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Omeprazole Magnesium

Omeprazole Magnesium 14 Tablets Delayed Release

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What is Omeprazole Magnesium?

Omeprazole Magnesium is a medication used to treat certain stomach and esophagus problems, such as acid reflux. It helps reduce the amount of acid your stomach makes, providing relief from symptoms like heartburn.

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What is Omeprazole Magnesium ?

Omeprazole Magnesium is a medication used to treat certain stomach and esophagus problems, such as acid reflux. It helps reduce the amount of acid your stomach makes, providing relief from symptoms like heartburn.

Source: MedlinePlus, U.S. National Library of Medicine

  • Blistering, peeling, red skin rash
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Unusual bleeding, bruising, tiredness, or weakness
  • Severe diarrhea that does not go away, stomach cramps or pain, nausea, vomiting, loss of appetite, weight loss
  • Fever, swelling in the body, unusual weight gain, change in how much or how often you urinate, blood in the urine
  • Dry mouth, increased thirst, confusion, numbness and tingling around the mouth, fingertips, or feet
  • Seizures, dizziness, fast or uneven heartbeat, muscle cramps or twitching
  • Joint pain, rash on your cheeks or arms that gets worse in the sun
  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, lupus, or osteoporosis.
  • This medicine may cause the following problems: Kidney problems, including acute tubulointerstitial nephritisIncreased risk of broken bones in the hip, wrist, or spine (more likely if used several times per day or longer than 1 year)Serious skin reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, and drug reaction with eosinophilia and systemic symptoms (DRESS)LupusFundic gland polyps (abnormal growth in the upper part of your stomach)
  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
What is omeprazole magnesium used for?
Over the counter (as Prilosec OTC, a 20 mg omeprazole equivalent), omeprazole magnesium treats frequent heartburn that happens 2 or more days a week in adults, taken as a 14-day course. Prescription omeprazole, including omeprazole magnesium, treats GERD, erosive esophagitis, stomach and duodenal ulcers, H. pylori infection (with antibiotics), and rare acid-oversecretion conditions like Zollinger-Ellison syndrome.
What is the difference between omeprazole and omeprazole magnesium?
They are essentially the same active drug. Omeprazole magnesium is the magnesium salt of omeprazole, a form used in certain products such as Prilosec OTC. Both lower stomach acid the same way as proton pump inhibitors; the salt form mainly affects how the medicine is formulated, not how it works in your body.
How long does it take for omeprazole magnesium to work?
It is not an instant heartburn remedy. Some people feel better within a day or so, but full effect builds over the 14-day course of Prilosec OTC. If your frequent heartburn is not controlled after completing a 14-day course, talk to your doctor rather than continuing on your own.
Can you take omeprazole magnesium every day long term?
For over-the-counter use, it is meant for a 14-day course no more than once every 4 months unless a doctor directs otherwise. Long-term daily use raises the risk of low magnesium, vitamin B12 deficiency, bone fractures, certain infections, and kidney problems, so ongoing use should be supervised by your provider.
Is Prilosec OTC the same as omeprazole magnesium?
Yes. Prilosec OTC is an over-the-counter product that delivers a 20 mg omeprazole equivalent using omeprazole magnesium. A generic omeprazole magnesium version is also available, which is often the lower-cost way to get the same medicine.
How much does Omeprazole Magnesium cost without insurance?
The price of Omeprazole Magnesium without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Omeprazole Magnesium?
Common side effects of Omeprazole Magnesium may include: Blistering, peeling, red skin rash, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Unusual bleeding, bruising, tiredness, or weakness, Severe diarrhea that does not go away, stomach cramps or pain, nausea, vomiting, loss of appetite, weight loss, Fever, swelling in the body, unusual weight gain, change in how much or how often you urinate, blood in the urine. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Omeprazole Magnesium?
Generic versions may be available for Omeprazole Magnesium. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Omeprazole Magnesium on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Omeprazole Magnesium?
The cheapest pharmacy for Omeprazole Magnesium depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Omeprazole Magnesium near you.

