Omeprazole-Sodium Bicarbonate Coupons & Prices

An omeprazole-sodium bicarbonate coupon from Rx.com can lower what you pay at the pharmacy counter for this immediate-release proton pump inhibitor combination. It is not one single product: Zegerid capsules and Zegerid powder-for-oral-suspension packets are one prescription product line, and Konvomep is a separate, differently formulated prescription oral suspension with its own narrower FDA-approved uses. Cash prices for the same strength and quantity can differ a lot from one pharmacy to the next, even within the same town. Rx.com compares prices across more than 60,000 pharmacies, so enter your ZIP above to see today's price near you and bring the free coupon with you. This page is for information only and is not medical advice.

What omeprazole-sodium bicarbonate is and how it works

Omeprazole and sodium bicarbonate is a combination product. Omeprazole is a proton pump inhibitor (PPI), which reduces the amount of acid your stomach makes. The sodium bicarbonate is an antacid buffer that protects the omeprazole from stomach acid so it can be absorbed quickly. That buffer is not there to treat your heartburn on its own, and that quick-absorption design is why this product is often called an "immediate-release" PPI, unlike delayed-release omeprazole capsules.

The important thing to know is that the prescription products sold under this name are not all the same, and their FDA-approved uses are not the same either. Ask your prescriber and pharmacist which specific product you are getting.

Zegerid capsules and Zegerid for oral suspension. Each Zegerid capsule pairs 20 mg or 40 mg of omeprazole with 1,100 mg of sodium bicarbonate. Each Zegerid powder-for-oral-suspension packet pairs 20 mg or 40 mg of omeprazole with 1,680 mg of sodium bicarbonate. Per the current label, both the capsules and the oral suspension are indicated in adults for short-term treatment of active duodenal ulcer; short-term treatment (4 to 8 weeks) of active benign gastric ulcer; treatment of heartburn and other symptoms associated with GERD for up to 4 weeks; short-term treatment (4 to 8 weeks) of erosive esophagitis (EE) due to acid-mediated GERD diagnosed by endoscopy in adults; and maintenance of healing of EE due to acid-mediated GERD. One more indication belongs to the oral suspension only: reduction of risk of upper GI bleeding in critically ill adult patients. The capsules do not carry that indication.

Konvomep. Konvomep is a different formulation, not a brand name for the Zegerid packets. It is supplied as a kit that the pharmacy reconstitutes into a suspension containing 2 mg of omeprazole and 84 mg of sodium bicarbonate per mL. Its FDA-approved uses are narrower. Per its label, Konvomep is indicated in adults only for short-term treatment (4 to 8 weeks) of active benign gastric ulcer and for reduction of risk of upper GI bleeding in critically ill adult patients. It is not FDA-approved for duodenal ulcer, for heartburn or other symptoms of GERD, for treatment of erosive esophagitis, or for maintenance of healing of erosive esophagitis. Do not assume the Zegerid packet specifications or the Zegerid use list apply to Konvomep.

Separately, Zegerid OTC (20 mg/1,100 mg) is an over-the-counter product for frequent heartburn happening 2 or more days a week, taken as a 14-day course.

What it costs without insurance, and why comparing pharmacies matters

Generic availability depends on which form you are filling. Generic omeprazole and sodium bicarbonate is marketed in both the capsule and the powder-for-oral-suspension forms that correspond to Zegerid. Konvomep is a different story: as of this writing there is no FDA-approved generic of Konvomep, so it is a brand-only product. Whether your pharmacy can hand you a generic in place of a brand depends on the product's therapeutic-equivalence rating and on your state's substitution law, so ask your pharmacist what they are able to dispense against your specific prescription.

Manufacturer assistance also differs by product. Azurity, which markets Konvomep, runs a co-pay savings program for Konvomep; its own materials describe it as applied automatically at the pharmacy for eligible commercially insured patients, and it excludes prescriptions paid in whole or in part by federal or state programs such as Medicare, Medicaid, TRICARE, or the VA. Program terms and eligibility change, so check the manufacturer's current program page or ask your pharmacist rather than relying on this page.

