Ezetimibe-Simvastatin Coupons & Prices

Looking for an ezetimibe-simvastatin coupon? Ezetimibe and simvastatin is the generic version of Vytorin, a single tablet that combines two different cholesterol-lowering medicines. Even though a generic is available, what you pay at the counter can vary a lot from one pharmacy to the next in the same town, so it is worth checking before you fill. Rx.com compares cash prices at more than 60,000 pharmacies and gives you a free coupon you can show at the register. Enter your ZIP code above to see today's price for your strength and quantity near you.

What is ezetimibe-simvastatin and how does it work?

Ezetimibe and simvastatin is a fixed-dose combination lipid-lowering tablet. It pairs two medicines that lower LDL ("bad") cholesterol in different ways. Ezetimibe is a cholesterol absorption inhibitor, which reduces the amount of cholesterol your body takes in from food. Simvastatin is an HMG-CoA reductase inhibitor, better known as a statin, which reduces the amount of cholesterol your body makes. Using both together lowers LDL more than either one alone.

It is FDA-approved as an addition to diet to reduce elevated LDL cholesterol in adults with primary hyperlipidemia; to reduce LDL cholesterol in children 10 years and older with heterozygous familial hypercholesterolemia (HeFH); and, added to other LDL-lowering therapy, in adults with homozygous familial hypercholesterolemia (HoFH). The simvastatin component is also indicated to reduce the risk of total mortality by reducing coronary heart disease death, and to reduce the risk of non-fatal heart attack, stroke, and the need for revascularization procedures, in adults with established coronary heart disease, cerebrovascular disease, peripheral vascular disease, and/or diabetes who are at high risk of coronary heart disease events. Tablets come in 10/10, 10/20, 10/40, and 10/80 mg.

What ezetimibe-simvastatin costs without insurance

There is no manufacturer savings card for generic ezetimibe-simvastatin, so if you are paying cash the main lever you have is where you fill it. Cash prices for the same strength and quantity are not standardized. Two pharmacies a few blocks apart can be quite different, and the price also moves with how many tablets you get at once, so a 90-day fill often prices out differently per tablet than a 30-day fill. Ask your prescriber whether a 90-day supply makes sense for you.

Rx.com's coupon is free and works as a cash-discount card, not insurance. You do not need to be uninsured to use it, but you cannot combine it with your insurance benefit on the same fill. Enter your ZIP above to compare today's prices near you across our 60,000+ pharmacy network, then show the coupon to the pharmacist. One more honest note: many people are prescribed the two ingredients as separate generic tablets instead of the combination, and that route sometimes prices out lower. It is worth pricing both ways before you decide.

Vytorin, the separate generics, and other options

Vytorin is the brand name for this exact combination, and an FDA-approved generic is available. Whether your pharmacy can swap the generic for a brand-name prescription depends on your state's substitution law and on what your prescriber wrote, so ask the pharmacist. You can also take the same two ingredients as separate pills: ezetimibe (brand Zetia) plus simvastatin (brand Zocor). The labeling states that the combination tablets are bioequivalent to taking the corresponding doses of ezetimibe and simvastatin as individual tablets, and clinicians commonly prescribe them separately. That is not the same as the two separate tablets being an FDA-rated substitute for the combination, so this is a prescribing decision for your doctor rather than a swap you can make at the counter.

If a statin alone is enough for your LDL goal, or if your doctor wants a different statin, other widely used generic options include atorvastatin, rosuvastatin, and pravastatin. These are not interchangeable with each other on your own. Which statin and which dose is right depends on your LDL level, your cardiovascular risk, your kidney and liver function, and your other medicines. Bring the comparison to your prescriber rather than switching yourself.

Safety, interactions, and what to avoid

Ezetimibe-simvastatin does not carry a boxed warning. The main risk is muscle injury: myopathy and, rarely, rhabdomyolysis. That risk goes up with higher simvastatin doses and is greater if you are 65 or older, female, have untreated hypothyroidism, or have kidney problems. A rare immune-mediated necrotizing myopathy has been reported and requires stopping the drug. Tell your doctor promptly about unexplained muscle pain, tenderness, or weakness. Because of that muscle risk, patients who do not reach their LDL goal on 10/40 mg should not be titrated up to 10/80 mg; the labeling restricts 10/80 mg to adults who have already been taking that strength chronically (for example, 12 months or more) without evidence of muscle toxicity, and says that patients needing more LDL lowering should be prescribed an alternative LDL-lowering treatment instead. Liver enzyme elevations can occur and rare fatal liver failure has been reported, so the labeling says to consider liver enzyme testing before you start and when clinically indicated thereafter.

It should not be used with strong CYP3A4 inhibitors such as certain azole antifungals, the antibiotics erythromycin, clarithromycin, and telithromycin, certain antivirals, or nefazodone, and not with cyclosporine, danazol, or gemfibrozil. (Not every macrolide is affected; azithromycin, for example, is not a strong CYP3A4 inhibitor.) It is also contraindicated in acute liver failure or decompensated cirrhosis, and in anyone allergic to either ingredient. Avoid grapefruit juice. Some combinations need monitoring rather than avoidance: warfarin-type blood thinners (INR checks), digoxin levels, fenofibrate (gallstone risk), and niacin at 1 gram a day or more (added muscle risk; not recommended in Chinese patients). Bile acid sequestrants should be taken 2 hours before or 4 hours after this tablet. It may harm a developing baby, so stop it if you become pregnant and tell your provider; breastfeeding is not recommended during treatment. This page is information, not medical advice. Give your provider and pharmacist your full medicine list.