Omeprazole Magnesium Coupons & Prices

Omeprazole Magnesium 14 Tablets Delayed Release

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Omeprazole Magnesium Bottle — prescription drug image
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Omeprazole Magnesium 14 capsules delayed release (2)
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Compounded GLP-1 medications are not FDA-approved and are prepared by state-licensed compounding pharmacies. They are not affiliated with, endorsed by, or equivalent to any brand-name medication or manufacturer. Prescription required; eligibility is determined by a licensed provider. Prices are estimates and may vary.

Omeprazole magnesium is the magnesium salt of omeprazole, a proton pump inhibitor (PPI) that lowers stomach acid and is sold over the counter as Prilosec OTC for frequent heartburn. Even though the 20 mg over-the-counter version needs no prescription, and prescription strengths do, an omeprazole magnesium coupon from Rx.com can help you pay less at the pharmacy counter. Enter your ZIP above to see today's price near you before you buy.

What is omeprazole magnesium and how does it work?

Omeprazole magnesium is the magnesium salt form of omeprazole, a medicine in the proton pump inhibitor (PPI) class. It works by shutting down the acid-producing pumps in the lining of your stomach, which lowers the amount of acid your stomach makes. Less acid means less burning and irritation in the esophagus and stomach.

The over-the-counter product, Prilosec OTC (a 20 mg omeprazole equivalent), is made for adults with frequent heartburn that happens 2 or more days a week. It is taken as a 14-day course, not as an instant fix for a single bout of heartburn. Prescription omeprazole, including delayed-release omeprazole magnesium granules, is used for a wider range of acid-related conditions such as gastroesophageal reflux disease (GERD), erosive esophagitis, duodenal and gastric ulcers, eradicating H. pylori infection (combined with antibiotics), and rare acid-oversecretion disorders like Zollinger-Ellison syndrome.

How to save on omeprazole magnesium with an Rx.com coupon

Because Prilosec OTC is sold over the counter, you can buy it off the shelf without a prescription. But over-the-counter does not always mean cheapest: the same medicine is often available as a generic omeprazole magnesium, and in some cases the price is lower when your doctor writes a prescription and you use a discount coupon instead of paying the retail shelf price. It is worth comparing both ways.

Enter your ZIP code above to see today's price at pharmacies near you and to pull up a free Rx.com coupon. Prices vary by pharmacy and location, so it pays to check a few nearby options before you fill. There is no manufacturer copay card for this medicine, so the coupon price is what you compare against the store's over-the-counter price.

How omeprazole magnesium compares to other acid reducers

Omeprazole magnesium is one of several proton pump inhibitors, and they all lower stomach acid in a similar way, though people sometimes respond better to one than another. A generic, substitutable version of omeprazole magnesium is available, which usually keeps costs down.

Related options in the same PPI family include omeprazole (the base form, which is what Prilosec OTC delivers), esomeprazole (Nexium), pantoprazole (Protonix), and lansoprazole (Prevacid). If you have tried one PPI and it did not control your heartburn, ask your provider or pharmacist whether switching to another makes sense for you. This is general information, not medical advice.

Safety and side effects to know

Omeprazole magnesium has no boxed warning. It is generally well tolerated for short-term use, but PPI risks tend to rise with long-term or high-dose use. These can include low blood magnesium (hypomagnesemia, especially after a year or more of use), vitamin B12 deficiency, a higher chance of bone fractures of the hip, wrist, or spine, Clostridioides difficile-associated diarrhea, acute interstitial nephritis (a kidney inflammation), and lupus-like skin or body-wide reactions. For over-the-counter use, limit yourself to a 14-day course no more than once every 4 months unless your doctor tells you otherwise.

Omeprazole can also make the blood thinner clopidogrel work less well and can affect medicines whose absorption depends on stomach acid, so tell your pharmacist about everything you take. Stop and seek care for warning signs such as trouble or pain swallowing, bloody or black stools, or chest pain. When in doubt, talk with your provider before starting or continuing.

Sources & accuracy

This Omeprazole Magnesium information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Omeprazole Magnesium on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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