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Clindamycin Hcl Capsule — prescription drug image

Clindamycin Hcl

Clindamycin HCl 300MG

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What is Clindamycin Hcl?

Cleocin is used to treat bacterial infections. The generic version of Cleocin is Clindamycin. On average Cleocin is priced at about $455 for a supply of 30, 300 mg capsules. Luckily, you can use our Rx.com savings offer to receive a Cleocin discount of up to 80% off the retail price at participating pharmacies near you.

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What is Clindamycin Hcl ?

Cleocin is used to treat bacterial infections. The generic version of Cleocin is Clindamycin. On average Cleocin is priced at about $455 for a supply of 30, 300 mg capsules. Luckily, you can use our Rx.com savings offer to receive a Cleocin discount of up to 80% off the retail price at participating pharmacies near you.

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Unusual bleeding, bruising, or weakness
  • Fever, chills, cough, sore throat, body aches
  • Severe diarrhea that does not go away, stomach cramps
  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, allergies (including an allergy to aspirin), asthma, or stomach or bowel problems (including colitis).
  • This medicine may cause severe skin reactions.
  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Unusual bleeding, bruising, or weakness
What is clindamycin HCl used to treat?

Clindamycin HCl treats serious bacterial infections caused by susceptible anaerobic bacteria and certain gram-positive organisms. These include respiratory tract, skin and soft tissue, intra-abdominal, gynecologic, and bone and joint infections, as well as bloodstream infections (septicemia). It is reserved for serious infections where less toxic antibiotics are not appropriate, and it does not work against viral illnesses like colds or the flu.

What are the most common side effects of clindamycin?

The most notable risk is diarrhea, which can occasionally become severe (Clostridioides difficile infection or pseudomembranous colitis) even weeks after treatment ends. Other reactions can include allergic responses and skin reactions. If you have watery or bloody diarrhea, severe rash, or trouble breathing, contact your provider right away. Ask your pharmacist for the full list of side effects.

Is clindamycin a penicillin or related to it?

No. Clindamycin is a lincosamide (lincomycin-class) antibiotic and is not related to penicillin. Because of this, it is sometimes used in people who are allergic to penicillin. Still, always tell your provider about all of your drug allergies before starting any antibiotic.

How long does it take for clindamycin to start working?

Many people begin to feel better within a couple of days of starting clindamycin, though this varies by the type and severity of the infection. It is important to take the full course exactly as prescribed, even if you feel better, so the infection is fully cleared and to reduce the risk of resistance. Contact your provider if you do not improve or feel worse.

What should you avoid while taking clindamycin?

Avoid taking clindamycin for nonbacterial infections such as most colds and other upper respiratory illnesses, since it will not help and adds risk. It should be avoided by people with a history of antibiotic-associated colitis. Do not treat diarrhea with over-the-counter anti-diarrhea products without checking with your provider first, and tell your provider about all other medicines you take. Follow your prescriber's and pharmacist's directions.

How much does Clindamycin HCl 300MG cost without insurance?
The price of Clindamycin HCl 300MG without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save 60–90% off retail prices with a free Rx.com coupon.
What are the common side effects of Clindamycin HCl 300MG?
Common side effects of Clindamycin HCl 300MG may include: Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Blistering, peeling, red skin rash, Unusual bleeding, bruising, or weakness, Fever, chills, cough, sore throat, body aches, Severe diarrhea that does not go away, stomach cramps. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Clindamycin HCl 300MG?
Generic versions may be available for Clindamycin HCl 300MG. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Clindamycin HCl 300MG on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Clindamycin HCl 300MG?
The cheapest pharmacy for Clindamycin HCl 300MG depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Clindamycin HCl 300MG near you.

Clindamycin Hcl Coupons & Prices

Clindamycin HCl 300MG

Skin Care
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Clindamycin Hcl Capsule — prescription drug image
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Looking for a clindamycin HCl coupon? Clindamycin hydrochloride is the generic form of Cleocin, a lincosamide antibiotic used to treat serious bacterial infections. Because it is already available as a low-cost generic, you usually do not need insurance to afford it — but the cash price can vary widely from one pharmacy to the next, sometimes dramatically for the very same prescription. Rx.com compares clindamycin HCl prices across more than 60,000 U.S. pharmacies so you can find the lowest price near you. Enter your ZIP above to see today's price and a free coupon you can bring to the pharmacy counter.

What is clindamycin HCl and how does it work?

Clindamycin hydrochloride (brand names Cleocin and Cleocin HCl) is a lincosamide, or lincomycin-class, antibiotic taken by mouth. It works by stopping bacteria from making the proteins they need to grow and multiply, which helps your body clear the infection. It is active against many anaerobic bacteria and certain gram-positive organisms.

Doctors prescribe clindamycin for serious bacterial infections such as those of the respiratory tract, skin and soft tissue, abdomen, and bones and joints, as well as certain gynecologic infections and bloodstream infections (septicemia). It is generally reserved for serious infections where less toxic antibiotics are not appropriate. Clindamycin only treats bacterial infections — it will not help colds, flu, or other viral illnesses. This page is general information, not medical advice; your provider decides whether clindamycin is right for you.

Clindamycin HCl cost and savings without insurance

Clindamycin HCl is a generic, so it is typically one of the more affordable antibiotics — but "affordable" still depends heavily on where you fill it. Two pharmacies in the same town can charge very different cash prices for an identical clindamycin prescription, which is exactly why comparing before you buy is worth it. If you are paying out of pocket or your insurance does not cover it well, a free Rx.com coupon may cost less than your copay.

To see real, current pricing, enter your ZIP above. Rx.com checks prices at more than 60,000 pharmacies and shows you today's price plus a printable or textable coupon. There is no membership fee and no insurance required — you simply show the coupon at the pharmacy. Because generics like clindamycin are inexpensive to begin with, a little comparison shopping often makes the biggest difference in what you actually pay.

Related antibiotics and alternatives

If you were prescribed the brand version, note that Cleocin and generic clindamycin HCl contain the same active ingredient; the generic is almost always the lower-cost choice. Clindamycin also comes in a topical form, clindamycin phosphate, used for skin conditions.

Depending on the infection, your provider may consider a different antibiotic. Common alternatives people compare include doxycycline, amoxicillin, metronidazole, and cephalexin. Only your prescriber can choose the right antibiotic for your specific infection — but you can compare the cash price of whichever one you are prescribed right here on Rx.com.

Important safety information

Clindamycin carries a boxed warning — the FDA's strongest — for Clostridioides difficile-associated diarrhea (CDAD). This can range from mild diarrhea to a serious, sometimes fatal condition called pseudomembranous colitis, and it can begin during treatment or even weeks after you finish the medicine. For this reason, clindamycin is reserved for serious infections and should not be used for nonbacterial illnesses such as most upper respiratory infections. If you develop watery or bloody diarrhea, contact your provider right away and do not take anti-diarrhea medicine on your own.

Clindamycin should be avoided in people with a history of antibiotic-associated colitis. Rare but severe allergic reactions (including anaphylaxis) and serious skin reactions such as DRESS and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) have also been reported. Tell your provider about any drug allergies and all other medicines you take. This is not a complete list of risks and is not medical advice — always follow your prescriber's and pharmacist's directions and read the medication guide.

Sources & accuracy

This Clindamycin Hcl information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Clindamycin Hcl on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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