niacin supplements?

No. Prescription niacin extended-release is an FDA-approved lipid-lowering drug with a specific release profile and a required liver-monitoring plan. Over-the-counter niacin and so-called no-flush niacin are dietary supplements, not FDA-approved cholesterol medicines, and they are not equivalent substitutes. Different niacin products are also not interchangeable milligram-for-milligram: substituting an extended-release or sustained-release product for immediate-release niacin at the same dose has caused severe liver injury. Never swap products on your own; talk to your prescriber or pharmacist.

Do you have to take niacin ER at bedtime?

Niacin ER is typically taken once a day at bedtime, after a low-fat snack, because that timing helps you sleep through the worst of the flushing. Tablets must be swallowed whole and never broken, crushed, or chewed. Follow the exact directions on your prescription label, and ask your pharmacist if you are unsure about timing, food, or a missed dose.

Is niacin ER still recommended if I'm already on a statin?

Generally no, not as a routine add-on. Two large randomized trials, AIM-HIGH and HPS2-THRIVE, found no additional reduction in cardiovascular events when niacin ER was added to statin therapy, and they found more serious adverse events. The FDA withdrew approval of the indications for niacin ER used together with simvastatin or lovastatin in 2016, and current guidelines no longer recommend adding niacin to a statin routinely. Combining the two also raises the risk of muscle injury. Only your prescriber can decide whether niacin ER makes sense in your specific situation, so do not start or stop it on your own.

How much does Niacin ER 100 Tablets Extended Release cost without insurance?
The price of Niacin ER 100 Tablets Extended Release without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save 60–90% off retail prices with a free Rx.com coupon.
What are the common side effects of Niacin ER 100 Tablets Extended Release?
Common side effects of Niacin ER 100 Tablets Extended Release may include: Unusual bleeding or bruising, Muscle pain, tenderness, or weakness, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Niacin ER 100 Tablets Extended Release?
Generic versions may be available for Niacin ER 100 Tablets Extended Release. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Niacin ER 100 Tablets Extended Release on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Niacin ER 100 Tablets Extended Release?
The cheapest pharmacy for Niacin ER 100 Tablets Extended Release depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Niacin ER 100 Tablets Extended Release near you.

Niacin Er Coupons & Prices

Niacin ER

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Niacin Er Bottle — prescription drug image
Prescription
Niacin Er 100 capsules extended release (0.3)
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Looking for a niacin ER coupon? Rx.com gives you a free niacin extended-release (nicotinic acid ER) discount coupon you can use at the pharmacy counter, with no insurance and no membership required. Niacin ER is a prescription cholesterol and triglyceride medicine that is available as a generic, so it is usually one of the lower-cost lipid drugs to fill with cash. Even so, the cash price for the same tablet strength can vary a lot from one pharmacy to the next, which is exactly why comparing is worth the two minutes. Enter your ZIP code above to see today's niacin ER price at pharmacies near you, compared across more than 60,000 U.S. pharmacies, then show the coupon on your phone or print it.

What is niacin ER and how does it work?

Niacin extended-release (nicotinic acid ER) is a prescription antihyperlipidemic (antilipemic) medicine. Niacin is a B vitamin, but at the much higher, pharmacologic doses used in this prescription product it acts as a lipid-lowering drug: it lowers total cholesterol, LDL ("bad") cholesterol, apolipoprotein B and triglycerides, and it raises HDL ("good") cholesterol. The extended-release tablet is designed to release the niacin slowly over several hours, which is why it must be swallowed whole and never broken, crushed, or chewed.

The FDA-approved uses, always as an add-on to diet, are: lowering elevated total cholesterol, LDL-C, Apo B and triglycerides and raising HDL-C in adults with primary hyperlipidemia and mixed dyslipidemia; reducing the risk of a repeat nonfatal heart attack in people with a prior heart attack and high cholesterol; slowing or reversing the progression of atherosclerosis, in combination with a bile acid binding resin, in people with a history of coronary artery disease and high cholesterol; and treating adults with very high triglycerides (Type IV and V hyperlipidemia) who are at risk of pancreatitis and have not responded well enough to diet alone. Note that the brand Niaspan is no longer marketed in the U.S., and the old niacin ER combination products Advicor and Simcor have been withdrawn. Prescription niacin ER is a different product from the over-the-counter niacin and "no-flush niacin" supplements sold on store shelves, which are dietary supplements and are not FDA-approved cholesterol drugs.

