Voriconazole Coupons & Prices

Looking for a voriconazole coupon? Voriconazole is the generic form of Vfend, a prescription triazole antifungal used to treat serious fungal infections such as invasive aspergillosis and certain Candida infections. Because the generic is widely made (Amneal, Mylan/Viatris, Ajanta, Fosun and others), the cash price is usually far lower than the brand, but what you actually pay can still swing a lot from one pharmacy to the next, even across the street. Rx.com compares cash prices at more than 60,000 U.S. pharmacies and gives you a free discount coupon you can show at the counter, with no membership or insurance required. Enter your ZIP code above to see today's voriconazole price near you and print, text or email the coupon.

What is voriconazole and how does it work?

Voriconazole is a triazole (azole) antifungal. It blocks a fungal enzyme system, cytochrome P450-dependent 14-alpha-lanosterol demethylation, that fungi need to make ergosterol, a key building block of the fungal cell membrane. Without ergosterol, the fungal cell membrane cannot work properly and the fungus cannot grow. It is sold as the brand Vfend and Vfend IV (Pfizer/Roerig) and as generic voriconazole.

The FDA has approved voriconazole for adults and children 2 years and older to treat:

• Invasive aspergillosis
• Candidemia in patients who are not neutropenic, and deep-tissue Candida infections of the skin, abdomen, kidney, bladder wall and wounds
• Esophageal candidiasis
• Serious infections caused by Scedosporium apiospermum and Fusarium species in people who cannot tolerate, or did not respond to, other antifungal therapy

It comes as 50 mg and 200 mg tablets, an oral suspension (40 mg/mL) and an intravenous injection given in a hospital or infusion clinic. Your prescriber decides the dose and the form; do not change either on your own.

Voriconazole cost without insurance, and how the coupon helps

Voriconazole has an FDA-approved generic, and generics are typically the lowest-cost way to fill this prescription. That said, cash prices for generic voriconazole are not set nationally. Each pharmacy chooses its own retail price, so two pharmacies in the same ZIP code can quote very different numbers for the exact same tablets, strength and quantity. That is why comparing before you fill is worth the two minutes it takes.

If you are paying cash, uninsured, in a deductible phase, or your plan does not cover this drug, use the Rx.com discount card. Enter your ZIP above to see today's price at pharmacies near you, then bring the free coupon to the counter. A few practical tips: ask the pharmacist to price the tablet strength your prescriber intended (50 mg versus 200 mg tablets can price differently), check the price for the full days' supply your prescriber wrote, and confirm the pharmacy actually stocks it, since voriconazole is a specialty-type antifungal that smaller pharmacies may need to order. There is no manufacturer copay savings card for generic voriconazole; Pfizer runs a patient assistance program through its official Pfizer RxPathways site, and eligibility rules and terms vary, so check directly with them. Discount coupons cannot be combined with insurance on the same fill, but you may use whichever is cheaper.

Voriconazole vs. other antifungals

Voriconazole is not interchangeable with other azoles. Each one covers a different range of fungi, and only your prescriber can choose the right one for the organism you are being treated for:

• Vfend is the brand-name version of the same drug, voriconazole. Generic voriconazole is FDA-approved and substitutable for it.
• Fluconazole is another triazole, used mainly for Candida infections and cryptococcal meningitis. It does not reliably cover Aspergillus.
• Itraconazole and posaconazole are triazoles with mold activity that are used in different situations and have their own dosing, absorption and interaction issues.
• Terbinafine is an allylamine antifungal used for nail and skin fungal infections, not for invasive fungal disease.
• Ketoconazole is an older azole whose oral use is now limited because of liver and interaction concerns.

If cost is the reason you are considering a switch, talk to your prescriber first, then price the specific drug they approve. Do not substitute one antifungal for another on your own.

Safety, side effects and interactions

Voriconazole does not carry an FDA boxed warning, but its label includes several important warnings. Liver injury can occur, including hepatitis, cholestasis and, rarely, fatal liver failure, so your provider should check liver blood tests before you start and at least weekly during the first month. It can prolong the QT interval and, rarely, trigger serious heart rhythm problems; potassium, magnesium and calcium levels should be corrected before dosing. Visual disturbances are common and usually temporary. Serious skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS) have been reported, so tell your provider right away about any rash. Voriconazole also causes photosensitivity, and with long-term use has been linked to squamous cell skin cancer and melanoma, so sun protection matters. Other label warnings include kidney injury (especially with the IV form, whose SBECD vehicle builds up in kidney impairment), infusion reactions with IV dosing, adrenal problems (adrenal insufficiency and Cushing syndrome, including with steroids), pancreatitis, and bone changes such as fluorosis and periostitis with long-term therapy. Voriconazole can harm an unborn baby; effective contraception is advised.

Drug interactions are a big deal with voriconazole because it is handled by, and affects, the CYP2C19, CYP2C9 and CYP3A4 enzymes. It is contraindicated with pimozide, quinidine, ivabradine, sirolimus, ergot alkaloids, rifampin, carbamazepine, long-acting barbiturates, standard-dose efavirenz, high-dose ritonavir, rifabutin, St. John's wort, naloxegol, tolvaptan, lurasidone, and venetoclax at initiation and ramp-up in CLL/SLL. The tablets contain lactose and should be avoided if you have galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Give your pharmacist a full list of everything you take, including supplements. This page is general information, not medical advice; talk with your provider or pharmacist about your own situation.