If you are paying cash, the number that matters is the one at the specific pharmacy you walk into, and those cash prices vary widely: the same strength and quantity can be priced very differently at a chain store, a grocery pharmacy, and an independent down the street. That is exactly why comparing is worth the two minutes. Enter your ZIP above to see today's price at pharmacies near you and print, text, or show the free Rx.com coupon at the counter. A few things that change your price: capsules versus suspension, the 20 mg versus 40 mg strength, brand versus generic, and the quantity your prescriber writes. Ask your pharmacist to run the coupon price and your insurance price separately, then use whichever is lower. If your provider is treating occasional heartburn rather than a diagnosed ulcer or erosive esophagitis, ask whether an over-the-counter option would do the same job for less.

How it compares to regular omeprazole and other acid reducers

The most important comparison is with plain omeprazole delayed-release capsules. They contain the same active drug, but they are not interchangeable milligram-for-milligram, because the bicarbonate-buffered product is absorbed differently. Within the buffered capsules, two 20 mg capsules are not equivalent to one 40 mg capsule, since each capsule carries its own full 1,100 mg of sodium bicarbonate. Never swap between any of these products on your own; that is a prescriber's call.

Other proton pump inhibitors your prescriber may consider include esomeprazole, pantoprazole, lansoprazole, dexlansoprazole, and rabeprazole. Famotidine works by a different mechanism (an H2 blocker) and is sometimes used instead. One practical reason a prescriber picks a suspension form rather than a capsule is that the labeling for these suspensions includes administration through a nasogastric or orogastric tube, where a capsule is impractical. Which one is right for you depends on your diagnosis, your other medicines, and your kidney, heart, and blood pressure history, so talk it through with your provider before switching.

Safety, sodium content, and interactions to know

These products do not carry a boxed warning. They are contraindicated in anyone with known hypersensitivity to substituted benzimidazoles or to any component of the formulation; anaphylaxis, angioedema, bronchospasm, interstitial nephritis, and urticaria have been reported. Proton pump inhibitors are also contraindicated in patients taking rilpivirine-containing products.

The sodium load deserves attention, and it is not the same across forms. Per the Zegerid label, each capsule contains 1,100 mg (13 mEq) of sodium bicarbonate and a total of 304 mg of sodium, and each powder-for-oral-suspension packet contains 1,680 mg (20 mEq) of sodium bicarbonate and a total of 460 mg of sodium. Konvomep carries more: its label states that the total sodium content per 40 mg dose (a volume of 20 mL) is 526 mg (22.8 mEq). Use caution if you are on a sodium-restricted diet or have heart failure, high blood pressure, or kidney disease, and also with metabolic alkalosis or low calcium. Tell your provider about all of these before starting, and make sure they know which specific product you are on.

Other label warnings include: feeling better does not rule out stomach cancer; acute interstitial nephritis (a kidney reaction) can happen at any point in therapy; vitamin B-12 deficiency with use beyond about 3 years; low magnesium with use typically beyond a year, which can affect the heart and nerves; a higher risk of osteoporosis-related hip, wrist, and spine fractures with long-term multiple-daily-dose therapy; a higher risk of Clostridioides difficile diarrhea; cutaneous and systemic lupus erythematosus; and fundic gland polyps with long-term use. Avoid taking it with clopidogrel, since omeprazole blocks CYP2C19 and reduces clopidogrel's antiplatelet effect. It can also reduce absorption of drugs that need stomach acid (atazanavir, nelfinavir, ketoconazole, itraconazole, erlotinib, mycophenolate) and raise levels of methotrexate, tacrolimus, diazepam, cilostazol, and warfarin (your INR should be monitored). The general guidance on the label is the lowest effective dose for the shortest time. Bring your full medication list to your prescriber or pharmacist; this page is not medical advice.