Niacin ER cost without insurance, and how the coupon helps

Niacin ER is available as an FDA-approved generic, and the brand-name version is gone from the U.S. market, so you are almost always filling the generic. Generics of an older drug like this are typically inexpensive compared with newer lipid medicines. What surprises people is the spread: cash prices for the exact same strength and quantity can differ substantially between a big chain, a grocery pharmacy, and an independent down the street, because each pharmacy sets its own cash price. That is the single biggest reason to compare before you fill rather than defaulting to the pharmacy you have always used.

Rx.com's niacin ER coupon is free to use, works whether or not you have insurance, and is not insurance itself. If you are uninsured or your plan has a high deductible, the coupon price is often the price you would simply pay out of pocket. If you do have coverage, it is still worth checking the coupon price against your copay and using whichever is lower (you cannot combine the two on the same fill). There is no manufacturer savings card for niacin ER, since the brand is discontinued. Enter your ZIP above to see today's price at pharmacies near you, and ask your pharmacist for the coupon price by name before they run it through your insurance.

Niacin ER vs. other cholesterol and triglyceride medicines

Niacin ER is not a statin and does not work like one. For lowering LDL cholesterol and reducing cardiovascular risk, statins such as atorvastatin, simvastatin and rosuvastatin are the mainstay of treatment, and ezetimibe is often added to a statin. For very high triglycerides, prescribers commonly consider fibrates such as fenofibrate or gemfibrozil, or omega-3-acid ethyl esters. All of these are available as generics, and all of them have their own cash-price spread across pharmacies, so it is worth comparing whichever one you are prescribed.

One important piece of context: two large randomized trials, AIM-HIGH and HPS2-THRIVE, found no additional reduction in cardiovascular events when niacin ER was added on top of statin therapy, along with more serious side effects. Because of those results, the FDA withdrew approval of the indications for niacin ER taken together with simvastatin or lovastatin (Federal Register, April 18, 2016), and guidelines no longer recommend routinely adding niacin to a statin. Your prescriber is the right person to decide whether niacin ER still has a role in your particular case. This page is information, not medical advice, and is not a recommendation to start, stop, or switch any medicine.

Niacin ER safety, side effects, and flushing

Niacin ER does not carry a boxed warning. It should not be used if you have active liver disease or unexplained persistent elevations in liver enzymes, active peptic ulcer disease, arterial bleeding, or a known allergy to niacin. Serious, occasionally severe liver injury has occurred, most often when someone substituted a sustained- or extended-release niacin for immediate-release niacin at the same milligram dose. These products are not interchangeable milligram-for-milligram, so never swap one for the other on your own. Your prescriber should check liver enzymes before you start, roughly every 6 to 12 weeks during the first year, and periodically after that. Niacin ER can also raise blood sugar (important if you have diabetes or prediabetes) and uric acid, which can bring on gout, and it raises the risk of muscle problems including myopathy and rhabdomyolysis when taken with a statin, especially in older adults and in people with diabetes, kidney impairment, or untreated hypothyroidism. Use caution if you have a history of peptic ulcer or take an anticoagulant. It has not been established as safe at lipid-lowering doses in pregnancy or breastfeeding.

Flushing is by far the most common side effect: warmth, redness, itching, or tingling, usually of the face and upper body. It is uncomfortable but generally not dangerous, and it tends to ease over time. Common ways to reduce it include taking the dose at bedtime after a low-fat snack, starting at a low dose and increasing slowly as directed, avoiding alcohol, hot drinks, and spicy food around the time of your dose, and, if your prescriber agrees, taking aspirin (up to 325 mg) about 30 minutes beforehand. Talk with your doctor or pharmacist about any side effect that worries you, and get medical attention promptly for unexplained muscle pain or weakness, yellowing of the skin or eyes, dark urine, or persistent stomach pain.

Sources & accuracy

This Niacin Er information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Niacin Er on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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