Amoxicillin Trihydrate
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What is Amoxicillin Trihydrate?
Amoxicillin trihydrate is the crystalline salt form of amoxicillin — the same widely used penicillin-class antibiotic prescribed for strep throat, ear infections, sinus infections, urinary tract infections, pneumonia, skin infections, and many other common bacterial infections. The trihydrate form is the standard form found in most oral capsule, tablet, and suspension products. Amoxicillin trihydrate is chemically identical to amoxicillin in its clinical effects — it destroys bacteria by blocking cell wall synthesis. Standard adult dosing is 500–875 mg every 8–12 hours for 7–14 days depending on the type and severity of infection. A licensed provider can prescribe amoxicillin through Rx.com telehealth for appropriate bacterial infections. Generic amoxicillin is affordable — often under $10 with an Rx.com coupon.Side Effects
- Nausea
- Diarrhea
- Vomiting
Warnings
- Do not use if allergic to penicillin or cephalosporin antibiotics.
- Prolonged use may result in fungal or bacterial superinfection, including Clostridioides difficile-associated diarrhea.
- Use caution if you have renal (kidney) impairment or are taking other nephrotoxic drugs.
- May decrease the effectiveness of oral contraceptives.
Prescription savings · · · ·
What is Amoxicillin Trihydrate ?
Amoxicillin trihydrate is the crystalline salt form of amoxicillin — the same widely used penicillin-class antibiotic prescribed for strep throat, ear infections, sinus infections, urinary tract infections, pneumonia, skin infections, and many other common bacterial infections. The trihydrate form is the standard form found in most oral capsule, tablet, and suspension products. Amoxicillin trihydrate is chemically identical to amoxicillin in its clinical effects — it destroys bacteria by blocking cell wall synthesis. Standard adult dosing is 500–875 mg every 8–12 hours for 7–14 days depending on the type and severity of infection. A licensed provider can prescribe amoxicillin through Rx.com telehealth for appropriate bacterial infections. Generic amoxicillin is affordable — often under $10 with an Rx.com coupon.- Nausea
- Diarrhea
- Vomiting
- Rash
- Allergic reactions including anaphylaxis
- Do not use if allergic to penicillin or cephalosporin antibiotics.
- Prolonged use may result in fungal or bacterial superinfection, including Clostridioides difficile-associated diarrhea.
- Use caution if you have renal (kidney) impairment or are taking other nephrotoxic drugs.
- May decrease the effectiveness of oral contraceptives.
Amoxicillin Trihydrate Coupons & Prices
Amoxicillin Trihydrate 10000GM of
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Use an Rx.com amoxicillin trihydrate coupon to compare cash prices at more than 60,000 pharmacies before you fill your prescription. Amoxicillin trihydrate is the generic form of a widely used penicillin-class antibiotic, and what you pay for it can differ quite a bit from one pharmacy to the next, even between two stores on the same street. Because almost all oral amoxicillin sold in the U.S. today is generic, there is no brand coupon to chase and no manufacturer savings card for it. Enter your ZIP code above to see today's price near you, then take the free coupon to the pharmacy counter.
What is amoxicillin trihydrate and how does it work?
Amoxicillin trihydrate is an aminopenicillin, a penicillin-class beta-lactam antibiotic and a semisynthetic analog of ampicillin. It is bactericidal, meaning it kills susceptible bacteria rather than simply slowing them down, by interfering with the bacteria's ability to build a working cell wall. It is FDA-approved for infections caused by susceptible bacteria, including upper respiratory tract infections of the ear, nose and throat; lower respiratory tract infections; genitourinary tract infections; skin and skin structure infections; and, in adults, Helicobacter pylori infection and duodenal ulcer disease when combined with a proton pump inhibitor and/or clarithromycin.
Amoxicillin does not work against colds, the flu, or other viral infections. Prescribing an antibiotic when there is no proven or strongly suspected bacterial infection drives antibiotic resistance, which is why your prescriber decides whether it is the right choice. The oral amoxicillin market in the U.S. today is essentially all generic. Amoxicillin is also a component of some combination products, including Talicia, Voquezna Dual Pak and Voquezna Triple Pak.
What amoxicillin trihydrate costs without insurance
Amoxicillin trihydrate is a generic drug, so there is no manufacturer savings card and no brand program to enroll in. That does not mean every pharmacy charges the same thing. Cash prices for the same strength and quantity vary widely by pharmacy and by ZIP code, and the difference between the highest and lowest price in a single town can be larger than people expect. That is the entire reason comparing before you fill is worth the two minutes it takes.
Rx.com compares cash prices across more than 60,000 pharmacies, including major chains and independent stores. Enter your ZIP code above to see today's price near you and print, text, or show the free coupon at the counter. If you have insurance, it is still worth checking both ways: sometimes a cash coupon price beats a copay, and sometimes it does not. Ask the pharmacist for whichever is lower. A coupon is not insurance, and you cannot combine it with your insurance benefit on the same fill.
Amoxicillin trihydrate vs. related antibiotics
Which antibiotic is right depends on the infection, your allergy history, and local resistance patterns, so this is your prescriber's call rather than a menu to pick from. That said, these are drugs people commonly compare or ask about:
- Amoxicillin is the same active drug; amoxicillin trihydrate is simply the hydrated form of amoxicillin used in most oral products.
- Augmentin and its generic, amoxicillin and clavulanate potassium, add clavulanate to help amoxicillin work against certain bacteria that would otherwise break it down.
- Penicillin V potassium is another penicillin-class option with a narrower spectrum.
- Cephalexin is a cephalosporin. Note that people allergic to penicillins can sometimes react to cephalosporins as well.
- Azithromycin and doxycycline are from different classes and are often considered when a penicillin is not appropriate.
Prices for each of these vary by pharmacy too, so if your prescriber gives you a choice, it is fair to ask which options are reasonable and then compare prices for each.
Safety information you should know
Amoxicillin has no boxed warning. It is contraindicated in anyone with a history of a serious allergic reaction to any penicillin. Serious and occasionally fatal hypersensitivity and anaphylactic reactions have occurred, and cross-reactivity is possible in people allergic to cephalosporins. Get emergency help for trouble breathing, swelling of the face or throat, or a severe or spreading rash. Clostridioides difficile-associated diarrhea and pseudomembranous colitis can occur during or after treatment, so tell your provider about diarrhea that is severe or persistent. Skin reactions range from a common maculopapular rash to serious reactions including Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS, and acute generalized exanthematous pustulosis. The labeling notes that a high percentage of patients with mononucleosis who receive amoxicillin develop an erythematous skin rash, and that amoxicillin should not be given to patients with mononucleosis. Hepatic dysfunction with cholestatic jaundice and interstitial nephritis have also been reported.
According to the labeling, amoxicillin may affect the intestinal flora, leading to lower estrogen reabsorption and reduced effectiveness of combined oral estrogen/progesterone contraceptives. It also interacts with probenecid, allopurinol (increased rash), methotrexate, and warfarin (raised INR). A dose reduction is needed in severe kidney impairment. Common side effects include nausea, vomiting, diarrhea, and reversible tooth discoloration, mostly with the liquid suspension in children. Take the full course exactly as prescribed even if you feel better early. This page is general information, not medical advice. Talk with your doctor or pharmacist about your own health, allergies, and other medicines.
This Amoxicillin Trihydrate information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Amoxicillin Trihydrate on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.